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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: MAN2A1

Summary for MAN2A1

Gene information	Gene symbol	MAN2A1
	Ensembl ID	ENSG00000112893
	Entrez ID	4124
	Gene name	mannosidase alpha class 2A member 1
	Synonyms	GOLIM7\|MANA2
	Gene type	protein_coding
	UniProtAcc	Q16706

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Dataset with differentially expressed gene: MAN2A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.457476	8.69e-44

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Expression of MAN2A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAN2A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAN2A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAN2A1	hsa-miR-590-3p	84.2268	NM_002372
MAN2A1	hsa-miR-6788-5p	83.1389	NM_002372
MAN2A1	hsa-miR-3910	82.7037	NM_002372
MAN2A1	hsa-miR-33a-3p	82.4061	NM_002372
MAN2A1	hsa-miR-6875-3p	82.3615	NM_002372
MAN2A1	hsa-miR-4659b-3p	81.9111	NM_002372
MAN2A1	hsa-miR-4659a-3p	81.9111	NM_002372
MAN2A1	hsa-miR-6504-3p	81.8821	NM_002372
MAN2A1	hsa-miR-10399-5p	81.8821	NM_002372
MAN2A1	hsa-miR-106a-3p	81.1794	NM_002372
MAN2A1	hsa-miR-4476	81.1424	NM_002372
MAN2A1	hsa-miR-6876-5p	81.1424	NM_002372
MAN2A1	hsa-miR-3938	81.0888	NM_002372
MAN2A1	hsa-miR-548as-3p	80.9271	NM_002372
MAN2A1	hsa-miR-3714	80.7949	NM_002372
MAN2A1	hsa-miR-6878-5p	80.4163	NM_002372

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Motifs and transcription factors (TFs) regulating MAN2A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAN2A1	metacluster_135.11	NR2C2 (directAnnotation).
MAN2A1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
MAN2A1	tfdimers__MD00038	TFAP2C (directAnnotation).
MAN2A1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MAN2A1	metacluster_7.13	ZFX (directAnnotation).
MAN2A1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
MAN2A1	cisbp__M00968	MTF2 (directAnnotation).
MAN2A1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
MAN2A1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
MAN2A1	metacluster_198.3	ZFP64 (directAnnotation).
MAN2A1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MAN2A1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
MAN2A1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
MAN2A1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
MAN2A1	cisbp__M00788	ZFY (inferredBy_Orthology).
MAN2A1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
MAN2A1	metacluster_175.1	ZNF283 (directAnnotation).
MAN2A1	hdpi__ZNF304	ZNF304 (directAnnotation).
MAN2A1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
MAN2A1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
MAN2A1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
MAN2A1	transfac_pro__M01199	TRIM28 (directAnnotation).
MAN2A1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
MAN2A1	metacluster_151.2	ZNF23 (directAnnotation).
MAN2A1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MAN2A1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MAN2A1	transfac_pro__M03806	ZBTB7C (directAnnotation).
MAN2A1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MAN2A1	"(1R,2R,3R,4S,5R)-4-(Benzylamino)-5-(methylthio)cyclopentane-1,2,3-triol"	DB06984	small molecule
MAN2A1	"(1S,2S,3R,6R)-4-(hydroxymethyl)-6-(octylamino)cyclohex-4-ene-1,2,3-triol"	DB08321	small molecule
MAN2A1	"1-deoxymannojirimycin"	DB03955	small molecule
MAN2A1	"2-deoxy-2-fluoro-alpha-D-mannosyl fluoride"	DB02318	small molecule
MAN2A1	"5-fluoro-beta-L-gulosyl fluoride"	DB03008	small molecule
MAN2A1	"5-Thio-a/B-D-Mannopyranosylamine"	DB03414	small molecule
MAN2A1	"Ghavamiol"	DB02492	small molecule
MAN2A1	"Kifunensine"	DB02742	small molecule
MAN2A1	"Tridolgosir"	DB02034	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."