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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KPNA1

Summary for KPNA1

Gene information	Gene symbol	KPNA1
	Ensembl ID	ENSG00000114030
	Entrez ID	3836
	Gene name	karyopherin subunit alpha 1
	Synonyms	IPOA5\|NPI-1\|RCH2\|SRP1
	Gene type	protein_coding
	UniProtAcc	P52294

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Dataset with differentially expressed gene: KPNA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.263458	4.08e-28

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Expression of KPNA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KPNA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KPNA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KPNA1	hsa-miR-577	86.3381	NM_002264
KPNA1	hsa-miR-4276	86.2614	NM_002264
KPNA1	hsa-miR-6516-5p	86.1736	NM_002264
KPNA1	hsa-miR-383-3p	86.0829	NM_002264
KPNA1	hsa-miR-5680	86.0686	NM_002264
KPNA1	hsa-miR-520h	85.3956	NM_002264
KPNA1	hsa-miR-520g-3p	85.3956	NM_002264
KPNA1	hsa-miR-649	85.0819	NM_002264
KPNA1	hsa-miR-181d-5p	84.8293	NM_002264
KPNA1	hsa-miR-181a-5p	84.8293	NM_002264
KPNA1	hsa-miR-181c-5p	84.8293	NM_002264
KPNA1	hsa-miR-181b-5p	84.8293	NM_002264
KPNA1	hsa-miR-6508-5p	84.7162	NM_002264
KPNA1	hsa-miR-33a-3p	84.3596	NM_002264
KPNA1	hsa-miR-3923	84.3374	NM_002264
KPNA1	hsa-miR-548c-3p	84.292	NM_002264
KPNA1	hsa-miR-548p	84.2687	NM_002264
KPNA1	hsa-miR-4291	84.0033	NM_002264
KPNA1	hsa-miR-6165	83.8219	NM_002264
KPNA1	hsa-miR-8067	83.5283	NM_002264
KPNA1	hsa-miR-548n	83.4433	NM_002264
KPNA1	hsa-miR-934	83.1535	NM_002264
KPNA1	hsa-miR-10393-5p	83.0019	NM_002264
KPNA1	hsa-miR-186-5p	82.8535	NM_002264
KPNA1	hsa-miR-525-5p	82.8252	NM_002264
KPNA1	hsa-miR-520a-5p	82.8252	NM_002264
KPNA1	hsa-miR-4659a-3p	82.3145	NM_002264
KPNA1	hsa-miR-4659b-3p	82.3145	NM_002264
KPNA1	hsa-miR-549a-3p	82.2352	NM_002264
KPNA1	hsa-miR-580-3p	81.995	NM_002264
KPNA1	hsa-miR-378a-5p	81.7469	NM_002264
KPNA1	hsa-miR-548e-5p	81.6845	NM_002264
KPNA1	hsa-miR-511-3p	81.6635	NM_002264
KPNA1	hsa-miR-6780b-3p	81.4656	NM_002264
KPNA1	hsa-miR-144-3p	81.4331	NM_002264
KPNA1	hsa-miR-634	81.4001	NM_002264
KPNA1	hsa-miR-3065-5p	81.3892	NM_002264
KPNA1	hsa-miR-3619-5p	81.339	NM_002264
KPNA1	hsa-miR-5571-5p	81.326	NM_002264
KPNA1	hsa-miR-4685-3p	81.2573	NM_002264
KPNA1	hsa-miR-4287	81.2573	NM_002264
KPNA1	hsa-miR-12136	81.2506	NM_002264
KPNA1	hsa-miR-545-5p	81.1953	NM_002264
KPNA1	hsa-miR-143-5p	81.0594	NM_002264
KPNA1	hsa-miR-7151-3p	80.7564	NM_002264
KPNA1	hsa-miR-3929	80.2153	NM_002264
KPNA1	hsa-miR-4478	80.2153	NM_002264
KPNA1	hsa-miR-214-3p	80.1935	NM_002264
KPNA1	hsa-miR-761	80.1935	NM_002264
KPNA1	hsa-miR-4751	80.0683	NM_002264

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Motifs and transcription factors (TFs) regulating KPNA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KPNA1	metacluster_7.13	ZFX (directAnnotation).
KPNA1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
KPNA1	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
KPNA1	metacluster_151.2	ZNF23 (directAnnotation).
KPNA1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
KPNA1	transfac_pro__M05479	ZNF580 (directAnnotation).
KPNA1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
KPNA1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
KPNA1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
KPNA1	metacluster_182.10	ZFX (directAnnotation).
KPNA1	hdpi__ETV4	ETV4 (directAnnotation).
KPNA1	jaspar__MA0748.2	YY2 (directAnnotation).
KPNA1	transfac_pro__M05628	ZNF735 (directAnnotation).
KPNA1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
KPNA1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
KPNA1	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
KPNA1	jaspar__MA0079.5	SP1 (directAnnotation).
KPNA1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."