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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LATS2

Summary for LATS2

Gene information	Gene symbol	LATS2
	Ensembl ID	ENSG00000150457
	Entrez ID	26524
	Gene name	large tumor suppressor kinase 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9NRM7

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Dataset with differentially expressed gene: LATS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.386438	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.403158	3.31e-12

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Expression of LATS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LATS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
LATS2	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating LATS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LATS2	hsa-miR-4324	90.4452	NM_014572
LATS2	hsa-miR-12120	90.4041	NM_014572
LATS2	hsa-miR-888-5p	90.0809	NM_014572
LATS2	hsa-miR-4735-5p	89.5497	NM_014572
LATS2	hsa-miR-135b-5p	89.5068	NM_014572
LATS2	hsa-miR-5692c	89.3509	NM_014572
LATS2	hsa-miR-5692b	89.3509	NM_014572
LATS2	hsa-miR-135a-5p	89.3378	NM_014572
LATS2	hsa-miR-342-3p	88.5977	NM_014572
LATS2	hsa-miR-3171	88.308	NM_014572
LATS2	hsa-miR-4700-3p	87.3903	NM_014572
LATS2	hsa-miR-520d-5p	87.3684	NM_014572
LATS2	hsa-miR-524-5p	87.3684	NM_014572
LATS2	hsa-miR-1257	87.2773	NM_014572
LATS2	hsa-miR-513a-5p	86.5052	NM_014572
LATS2	hsa-miR-767-3p	86.1524	NM_014572
LATS2	hsa-miR-22-5p	85.9862	NM_014572
LATS2	hsa-miR-12136	85.8678	NM_014572
LATS2	hsa-miR-4468	85.292	NM_014572
LATS2	hsa-miR-4526	85.0554	NM_014572
LATS2	hsa-miR-3660	85.0554	NM_014572
LATS2	hsa-miR-6883-3p	84.5062	NM_014572
LATS2	hsa-miR-6830-5p	84.4577	NM_014572
LATS2	hsa-miR-4645-3p	83.9473	NM_014572
LATS2	hsa-miR-8066	83.9059	NM_014572
LATS2	hsa-miR-103a-3p	83.5733	NM_014572
LATS2	hsa-miR-107	83.5733	NM_014572
LATS2	hsa-miR-4423-5p	83.4172	NM_014572
LATS2	hsa-miR-30b-5p	83.1283	NM_014572
LATS2	hsa-miR-30c-5p	83.1283	NM_014572
LATS2	hsa-miR-5009-3p	83.0549	NM_014572
LATS2	hsa-miR-3163	82.2488	NM_014572
LATS2	hsa-miR-6768-5p	82.2431	NM_014572
LATS2	hsa-miR-1261	81.8523	NM_014572
LATS2	hsa-miR-376c-5p	81.4375	NM_014572
LATS2	hsa-miR-376b-5p	81.4375	NM_014572
LATS2	hsa-miR-6847-3p	81.0834	NM_014572
LATS2	hsa-miR-4328	80.312	NM_014572

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Motifs and transcription factors (TFs) regulating LATS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LATS2	metacluster_7.13	ZFX (directAnnotation).
LATS2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
LATS2	metacluster_151.2	ZNF23 (directAnnotation).
LATS2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
LATS2	transfac_pro__M05479	ZNF580 (directAnnotation).
LATS2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
LATS2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
LATS2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
LATS2	metacluster_182.10	ZFX (directAnnotation).
LATS2	transfac_pro__M06071	ZNF814 (directAnnotation).
LATS2	jaspar__MA0748.2	YY2 (directAnnotation).
LATS2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
LATS2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
LATS2	jaspar__MA0079.5	SP1 (directAnnotation).
LATS2	metacluster_135.11	NR2C2 (directAnnotation).
LATS2	tfdimers__MD00038	TFAP2C (directAnnotation).
LATS2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
LATS2	cisbp__M00968	MTF2 (directAnnotation).
LATS2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
LATS2	cisbp__M00341	PAX6 (directAnnotation).
LATS2	metacluster_198.3	ZFP64 (directAnnotation).
LATS2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
LATS2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
LATS2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
LATS2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
LATS2	cisbp__M00788	ZFY (inferredBy_Orthology).
LATS2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
LATS2	metacluster_175.1	ZNF283 (directAnnotation).
LATS2	hdpi__ZNF304	ZNF304 (directAnnotation).
LATS2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
LATS2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
LATS2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
LATS2	transfac_pro__M01199	TRIM28 (directAnnotation).
LATS2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
LATS2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
LATS2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
LATS2	transfac_pro__M03806	ZBTB7C (directAnnotation).
LATS2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."