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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KMT5B

Summary for KMT5B

Gene information	Gene symbol	KMT5B
	Ensembl ID	ENSG00000110066
	Entrez ID	51111
	Gene name	lysine methyltransferase 5B
	Synonyms	CGI-85\|SUV420H1
	Gene type	protein_coding
	UniProtAcc	Q4FZB7

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Dataset with differentially expressed gene: KMT5B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.279359	8.91e-17

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Expression of KMT5B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KMT5B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KMT5B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KMT5B	hsa-miR-4777-3p	88.4191	NM_001300908
KMT5B	hsa-miR-3915	88.1745	NM_001300907
KMT5B	hsa-miR-7110-3p	88.1182	NM_016028
KMT5B	hsa-miR-449b-3p	87.9907	NM_001300907
KMT5B	hsa-miR-345-5p	87.6141	NM_001300908
KMT5B	hsa-miR-5003-3p	87.4184	NM_016028
KMT5B	hsa-miR-206	86.9204	NM_016028
KMT5B	hsa-miR-1-3p	86.9204	NM_016028
KMT5B	hsa-miR-4753-3p	86.7737	NM_016028
KMT5B	hsa-miR-4317	86.5981	NM_001300907
KMT5B	hsa-miR-92a-3p	86.3777	NM_001300907
KMT5B	hsa-miR-363-3p	86.3777	NM_001300907
KMT5B	hsa-miR-367-3p	86.3777	NM_001300907
KMT5B	hsa-miR-32-5p	86.3777	NM_001300907
KMT5B	hsa-miR-25-3p	86.3777	NM_001300907
KMT5B	hsa-miR-92b-3p	86.3777	NM_001300907
KMT5B	hsa-miR-4718	86.2445	NM_001300907
KMT5B	hsa-miR-4766-5p	86.0998	NM_016028
KMT5B	hsa-miR-4709-5p	86.0404	NM_016028
KMT5B	hsa-miR-613	85.9622	NM_016028
KMT5B	hsa-miR-4299	85.5068	NM_001300907
KMT5B	hsa-miR-3529-3p	85.3575	NM_001300907
KMT5B	hsa-miR-548k	85.0689	NM_001300907
KMT5B	hsa-miR-548av-5p	85.0689	NM_001300907
KMT5B	hsa-miR-6809-3p	83.2745	NM_016028
KMT5B	hsa-miR-8054	83.2557	NM_001300907
KMT5B	hsa-miR-4747-5p	83.1326	NM_001300907
KMT5B	hsa-miR-5196-5p	83.1326	NM_001300907
KMT5B	hsa-miR-6818-5p	82.6646	NM_016028
KMT5B	hsa-miR-4753-5p	82.5422	NM_001300907
KMT5B	hsa-miR-4302	82.4588	NM_001300907
KMT5B	hsa-miR-9985	82.3526	NM_001300907
KMT5B	hsa-miR-27a-3p	82.3526	NM_001300907
KMT5B	hsa-miR-513a-5p	82.3526	NM_001300907
KMT5B	hsa-miR-27b-3p	82.3526	NM_001300907
KMT5B	hsa-miR-510-3p	82.2107	NM_001300907
KMT5B	hsa-miR-148a-5p	82.1767	NM_001300908
KMT5B	hsa-miR-548b-3p	82.1482	NM_001300907
KMT5B	hsa-miR-3120-3p	81.973	NM_001300907
KMT5B	hsa-miR-548p	81.9005	NM_001300907
KMT5B	hsa-miR-372-5p	81.7139	NM_001300908
KMT5B	hsa-miR-338-5p	81.5386	NM_001300907
KMT5B	hsa-miR-4638-3p	81.3275	NM_016028
KMT5B	hsa-miR-6817-3p	81.1814	NM_016028
KMT5B	hsa-miR-140-3p	80.9597	NM_001300908
KMT5B	hsa-miR-526b-3p	80.6126	NM_001300907
KMT5B	hsa-miR-106a-5p	80.6126	NM_001300907
KMT5B	hsa-miR-5007-5p	80.4856	NM_016028
KMT5B	hsa-miR-93-5p	80.4461	NM_001300907
KMT5B	hsa-miR-519d-3p	80.4461	NM_001300907

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Motifs and transcription factors (TFs) regulating KMT5B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KMT5B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
KMT5B	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
KMT5B	metacluster_7.13	ZFX (directAnnotation).
KMT5B	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
KMT5B	cisbp__M00968	MTF2 (directAnnotation).
KMT5B	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
KMT5B	metacluster_160.20	JUND; PRDM15 (directAnnotation).
KMT5B	cisbp__M00341	PAX6 (directAnnotation).
KMT5B	metacluster_198.3	ZFP64 (directAnnotation).
KMT5B	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
KMT5B	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
KMT5B	cisbp__M00788	ZFY (inferredBy_Orthology).
KMT5B	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
KMT5B	hdpi__ZNF304	ZNF304 (directAnnotation).
KMT5B	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
KMT5B	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
KMT5B	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
KMT5B	transfac_pro__M01199	TRIM28 (directAnnotation).
KMT5B	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
KMT5B	metacluster_151.2	ZNF23 (directAnnotation).
KMT5B	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
KMT5B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
KMT5B	transfac_pro__M03806	ZBTB7C (directAnnotation).
KMT5B	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."