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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MAP3K20

Summary for MAP3K20

Gene information	Gene symbol	MAP3K20
	Ensembl ID	ENSG00000091436
	Entrez ID	51776
	Gene name	mitogen-activated protein kinase kinase kinase 20
	Synonyms	MLK7\|MLTK\|MLTKalpha\|MLTKbeta\|MRK\|ZAK
	Gene type	protein_coding
	UniProtAcc	Q9NYL2

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Dataset with differentially expressed gene: MAP3K20

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.273611	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.335669	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.318174	6.90e-21

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Expression of MAP3K20 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAP3K20

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAP3K20

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAP3K20	hsa-miR-92a-3p	87.73	NM_133646
MAP3K20	hsa-miR-548c-3p	87.1992	NM_133646
MAP3K20	hsa-miR-6885-3p	86.9942	NM_133646
MAP3K20	hsa-miR-892c-3p	86.927	NM_133646
MAP3K20	hsa-miR-4676-3p	86.927	NM_133646
MAP3K20	hsa-miR-452-5p	86.903	NM_133646
MAP3K20	hsa-miR-4295	86.802	NM_133646
MAP3K20	hsa-miR-23a-3p	86.5374	NM_133646
MAP3K20	hsa-miR-23b-3p	86.5374	NM_133646
MAP3K20	hsa-miR-23c	86.5374	NM_133646
MAP3K20	hsa-miR-1290	86.5089	NM_133646
MAP3K20	hsa-miR-12132	86.46	NM_016653
MAP3K20	hsa-miR-25-3p	86.3704	NM_133646
MAP3K20	hsa-miR-363-3p	86.3704	NM_133646
MAP3K20	hsa-miR-367-3p	86.3704	NM_133646
MAP3K20	hsa-miR-3145-3p	86.0477	NM_016653
MAP3K20	hsa-miR-593-3p	86.0218	NM_133646
MAP3K20	hsa-miR-548az-5p	85.8672	NM_133646
MAP3K20	hsa-miR-548t-5p	85.8672	NM_133646
MAP3K20	hsa-miR-4678	85.6974	NM_133646
MAP3K20	hsa-miR-3163	85.6146	NM_133646
MAP3K20	hsa-miR-4309	85.4353	NM_133646
MAP3K20	hsa-miR-664a-3p	85.1522	NM_133646
MAP3K20	hsa-miR-3666	85.0424	NM_133646
MAP3K20	hsa-miR-454-3p	85.0424	NM_133646
MAP3K20	hsa-miR-301b-3p	85.0424	NM_133646
MAP3K20	hsa-miR-301a-3p	85.0424	NM_133646
MAP3K20	hsa-miR-4451	84.9694	NM_133646
MAP3K20	hsa-miR-550b-3p	84.9058	NM_133646
MAP3K20	hsa-miR-3059-5p	84.7891	NM_016653
MAP3K20	hsa-miR-6733-3p	84.61	NM_133646
MAP3K20	hsa-miR-653-3p	84.5033	NM_133646
MAP3K20	hsa-miR-9851-3p	84.4503	NM_133646
MAP3K20	hsa-miR-651-3p	84.4448	NM_016653
MAP3K20	hsa-miR-4302	84.4354	NM_133646
MAP3K20	hsa-miR-593-5p	84.229	NM_133646
MAP3K20	hsa-miR-20a-5p	84.0457	NM_133646
MAP3K20	hsa-miR-106b-5p	84.0457	NM_133646
MAP3K20	hsa-miR-143-5p	83.8675	NM_133646
MAP3K20	hsa-miR-6857-3p	83.6636	NM_133646
MAP3K20	hsa-miR-3198	83.6553	NM_133646
MAP3K20	hsa-miR-4775	83.6381	NM_133646
MAP3K20	hsa-miR-3130-3p	83.4645	NM_133646
MAP3K20	hsa-miR-3920	83.2415	NM_133646
MAP3K20	hsa-miR-5087	83.1059	NM_016653
MAP3K20	hsa-miR-1289	82.6084	NM_133646
MAP3K20	hsa-miR-513b-5p	82.4885	NM_016653
MAP3K20	hsa-miR-12124	82.3716	NM_133646
MAP3K20	hsa-miR-6839-5p	82.358	NM_133646
MAP3K20	hsa-miR-331-5p	82.2668	NM_133646

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Motifs and transcription factors (TFs) regulating MAP3K20

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."