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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LPP

Summary for LPP

Gene information	Gene symbol	LPP
	Ensembl ID	ENSG00000145012
	Entrez ID	4026
	Gene name	LIM domain containing preferred translocation partner in lipoma
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: LPP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.270361	4.67e-29
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.69592	7.99e-19
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.366887	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.439297	3.66e-17
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.431583	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.518502	0.00e+00

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Expression of LPP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LPP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LPP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LPP	hsa-miR-5582-5p	94.0573	NM_001167671
LPP	hsa-miR-1323	93.7699	NM_001167671
LPP	hsa-miR-30e-5p	93.7531	NM_001167671
LPP	hsa-miR-30b-5p	93.7531	NM_001167671
LPP	hsa-miR-30a-5p	93.7531	NM_001167671
LPP	hsa-miR-30d-5p	93.7531	NM_001167671
LPP	hsa-miR-30c-5p	93.7531	NM_001167671
LPP	hsa-miR-548o-3p	93.3586	NM_001167671
LPP	hsa-miR-5700	93.3155	NM_001167671
LPP	hsa-miR-4722-5p	93.2279	NM_001167671
LPP	hsa-miR-548ag	93.1634	NM_001167671
LPP	hsa-miR-6740-3p	92.9937	NM_001167671
LPP	hsa-miR-6895-3p	92.9478	NM_001167671
LPP	hsa-miR-6833-3p	92.7925	NM_001167671
LPP	hsa-miR-3121-3p	92.7309	NM_001167671
LPP	hsa-miR-7114-5p	92.6984	NM_001167671
LPP	hsa-miR-3613-3p	92.6025	NM_001167671
LPP	hsa-miR-548aj-3p	92.5893	NM_001167671
LPP	hsa-miR-548x-3p	92.5893	NM_001167671
LPP	hsa-miR-6833-5p	92.4599	NM_001167671
LPP	hsa-miR-876-5p	92.4318	NM_001167671
LPP	hsa-miR-6507-5p	92.3926	NM_001167671
LPP	hsa-miR-548at-5p	92.0782	NM_001167671
LPP	hsa-miR-3924	92.0288	NM_001167671
LPP	hsa-miR-7162-3p	91.8829	NM_001167671
LPP	hsa-miR-3167	91.8217	NM_001167671
LPP	hsa-miR-3185	91.5993	NM_001167671
LPP	hsa-miR-548aq-3p	91.303	NM_001167671
LPP	hsa-miR-548ae-3p	91.303	NM_001167671
LPP	hsa-miR-548am-3p	91.303	NM_001167671
LPP	hsa-miR-548ah-3p	91.303	NM_001167671
LPP	hsa-miR-548j-3p	91.303	NM_001167671
LPP	hsa-miR-544b	91.126	NM_001167671
LPP	hsa-miR-576-5p	91.0523	NM_001167671
LPP	hsa-miR-570-5p	91.0508	NM_001167671
LPP	hsa-miR-548ai	91.0508	NM_001167671
LPP	hsa-miR-548ba	91.0508	NM_001167671
LPP	hsa-miR-186-5p	90.9746	NM_001167671
LPP	hsa-miR-3123	90.9133	NM_001167671
LPP	hsa-miR-3144-3p	90.8767	NM_001167671
LPP	hsa-miR-129-5p	90.8171	NM_001167671
LPP	hsa-miR-3714	90.7756	NM_001167671
LPP	hsa-miR-548c-3p	90.6247	NM_001167671
LPP	hsa-miR-6845-3p	90.5533	NM_001167671
LPP	hsa-miR-4263	90.4746	NM_001167671
LPP	hsa-miR-511-5p	90.3551	NM_001167671
LPP	hsa-miR-4768-5p	89.8741	NM_001167671
LPP	hsa-miR-587	89.8116	NM_001167671
LPP	hsa-miR-6817-3p	89.8101	NM_001167671
LPP	hsa-miR-96-5p	89.5975	NM_001167671

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Motifs and transcription factors (TFs) regulating LPP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LPP	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
LPP	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
LPP	hdpi__ETV4	ETV4 (directAnnotation).
LPP	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
LPP	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
LPP	jaspar__MA0079.5	SP1 (directAnnotation).
LPP	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
LPP	transfac_pro__M01299	MECP2 (directAnnotation).
LPP	transfac_pro__M06035	ZNF749 (directAnnotation).
LPP	metacluster_52.11	ZNF184 (directAnnotation).
LPP	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
LPP	transfac_pro__M07436	WT1 (directAnnotation).
LPP	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
LPP	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
LPP	transfac_pro__M02089	E2F3 (directAnnotation).
LPP	transfac_pro__M01122	ZNF219 (directAnnotation).
LPP	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
LPP	metacluster_44.7	NKX3-2 (directAnnotation).
LPP	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
LPP	transfac_pro__M08819	KLF2 (directAnnotation).
LPP	transfac_pro__M01175	ZBTB7B (directAnnotation).
LPP	transfac_pro__M01118	WT1 (directAnnotation).
LPP	swissregulon__hs__KLF6	KLF6 (directAnnotation).
LPP	transfac_pro__M01303	SP1 (directAnnotation).
LPP	transfac_pro__M00716	ZBTB14 (directAnnotation).
LPP	metacluster_133.2	CPSF4; CPSF4; E2F4; FOXO3; KLF13; KLF15; KLF17; KLF5; MAZ; MAZ; MAZ; MZF1; PATZ1; PATZ1; PATZ1; PATZ1; PLAG1; PRDM9; SP4; VEZF1; WT1; ZBTB17; ZBTB7A; ZBTB7A; ZBTB7B; ZNF148; ZNF148; ZNF148; ZNF148; ZNF180; ZNF180; ZNF202; ZNF219; ZNF219; ZNF263; ZNF263; ZNF28; ZNF281; ZNF281; ZNF281; ZNF281; ZNF281; ZNF383; ZNF398; ZNF398; ZNF444; ZNF444; ZNF467; ZNF543; ZNF543; ZNF641; ZNF692; ZNF737; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF880; ZNF880 (directAnnotation). MAZ; PLAG1; PLAGL1; SP1; SP5; SP5; ZBTB17; ZNF281; ZNF281; ZNF281; ZNF641; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
LPP	transfac_pro__M07397	ZNF148 (directAnnotation).
LPP	transfac_pro__M00807	EGR1; EGR2; EGR3 (directAnnotation).
LPP	transfac_pro__M00986	CHURC1 (directAnnotation).
LPP	metacluster_135.11	NR2C2 (directAnnotation).
LPP	cisbp__M00341	PAX6 (directAnnotation).
LPP	metacluster_198.3	ZFP64 (directAnnotation).
LPP	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
LPP	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
LPP	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
LPP	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
LPP	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
LPP	transfac_pro__M07260	IKZF1 (directAnnotation).
LPP	transfac_pro__M01835	KLF4 (directAnnotation).
LPP	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
LPP	swissregulon__hs__MTA3	MTA3 (directAnnotation).
LPP	cisbp__M07938	E2F1 (directAnnotation).
LPP	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
LPP	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
LPP	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
LPP	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
LPP	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
LPP	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
LPP	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
LPP	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."