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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: LATS1

Summary for LATS1

Gene information	Gene symbol	LATS1
	Ensembl ID	ENSG00000131023
	Entrez ID	9113
	Gene name	large tumor suppressor kinase 1
	Synonyms	WARTS
	Gene type	protein_coding
	UniProtAcc	O95835

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Dataset with differentially expressed gene: LATS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.279146	4.05e-20
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	B cells	-0.393664	4.41e-05

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Expression of LATS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LATS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LATS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LATS1	hsa-miR-181b-5p	94.7828	NM_004690
LATS1	hsa-miR-4666a-3p	94.5232	NM_004690
LATS1	hsa-miR-4760-5p	94.3875	NM_004690
LATS1	hsa-miR-3646	94.2997	NM_004690
LATS1	hsa-miR-15a-5p	94.2347	NM_004690
LATS1	hsa-miR-6838-5p	94.2347	NM_004690
LATS1	hsa-miR-15b-5p	94.2347	NM_004690
LATS1	hsa-miR-6832-3p	94.1105	NM_004690
LATS1	hsa-miR-539-5p	94.0776	NM_004690
LATS1	hsa-miR-5002-5p	93.8761	NM_004690
LATS1	hsa-miR-4704-5p	93.599	NM_004690
LATS1	hsa-miR-8061	93.517	NM_004690
LATS1	hsa-miR-497-5p	93.1266	NM_004690
LATS1	hsa-miR-424-5p	93.1266	NM_004690
LATS1	hsa-miR-153-3p	92.7242	NM_004690
LATS1	hsa-miR-922	91.9268	NM_004690
LATS1	hsa-miR-4297	91.4417	NM_004690
LATS1	hsa-miR-6128	90.4532	NM_004690
LATS1	hsa-miR-642b-5p	89.5694	NM_004690
LATS1	hsa-miR-548g-3p	89.3666	NM_004690
LATS1	hsa-miR-3688-3p	88.6968	NM_004690
LATS1	hsa-miR-4482-3p	88.5692	NM_004690
LATS1	hsa-miR-4668-5p	88.363	NM_004690
LATS1	hsa-miR-12123	87.4347	NM_004690
LATS1	hsa-miR-6830-3p	87.0126	NM_004690
LATS1	hsa-miR-524-5p	86.8741	NM_004690
LATS1	hsa-miR-520d-5p	86.8741	NM_004690
LATS1	hsa-miR-616-5p	86.7946	NM_004690
LATS1	hsa-miR-371b-5p	86.7946	NM_004690
LATS1	hsa-miR-373-5p	86.7946	NM_004690
LATS1	hsa-miR-338-5p	86.7916	NM_004690
LATS1	hsa-miR-211-5p	86.4828	NM_004690
LATS1	hsa-miR-204-5p	86.4828	NM_004690
LATS1	hsa-miR-3121-3p	86.3945	NM_004690
LATS1	hsa-miR-6815-3p	86.3358	NM_004690
LATS1	hsa-miR-6732-5p	85.9382	NM_004690
LATS1	hsa-miR-518a-5p	85.8115	NM_004690
LATS1	hsa-miR-527	85.8115	NM_004690
LATS1	hsa-let-7f-2-3p	85.7792	NM_004690
LATS1	hsa-miR-1185-1-3p	85.7501	NM_004690
LATS1	hsa-miR-1185-2-3p	85.7501	NM_004690
LATS1	hsa-miR-3124-3p	85.7269	NM_004690
LATS1	hsa-miR-6504-3p	85.2812	NM_004690
LATS1	hsa-miR-10399-5p	85.2812	NM_004690
LATS1	hsa-miR-19b-2-5p	84.8388	NM_004690
LATS1	hsa-miR-19b-1-5p	84.8388	NM_004690
LATS1	hsa-miR-19a-5p	84.8388	NM_004690
LATS1	hsa-miR-5581-5p	84.5132	NM_004690
LATS1	hsa-miR-5692a	84.1778	NM_004690
LATS1	hsa-miR-381-3p	83.1147	NM_004690

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Motifs and transcription factors (TFs) regulating LATS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LATS1	metacluster_119.2	CCNT2; GATA1; GATA1; GATA1; GATA1; GATA2; GATA2; GATA2; NCOA1; TAL1; TAL1; TAL1; TAL1; ZNF823 (directAnnotation). GATA1; TAL1; TAL1; TAL1; TAL1 (inferredBy_Orthology).
LATS1	taipale_tf_pairs__HOXB13_ONECUT2_NNNRTAAAWATYGAYY_HT	HOXB13; ONECUT2 (directAnnotation).
LATS1	transfac_pro__M06277	ZNF404 (directAnnotation).
LATS1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
LATS1	metacluster_7.13	ZFX (directAnnotation).
LATS1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
LATS1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
LATS1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
LATS1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
LATS1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
LATS1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
LATS1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
LATS1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
LATS1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
LATS1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
LATS1	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).
LATS1	transfac_pro__M05432	ZSCAN18 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
LATS1	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."