Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LRP8

Summary for LRP8

Gene information	Gene symbol	LRP8
	Ensembl ID	ENSG00000157193
	Entrez ID	7804
	Gene name	LDL receptor related protein 8
	Synonyms	APOER2\|HSZ75190\|LRP-8\|MCI1
	Gene type	protein_coding
	UniProtAcc	Q14114

Top

Dataset with differentially expressed gene: LRP8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.384653	0.00e+00

Top

Expression of LRP8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to LRP8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating LRP8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LRP8	hsa-miR-302a-3p	87.0124	NM_001018054
LRP8	hsa-miR-373-3p	87.0124	NM_001018054
LRP8	hsa-miR-302d-3p	87.0124	NM_001018054
LRP8	hsa-miR-302b-3p	87.0124	NM_001018054
LRP8	hsa-miR-520b-3p	87.0124	NM_001018054
LRP8	hsa-miR-520c-3p	87.0124	NM_001018054
LRP8	hsa-miR-302c-3p	87.0124	NM_001018054
LRP8	hsa-miR-520d-3p	87.0124	NM_001018054
LRP8	hsa-miR-520e-3p	87.0124	NM_001018054
LRP8	hsa-miR-146a-3p	86.034	NM_004631
LRP8	hsa-miR-520f-3p	85.9922	NM_001018054
LRP8	hsa-miR-3182	85.9789	NM_004631
LRP8	hsa-miR-520f-5p	85.7447	NM_004631
LRP8	hsa-miR-3163	85.4251	NM_001018054
LRP8	hsa-miR-330-3p	85.0568	NM_001018054
LRP8	hsa-miR-4729	84.8016	NM_004631
LRP8	hsa-miR-216b-5p	84.7651	NM_004631
LRP8	hsa-miR-8067	84.603	NM_001018054
LRP8	hsa-miR-6798-3p	84.5037	NM_004631
LRP8	hsa-miR-4671-3p	84.2825	NM_001018054
LRP8	hsa-miR-6870-5p	84.0362	NM_004631
LRP8	hsa-miR-7111-5p	84.0362	NM_004631
LRP8	hsa-miR-5698	84.0362	NM_004631
LRP8	hsa-miR-4723-5p	84.0362	NM_004631
LRP8	hsa-miR-6884-5p	83.0958	NM_004631
LRP8	hsa-miR-485-5p	83.0958	NM_004631
LRP8	hsa-miR-30d-3p	82.9302	NM_001018054
LRP8	hsa-miR-30a-3p	82.9302	NM_001018054
LRP8	hsa-miR-30e-3p	82.9302	NM_001018054
LRP8	hsa-miR-1322	82.5991	NM_004631
LRP8	hsa-miR-654-3p	82.5133	NM_004631
LRP8	hsa-miR-191-5p	82.377	NM_004631
LRP8	hsa-miR-1827	82.3305	NM_001018054
LRP8	hsa-miR-520d-5p	81.885	NM_001018054
LRP8	hsa-miR-524-5p	81.885	NM_001018054
LRP8	hsa-miR-4714-5p	81.8278	NM_004631
LRP8	hsa-miR-29b-2-5p	81.5075	NM_001018054
LRP8	hsa-miR-659-3p	81.2554	NM_001018054
LRP8	hsa-miR-409-5p	81.2257	NM_004631
LRP8	hsa-miR-517-5p	81.1824	NM_004631
LRP8	hsa-miR-1272	81.0649	NM_004631
LRP8	hsa-miR-6809-3p	81.0404	NM_004631
LRP8	hsa-miR-548x-5p	80.4303	NM_001018054
LRP8	hsa-miR-548aj-5p	80.4303	NM_001018054
LRP8	hsa-miR-548f-5p	80.4303	NM_001018054
LRP8	hsa-miR-548g-5p	80.4303	NM_001018054
LRP8	hsa-miR-4468	80.4058	NM_004631
LRP8	hsa-miR-3199	80.0553	NM_004631
LRP8	hsa-miR-8052	80.0553	NM_004631

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating LRP8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LRP8	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
LRP8	transfac_pro__M06071	ZNF814 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."