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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LIN7C

Summary for LIN7C

Gene information	Gene symbol	LIN7C
	Ensembl ID	ENSG00000148943
	Entrez ID	55327
	Gene name	lin-7 homolog C, crumbs cell polarity complex component
	Synonyms	FLJ11215\|LIN-7-C\|LIN-7C\|MALS-3\|VELI3
	Gene type	protein_coding
	UniProtAcc	Q9NUP9

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Dataset with differentially expressed gene: LIN7C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.276525	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.270407	3.10e-23

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Expression of LIN7C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LIN7C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LIN7C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LIN7C	hsa-miR-196a-1-3p	84.0222	NM_018362
LIN7C	hsa-miR-548j-3p	83.949	NM_018362
LIN7C	hsa-miR-548aq-3p	83.949	NM_018362
LIN7C	hsa-miR-548ah-3p	83.949	NM_018362
LIN7C	hsa-miR-548am-3p	83.949	NM_018362
LIN7C	hsa-miR-548ae-3p	83.949	NM_018362
LIN7C	hsa-miR-551b-5p	83.6306	NM_018362
LIN7C	hsa-miR-3138	83.4891	NM_018362
LIN7C	hsa-miR-548p	82.9339	NM_018362
LIN7C	hsa-miR-330-3p	82.826	NM_018362
LIN7C	hsa-miR-4307	82.792	NM_018362
LIN7C	hsa-miR-4474-5p	82.7911	NM_018362
LIN7C	hsa-miR-548t-5p	82.6466	NM_018362
LIN7C	hsa-miR-548az-5p	82.6466	NM_018362
LIN7C	hsa-miR-4531	82.5431	NM_018362
LIN7C	hsa-miR-4528	82.4341	NM_018362
LIN7C	hsa-miR-548d-3p	81.9183	NM_018362
LIN7C	hsa-miR-548bb-3p	81.9183	NM_018362
LIN7C	hsa-miR-548h-3p	81.9183	NM_018362
LIN7C	hsa-miR-548ac	81.9183	NM_018362
LIN7C	hsa-miR-548z	81.9183	NM_018362
LIN7C	hsa-miR-6735-3p	81.822	NM_018362
LIN7C	hsa-miR-4263	81.549	NM_018362
LIN7C	hsa-miR-3529-3p	81.1957	NM_018362
LIN7C	hsa-miR-6875-3p	80.9944	NM_018362
LIN7C	hsa-miR-6882-3p	80.9466	NM_018362
LIN7C	hsa-miR-7110-5p	80.537	NM_018362
LIN7C	hsa-miR-6842-5p	80.537	NM_018362
LIN7C	hsa-miR-513c-3p	80.4748	NM_018362
LIN7C	hsa-miR-513a-3p	80.4748	NM_018362
LIN7C	hsa-miR-6752-5p	80.2611	NM_018362
LIN7C	hsa-miR-4422	80.2094	NM_018362
LIN7C	hsa-miR-3133	80.0952	NM_018362

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Motifs and transcription factors (TFs) regulating LIN7C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LIN7C	metacluster_7.13	ZFX (directAnnotation).
LIN7C	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
LIN7C	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
LIN7C	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
LIN7C	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."