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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KPNA3

Summary for KPNA3

Gene information	Gene symbol	KPNA3
	Ensembl ID	ENSG00000102753
	Entrez ID	3839
	Gene name	karyopherin subunit alpha 3
	Synonyms	hSRP1\|IPOA4\|SRP1gamma\|SRP4
	Gene type	protein_coding
	UniProtAcc	O00505

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Dataset with differentially expressed gene: KPNA3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.436477	9.99e-37

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Expression of KPNA3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KPNA3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KPNA3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KPNA3	hsa-miR-545-5p	88.4989	NM_002267
KPNA3	hsa-miR-219a-1-3p	88.4927	NM_002267
KPNA3	hsa-miR-590-3p	88.3151	NM_002267
KPNA3	hsa-miR-4799-5p	88.2368	NM_002267
KPNA3	hsa-miR-5700	88.2198	NM_002267
KPNA3	hsa-miR-331-5p	88.2182	NM_002267
KPNA3	hsa-miR-186-5p	88.0295	NM_002267
KPNA3	hsa-miR-1251-5p	87.9351	NM_002267
KPNA3	hsa-miR-1261	87.6402	NM_002267
KPNA3	hsa-miR-542-3p	87.0861	NM_002267
KPNA3	hsa-miR-4793-3p	87.0382	NM_002267
KPNA3	hsa-miR-4456	86.6061	NM_002267
KPNA3	hsa-miR-195-5p	86.2076	NM_002267
KPNA3	hsa-miR-15b-5p	86.2076	NM_002267
KPNA3	hsa-miR-503-5p	86.2076	NM_002267
KPNA3	hsa-miR-15a-5p	86.2076	NM_002267
KPNA3	hsa-miR-16-5p	86.2076	NM_002267
KPNA3	hsa-miR-888-5p	86.0843	NM_002267
KPNA3	hsa-miR-1910-3p	85.8358	NM_002267
KPNA3	hsa-let-7f-1-3p	85.7388	NM_002267
KPNA3	hsa-let-7b-3p	85.7388	NM_002267
KPNA3	hsa-miR-98-3p	85.7388	NM_002267
KPNA3	hsa-let-7a-3p	85.7388	NM_002267
KPNA3	hsa-miR-7973	85.6642	NM_002267
KPNA3	hsa-miR-9985	85.545	NM_002267
KPNA3	hsa-miR-27b-3p	85.545	NM_002267
KPNA3	hsa-miR-27a-3p	85.545	NM_002267
KPNA3	hsa-miR-10524-5p	84.1012	NM_002267
KPNA3	hsa-miR-6859-5p	83.3008	NM_002267
KPNA3	hsa-miR-5582-5p	82.6128	NM_002267
KPNA3	hsa-miR-5186	82.0367	NM_002267
KPNA3	hsa-miR-3160-5p	81.8637	NM_002267
KPNA3	hsa-miR-548an	81.5683	NM_002267
KPNA3	hsa-miR-2467-5p	81.1307	NM_002267
KPNA3	hsa-miR-551b-5p	80.9621	NM_002267
KPNA3	hsa-miR-548t-5p	80.7775	NM_002267
KPNA3	hsa-miR-548az-5p	80.7775	NM_002267
KPNA3	hsa-miR-5189-3p	80.6617	NM_002267
KPNA3	hsa-miR-891a-3p	80.3488	NM_002267
KPNA3	hsa-miR-20a-5p	80.2932	NM_002267
KPNA3	hsa-miR-106b-5p	80.2932	NM_002267
KPNA3	hsa-miR-4275	80.2285	NM_002267
KPNA3	hsa-miR-3130-5p	80.1785	NM_002267
KPNA3	hsa-miR-127-5p	80.042	NM_002267

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Motifs and transcription factors (TFs) regulating KPNA3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KPNA3	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
KPNA3	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
KPNA3	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
KPNA3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
KPNA3	transfac_pro__M00652	NRF1 (directAnnotation).
KPNA3	transfac_pro__M04918	EGR1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."