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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KLHL28

Summary for KLHL28

Gene information	Gene symbol	KLHL28
	Ensembl ID	ENSG00000179454
	Entrez ID	54813
	Gene name	kelch like family member 28
	Synonyms	BTBD5\|FLJ20081
	Gene type	protein_coding
	UniProtAcc	Q9NXS3

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Dataset with differentially expressed gene: KLHL28

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.526771	0.00e+00

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Expression of KLHL28 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KLHL28

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KLHL28

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KLHL28	hsa-miR-548a-3p	87.607	NM_001308112
KLHL28	hsa-miR-4668-3p	87.5221	NM_001308112
KLHL28	hsa-miR-548ap-3p	86.8689	NM_001308112
KLHL28	hsa-miR-548aa	86.8689	NM_001308112
KLHL28	hsa-miR-548t-3p	86.8689	NM_001308112
KLHL28	hsa-miR-4665-5p	86.3115	NM_001308112
KLHL28	hsa-miR-6792-5p	86.3075	NM_001308112
KLHL28	hsa-miR-3973	86.2471	NM_001308112
KLHL28	hsa-miR-374a-5p	86.2218	NM_001308112
KLHL28	hsa-miR-548k	86.1479	NM_001308112
KLHL28	hsa-miR-548av-5p	86.1479	NM_001308112
KLHL28	hsa-miR-8054	86.1479	NM_001308112
KLHL28	hsa-miR-625-5p	86.1247	NM_001308112
KLHL28	hsa-miR-4719	85.4699	NM_001308112
KLHL28	hsa-miR-5011-5p	85.4129	NM_001308112
KLHL28	hsa-miR-374b-5p	85.0515	NM_001308112
KLHL28	hsa-miR-8065	84.9461	NM_001308112
KLHL28	hsa-miR-6507-5p	84.6221	NM_001308112
KLHL28	hsa-miR-544b	84.5621	NM_001308112
KLHL28	hsa-miR-29b-1-5p	84.116	NM_001308112
KLHL28	hsa-miR-23b-3p	83.9447	NM_001308112
KLHL28	hsa-miR-23c	83.9447	NM_001308112
KLHL28	hsa-miR-23a-3p	83.9447	NM_001308112
KLHL28	hsa-miR-4257	83.8522	NM_001308112
KLHL28	hsa-miR-4668-5p	83.8171	NM_001308112
KLHL28	hsa-miR-767-5p	83.8072	NM_001308112
KLHL28	hsa-miR-4282	83.6556	NM_001308112
KLHL28	hsa-miR-374b-3p	83.4512	NM_001308112
KLHL28	hsa-miR-548aj-3p	82.3805	NM_001308112
KLHL28	hsa-miR-548ae-3p	82.3805	NM_001308112
KLHL28	hsa-miR-548x-3p	82.3805	NM_001308112
KLHL28	hsa-miR-548aq-3p	82.3805	NM_001308112
KLHL28	hsa-miR-4450	82.3104	NM_001308112
KLHL28	hsa-miR-628-3p	82.209	NM_001308112
KLHL28	hsa-miR-9983-3p	82.1535	NM_001308112
KLHL28	hsa-miR-519b-3p	82.0282	NM_001308112
KLHL28	hsa-miR-519c-3p	82.0282	NM_001308112
KLHL28	hsa-miR-519a-3p	82.0282	NM_001308112
KLHL28	hsa-miR-302d-5p	81.5318	NM_001308112
KLHL28	hsa-miR-302b-5p	81.5318	NM_001308112
KLHL28	hsa-miR-8068	81.4806	NM_001308112
KLHL28	hsa-miR-4789-3p	81.107	NM_001308112
KLHL28	hsa-miR-1252-3p	80.7682	NM_001308112
KLHL28	hsa-miR-7856-5p	80.7347	NM_001308112
KLHL28	hsa-miR-7844-5p	80.5503	NM_001308112
KLHL28	hsa-miR-4724-5p	80.1021	NM_001308112

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Motifs and transcription factors (TFs) regulating KLHL28

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."