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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LSM14A

Summary for LSM14A

Gene information	Gene symbol	LSM14A
	Ensembl ID	ENSG00000262860
	Entrez ID	26065
	Gene name	LSM14A mRNA processing body assembly factor
	Synonyms	C19orf13\|DKFZP434D1335\|FAM61A\|RAP55\|RAP55A
	Gene type	protein_coding
	UniProtAcc	Q8ND56

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Dataset with differentially expressed gene: LSM14A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-1.26713	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.454278	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.28152	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.269869	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.319178	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.422547	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.32636	2.15e-41
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.567123	3.72e-03
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.342015	0.00e+00

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Expression of LSM14A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LSM14A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LSM14A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LSM14A	hsa-miR-8063	82.9726	NM_015578
LSM14A	hsa-miR-4504	82.8805	NM_001114093
LSM14A	hsa-miR-182-5p	82.7948	NM_001114093
LSM14A	hsa-miR-2276-3p	82.6628	NM_015578
LSM14A	hsa-miR-4328	82.6145	NM_001114093
LSM14A	hsa-miR-1825	81.7086	NM_001114093
LSM14A	hsa-miR-124-5p	81.0419	NM_015578
LSM14A	hsa-miR-6847-3p	80.6987	NM_015578
LSM14A	hsa-miR-203a-3p	80.5901	NM_001114093
LSM14A	hsa-miR-3116	80.1339	NM_015578
LSM14A	hsa-miR-187-5p	80.0969	NM_015578

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Motifs and transcription factors (TFs) regulating LSM14A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LSM14A	metacluster_7.13	ZFX (directAnnotation).
LSM14A	cisbp__M01863	ZNF711 (inferredBy_Orthology).
LSM14A	metacluster_151.2	ZNF23 (directAnnotation).
LSM14A	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
LSM14A	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
LSM14A	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
LSM14A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
LSM14A	metacluster_182.10	ZFX (directAnnotation).
LSM14A	hdpi__ETV4	ETV4 (directAnnotation).
LSM14A	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
LSM14A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
LSM14A	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
LSM14A	jaspar__MA0079.5	SP1 (directAnnotation).
LSM14A	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
LSM14A	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
LSM14A	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
LSM14A	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
LSM14A	jaspar__MA1122.1	TFDP1 (directAnnotation).
LSM14A	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
LSM14A	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
LSM14A	hdpi__FLI1	FLI1 (directAnnotation).
LSM14A	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
LSM14A	cisbp__M02645	ETS1 (directAnnotation).
LSM14A	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
LSM14A	transfac_pro__M06331	ZNF343 (directAnnotation).
LSM14A	hdpi__TP73	TP73 (directAnnotation).
LSM14A	transfac_pro__M04826	EP300 (directAnnotation).
LSM14A	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
LSM14A	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
LSM14A	transfac_pro__M04862	NRF1 (directAnnotation).
LSM14A	jaspar__MA0748.2	YY2 (directAnnotation).
LSM14A	transfac_pro__M01298	MECP2 (directAnnotation).
LSM14A	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
LSM14A	transfac_pro__M00492	STAT1 (directAnnotation).
LSM14A	cisbp__M00788	ZFY (inferredBy_Orthology).
LSM14A	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
LSM14A	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
LSM14A	hdpi__TIMELESS	TIMELESS (directAnnotation).
LSM14A	metacluster_191.5	SPDEF (inferredBy_Orthology).
LSM14A	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
LSM14A	transfac_pro__M02913	SP140 (inferredBy_Orthology).
LSM14A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
LSM14A	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
LSM14A	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
LSM14A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
LSM14A	transfac_pro__M01199	TRIM28 (directAnnotation).
LSM14A	hdpi__ELF2	ELF2 (directAnnotation).
LSM14A	tfdimers__MD00038	TFAP2C (directAnnotation).
LSM14A	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
LSM14A	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."