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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MAP7

Summary for MAP7

Gene information	Gene symbol	MAP7
	Ensembl ID	ENSG00000135525
	Entrez ID	9053
	Gene name	microtubule associated protein 7
	Synonyms	E-MAP-115
	Gene type	protein_coding
	UniProtAcc	Q14244

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Dataset with differentially expressed gene: MAP7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.613035	0.00e+00

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Expression of MAP7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAP7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAP7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAP7	hsa-miR-3194-5p	85.0228	NM_001198614
MAP7	hsa-miR-186-5p	84.5362	NM_001198608
MAP7	hsa-miR-659-3p	84.279	NM_001198614
MAP7	hsa-miR-6758-3p	83.7855	NM_001198614
MAP7	hsa-miR-511-5p	83.7552	NM_001198614
MAP7	hsa-miR-20a-5p	83.6184	NM_001198608
MAP7	hsa-miR-106a-5p	83.6184	NM_001198608
MAP7	hsa-miR-106b-5p	83.6184	NM_001198608
MAP7	hsa-miR-519d-3p	83.6184	NM_001198608
MAP7	hsa-miR-93-5p	83.6184	NM_001198608
MAP7	hsa-miR-20b-5p	83.6184	NM_001198608
MAP7	hsa-miR-17-5p	83.6184	NM_001198608
MAP7	hsa-miR-9-5p	82.4089	NM_001198608
MAP7	hsa-miR-548aj-5p	82.2169	NM_001198608
MAP7	hsa-miR-548x-5p	82.2169	NM_001198608
MAP7	hsa-miR-548g-5p	82.2169	NM_001198608
MAP7	hsa-miR-5691	81.6778	NM_001198608
MAP7	hsa-miR-6805-3p	81.6778	NM_001198608
MAP7	hsa-miR-15a-5p	81.6389	NM_001198608
MAP7	hsa-miR-15b-5p	81.6389	NM_001198608
MAP7	hsa-miR-16-5p	81.6389	NM_001198608
MAP7	hsa-miR-6838-5p	81.6389	NM_001198608
MAP7	hsa-miR-195-5p	81.6389	NM_001198608
MAP7	hsa-miR-4682	81.4109	NM_001198614
MAP7	hsa-miR-578	81.0446	NM_001198614
MAP7	hsa-miR-3606-3p	80.7716	NM_001198608
MAP7	hsa-miR-8067	80.7511	NM_001198608
MAP7	hsa-miR-4680-5p	80.3579	NM_001198614

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Motifs and transcription factors (TFs) regulating MAP7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAP7	metacluster_135.11	NR2C2 (directAnnotation).
MAP7	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
MAP7	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MAP7	metacluster_7.13	ZFX (directAnnotation).
MAP7	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
MAP7	cisbp__M00968	MTF2 (directAnnotation).
MAP7	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
MAP7	metacluster_160.20	JUND; PRDM15 (directAnnotation).
MAP7	cisbp__M00341	PAX6 (directAnnotation).
MAP7	metacluster_198.3	ZFP64 (directAnnotation).
MAP7	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MAP7	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
MAP7	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
MAP7	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
MAP7	cisbp__M00788	ZFY (inferredBy_Orthology).
MAP7	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
MAP7	metacluster_175.1	ZNF283 (directAnnotation).
MAP7	hdpi__ZNF304	ZNF304 (directAnnotation).
MAP7	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
MAP7	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
MAP7	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
MAP7	transfac_pro__M01199	TRIM28 (directAnnotation).
MAP7	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
MAP7	metacluster_151.2	ZNF23 (directAnnotation).
MAP7	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MAP7	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MAP7	transfac_pro__M03806	ZBTB7C (directAnnotation).
MAP7	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."