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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MAP1B

Summary for MAP1B

Gene information	Gene symbol	MAP1B
	Ensembl ID	ENSG00000131711
	Entrez ID	4131
	Gene name	microtubule associated protein 1B
	Synonyms	MAP5\|PPP1R102
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MAP1B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.355472	1.02e-21
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.819378	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.724582	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.638027	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.328579	2.68e-14
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.268335	1.19e-05
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.302492	2.59e-15
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.489567	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.315476	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.899683	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.54081	0.00e+00

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Expression of MAP1B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAP1B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAP1B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAP1B	hsa-miR-4291	91.9895	NM_005909
MAP1B	hsa-miR-4310	91.6952	NM_001324255
MAP1B	hsa-miR-6124	91.2061	NM_001324255
MAP1B	hsa-miR-4752	90.7617	NM_001324255
MAP1B	hsa-miR-7152-5p	90.7185	NM_001324255
MAP1B	hsa-miR-4290	90.572	NM_001324255
MAP1B	hsa-miR-1205	90.4858	NM_001324255
MAP1B	hsa-miR-10394-5p	90.4858	NM_001324255
MAP1B	hsa-miR-4763-3p	89.9429	NM_001324255
MAP1B	hsa-miR-1299	89.7471	NM_005909
MAP1B	hsa-miR-12122	89.3455	NM_001324255
MAP1B	hsa-miR-4760-3p	89.2636	NM_001324255
MAP1B	hsa-miR-589-3p	89.2075	NM_005909
MAP1B	hsa-miR-6835-3p	88.4144	NM_001324255
MAP1B	hsa-miR-6750-3p	88.3697	NM_001324255
MAP1B	hsa-miR-4659b-3p	88.0847	NM_001324255
MAP1B	hsa-miR-4659a-3p	88.0847	NM_001324255
MAP1B	hsa-miR-4768-5p	87.9817	NM_001324255
MAP1B	hsa-miR-590-3p	87.4458	NM_005909
MAP1B	hsa-miR-3671	87.336	NM_001324255
MAP1B	hsa-miR-5692a	87.1958	NM_001324255
MAP1B	hsa-miR-7157-5p	87.1558	NM_001324255
MAP1B	hsa-miR-1284	86.6856	NM_005909
MAP1B	hsa-miR-7150	86.5938	NM_001324255
MAP1B	hsa-miR-3617-5p	86.0231	NM_001324255
MAP1B	hsa-miR-641	86.0231	NM_001324255
MAP1B	hsa-miR-4719	86.0195	NM_005909
MAP1B	hsa-miR-96-5p	85.6123	NM_001324255
MAP1B	hsa-miR-1468-3p	85.5008	NM_001324255
MAP1B	hsa-miR-30e-3p	84.9215	NM_005909
MAP1B	hsa-miR-30d-3p	84.9215	NM_005909
MAP1B	hsa-miR-30a-3p	84.9215	NM_005909
MAP1B	hsa-miR-31-5p	84.7969	NM_005909
MAP1B	hsa-miR-3158-5p	84.5267	NM_001324255
MAP1B	hsa-miR-181b-3p	84.5088	NM_001324255
MAP1B	hsa-miR-4420	84.5088	NM_001324255
MAP1B	hsa-miR-181b-2-3p	84.5088	NM_001324255
MAP1B	hsa-miR-570-3p	83.3123	NM_005909
MAP1B	hsa-miR-664b-3p	83.2489	NM_001324255
MAP1B	hsa-miR-579-3p	83.2489	NM_001324255
MAP1B	hsa-miR-4252	82.7529	NM_001324255
MAP1B	hsa-miR-4262	82.4776	NM_001324255
MAP1B	hsa-miR-376c-3p	82.4424	NM_005909
MAP1B	hsa-miR-6856-5p	82.0283	NM_001324255
MAP1B	hsa-miR-6758-5p	82.0283	NM_001324255
MAP1B	hsa-miR-3190-3p	81.9709	NM_001324255
MAP1B	hsa-miR-8064	81.9137	NM_001324255
MAP1B	hsa-miR-652-5p	81.7337	NM_001324255
MAP1B	hsa-miR-9-5p	81.7291	NM_001324255
MAP1B	hsa-miR-4494	81.4817	NM_005909

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Motifs and transcription factors (TFs) regulating MAP1B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAP1B	cisbp__M01863	ZNF711 (inferredBy_Orthology).
MAP1B	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
MAP1B	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
MAP1B	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MAP1B	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
MAP1B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
MAP1B	jaspar__MA0079.5	SP1 (directAnnotation).
MAP1B	transfac_pro__M03813	POU3F3 (directAnnotation).
MAP1B	hocomoco__MNX1_HUMAN.H11MO.0.D	MNX1 (directAnnotation).
MAP1B	hdpi__FOXM1	FOXM1 (directAnnotation).
MAP1B	transfac_pro__M05768	ZNF544 (directAnnotation).
MAP1B	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
MAP1B	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
MAP1B	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MAP1B	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
MAP1B	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
MAP1B	transfac_pro__M04866	HDAC2 (directAnnotation).
MAP1B	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
MAP1B	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
MAP1B	metacluster_22.13	MAFK (inferredBy_Orthology).
MAP1B	transfac_pro__M05597	ZNF174 (directAnnotation).
MAP1B	metacluster_22.11	NFE2 (directAnnotation).
MAP1B	metacluster_31.3	ZSCAN20; ZSCAN29 (directAnnotation).
MAP1B	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
MAP1B	transfac_pro__M01245	MTERF1 (directAnnotation).
MAP1B	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
MAP1B	transfac_pro__M06605	ZNF681 (directAnnotation).
MAP1B	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
MAP1B	metacluster_22.36	BACH2 (directAnnotation).
MAP1B	metacluster_22.17	NFE2 (directAnnotation).
MAP1B	kznf__ZNF90_Imbeault2017_RP_RCADE	ZNF90 (directAnnotation).
MAP1B	tfdimers__MD00074	SOX4; YY2 (directAnnotation).
MAP1B	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
MAP1B	transfac_pro__M05395	ZNF276 (inferredBy_Orthology).
MAP1B	transfac_public__M00491	PATZ1 (directAnnotation).
MAP1B	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
MAP1B	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
MAP1B	transfac_pro__M04918	EGR1 (directAnnotation).
MAP1B	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
MAP1B	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
MAP1B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MAP1B	cisbp__M00249	WT1 (directAnnotation).
MAP1B	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
MAP1B	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
MAP1B	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
MAP1B	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
MAP1B	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
MAP1B	jaspar__MA1708.1	ETV7 (directAnnotation).
MAP1B	metacluster_183.4	ETS1 (inferredBy_Orthology).
MAP1B	metacluster_81.7	CREB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."