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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MAN1A1

Summary for MAN1A1

Gene information	Gene symbol	MAN1A1
	Ensembl ID	ENSG00000111885
	Entrez ID	4121
	Gene name	mannosidase alpha class 1A member 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P33908

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Dataset with differentially expressed gene: MAN1A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.29482	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.319007	0.00e+00

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Expression of MAN1A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAN1A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAN1A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAN1A1	hsa-miR-372-3p	84.0262	NM_005907
MAN1A1	hsa-miR-520a-3p	84.0262	NM_005907
MAN1A1	hsa-miR-373-3p	84.0262	NM_005907
MAN1A1	hsa-miR-520d-3p	84.0262	NM_005907
MAN1A1	hsa-miR-520e-3p	84.0262	NM_005907
MAN1A1	hsa-miR-520c-3p	84.0262	NM_005907
MAN1A1	hsa-miR-520b-3p	84.0262	NM_005907
MAN1A1	hsa-miR-126-5p	83.399	NM_005907
MAN1A1	hsa-miR-4775	83.3361	NM_005907
MAN1A1	hsa-let-7f-1-3p	83.0013	NM_005907
MAN1A1	hsa-miR-4477a	82.7319	NM_005907
MAN1A1	hsa-miR-551b-5p	82.672	NM_005907
MAN1A1	hsa-miR-3201	82.4829	NM_005907
MAN1A1	hsa-miR-1270	82.4169	NM_005907
MAN1A1	hsa-miR-6888-5p	81.1791	NM_005907
MAN1A1	hsa-let-7a-3p	81.1311	NM_005907
MAN1A1	hsa-miR-98-3p	81.1311	NM_005907
MAN1A1	hsa-miR-4795-3p	81.0201	NM_005907
MAN1A1	hsa-miR-6773-3p	80.2121	NM_005907
MAN1A1	hsa-miR-3913-5p	80.1616	NM_005907

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Motifs and transcription factors (TFs) regulating MAN1A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAN1A1	kznf__ZNF273_Imbeault2017_RP_RCADE	ZNF273 (directAnnotation).
MAN1A1	transfac_pro__M01973	PLAG1 (directAnnotation).
MAN1A1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP	ELK1; TBX21 (directAnnotation).
MAN1A1	transfac_public__M00051	NFKB1 (directAnnotation).
MAN1A1	jaspar__MA1522.1	MAZ (directAnnotation).
MAN1A1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
MAN1A1	transfac_pro__M06881	ZNF549 (directAnnotation).
MAN1A1	metacluster_143.13	ZBTB7A (directAnnotation).
MAN1A1	hdpi__PAXIP1	PAXIP1 (directAnnotation).
MAN1A1	transfac_pro__M05845	ZSCAN29 (directAnnotation).
MAN1A1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
MAN1A1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
MAN1A1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
MAN1A1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
MAN1A1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
MAN1A1	metacluster_55.5	ZNF541 (directAnnotation).
MAN1A1	transfac_pro__M04950	EGR1 (directAnnotation).
MAN1A1	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
MAN1A1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."