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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LCOR

Summary for LCOR

Gene information	Gene symbol	LCOR
	Ensembl ID	ENSG00000196233
	Entrez ID	84458
	Gene name	ligand dependent nuclear receptor corepressor
	Synonyms	C10orf12\|DKFZP564P1916\|FLJ13022\|FLJ38026\|KIAA1795\|MLR2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: LCOR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.419597	4.88e-19
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.269672	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.473403	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.326516	9.81e-45
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.461597	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.288571	9.51e-34
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.330673	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.272627	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.346121	4.20e-34

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Expression of LCOR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LCOR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LCOR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LCOR	hsa-miR-548o-5p	91.1232	NM_001170765
LCOR	hsa-miR-548j-5p	91.1232	NM_001170765
LCOR	hsa-miR-548i	91.1232	NM_001170765
LCOR	hsa-miR-548aq-5p	91.1232	NM_001170765
LCOR	hsa-miR-548ae-5p	91.1232	NM_001170765
LCOR	hsa-miR-548y	91.1232	NM_001170765
LCOR	hsa-miR-548ay-5p	91.1232	NM_001170765
LCOR	hsa-miR-3973	91.0986	NM_001170765
LCOR	hsa-miR-3671	91.0855	NM_001170766
LCOR	hsa-miR-27a-3p	90.9019	NM_001170765
LCOR	hsa-miR-9985	90.9019	NM_001170765
LCOR	hsa-miR-27b-3p	90.9019	NM_001170765
LCOR	hsa-miR-4735-5p	90.5051	NM_001170765
LCOR	hsa-miR-1468-3p	90.4887	NM_001170765
LCOR	hsa-miR-3692-3p	90.1503	NM_001170765
LCOR	hsa-miR-6715b-3p	89.6483	NM_001170765
LCOR	hsa-miR-216b-5p	89.6251	NM_001170765
LCOR	hsa-miR-302c-3p	89.0517	NM_001170765
LCOR	hsa-miR-302a-3p	89.0517	NM_001170765
LCOR	hsa-miR-302d-3p	89.0517	NM_001170765
LCOR	hsa-miR-302b-3p	89.0517	NM_001170765
LCOR	hsa-miR-520e-3p	88.6704	NM_001170765
LCOR	hsa-miR-520b-3p	88.6704	NM_001170765
LCOR	hsa-miR-520c-3p	88.6704	NM_001170765
LCOR	hsa-miR-185-5p	88.26	NM_001170766
LCOR	hsa-miR-4644	88.26	NM_001170766
LCOR	hsa-miR-302c-5p	88.1126	NM_001170766
LCOR	hsa-miR-410-3p	88.0475	NM_001170765
LCOR	hsa-miR-500b-3p	88.0259	NM_001170765
LCOR	hsa-miR-4789-5p	87.9872	NM_001170765
LCOR	hsa-miR-196a-5p	87.9372	NM_001170765
LCOR	hsa-miR-196b-5p	87.9372	NM_001170765
LCOR	hsa-miR-2115-3p	87.8708	NM_001170765
LCOR	hsa-miR-520a-3p	87.7124	NM_001170765
LCOR	hsa-miR-520d-3p	87.7124	NM_001170765
LCOR	hsa-miR-373-3p	87.7124	NM_001170765
LCOR	hsa-miR-372-3p	87.7124	NM_001170765
LCOR	hsa-miR-6124	87.6137	NM_001170766
LCOR	hsa-miR-142-3p	87.2924	NM_001170765
LCOR	hsa-miR-372-5p	86.8343	NM_001170765
LCOR	hsa-miR-12122	86.7974	NM_001170765
LCOR	hsa-miR-144-3p	86.5013	NM_001170765
LCOR	hsa-miR-4473	86.3961	NM_001170766
LCOR	hsa-miR-146a-3p	86.3531	NM_001170765
LCOR	hsa-miR-5692a	86.0693	NM_001170765
LCOR	hsa-miR-10523-5p	85.9732	NM_001170765
LCOR	hsa-miR-4695-3p	85.9534	NM_001170765
LCOR	hsa-miR-10522-5p	85.9196	NM_001170765
LCOR	hsa-miR-4719	85.8897	NM_001170765
LCOR	hsa-miR-6715a-3p	85.8575	NM_001170765

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Motifs and transcription factors (TFs) regulating LCOR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LCOR	metacluster_7.13	ZFX (directAnnotation).
LCOR	cisbp__M01863	ZNF711 (inferredBy_Orthology).
LCOR	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
LCOR	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
LCOR	metacluster_151.2	ZNF23 (directAnnotation).
LCOR	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
LCOR	transfac_pro__M05479	ZNF580 (directAnnotation).
LCOR	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
LCOR	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
LCOR	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
LCOR	jaspar__MA0748.2	YY2 (directAnnotation).
LCOR	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
LCOR	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
LCOR	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
LCOR	jaspar__MA0079.5	SP1 (directAnnotation).
LCOR	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
LCOR	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
LCOR	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
LCOR	swissregulon__hs__CHD1	CHD1 (directAnnotation).
LCOR	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
LCOR	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
LCOR	transfac_pro__M12686	ZBTB10 (directAnnotation).
LCOR	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
LCOR	metacluster_143.14	ZNF320 (directAnnotation).
LCOR	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
LCOR	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
LCOR	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
LCOR	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
LCOR	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
LCOR	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
LCOR	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
LCOR	kznf__ZNF141_Imbeault2017_RP_RCADE	ZNF141 (directAnnotation).
LCOR	transfac_pro__M04617	ZBTB7A (directAnnotation).
LCOR	transfac_pro__M01973	PLAG1 (directAnnotation).
LCOR	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
LCOR	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
LCOR	metacluster_66.1	MTF1; ZNF320; ZNF320; ZNF320; ZNF782 (directAnnotation).
LCOR	cisbp__M01864	EGR1 (inferredBy_Orthology).
LCOR	tfdimers__MD00391	KLF4 (directAnnotation).
LCOR	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
LCOR	tfdimers__MD00151	CHURC1 (directAnnotation).
LCOR	transfac_pro__M04817	ZBTB33 (directAnnotation).
LCOR	cisbp__M00139	ZNF281 (inferredBy_Orthology).
LCOR	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
LCOR	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
LCOR	transfac_public__M00491	PATZ1 (directAnnotation).
LCOR	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
LCOR	metacluster_3.10	KLF2; KLF4 (directAnnotation).
LCOR	jaspar__MA1122.1	TFDP1 (directAnnotation).
LCOR	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."