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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: KLF10

Summary for KLF10

Gene information	Gene symbol	KLF10
	Ensembl ID	ENSG00000155090
	Entrez ID	7071
	Gene name	KLF transcription factor 10
	Synonyms	EGRA\|TIEG\|TIEG1
	Gene type	protein_coding
	UniProtAcc	Q13118

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Dataset with differentially expressed gene: KLF10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.25505	5.97e-17
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.367981	8.81e-06
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.521222	9.25e-23
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	cDCs	-0.271204	2.19e-03
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.28796	1.96e-14
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	Mono/Macro	-0.394853	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.25254	2.98e-09
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.253749	1.62e-29
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.379354	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Mono/Macro	-0.305407	2.24e-44
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	B cells	-0.360254	3.12e-02
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.352205	6.79e-18
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.411396	7.54e-29
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.479737	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.608675	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	-0.260904	1.27e-08
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.312388	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.271158	5.38e-13
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.471607	8.06e-23
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.259189	0.00e+00

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Expression of KLF10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KLF10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KLF10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KLF10	hsa-miR-4457	83.9686	NM_005655
KLF10	hsa-miR-3065-5p	83.295	NM_005655
KLF10	hsa-miR-6828-5p	83.1154	NM_001032282
KLF10	hsa-miR-6499-3p	82.1269	NM_001032282
KLF10	hsa-miR-548f-5p	82.0457	NM_005655
KLF10	hsa-miR-614	81.993	NM_005655
KLF10	hsa-miR-4762-5p	81.8915	NM_005655
KLF10	hsa-miR-607	81.5823	NM_005655
KLF10	hsa-miR-6508-5p	81.4003	NM_005655
KLF10	hsa-miR-618	80.3567	NM_005655
KLF10	hsa-miR-6074	80.2754	NM_005655
KLF10	hsa-miR-4501	80.0652	NM_005655

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Motifs and transcription factors (TFs) regulating KLF10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KLF10	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
KLF10	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
KLF10	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
KLF10	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
KLF10	transfac_pro__M06643	ZNF583 (directAnnotation).
KLF10	tfdimers__MD00567	IKZF2 (directAnnotation).
KLF10	transfac_pro__M04844	MAX (directAnnotation).
KLF10	swissregulon__hs__CEBPB	CEBPB (directAnnotation).
KLF10	transfac_pro__M04761	HSF1 (directAnnotation).
KLF10	jaspar__MA1125.1	ZNF384 (directAnnotation).
KLF10	taipale_tf_pairs__ERF_SREBF2_NNCACGTGACMGGAARNN_CAP_repr	ERF; SREBF2 (directAnnotation).
KLF10	hocomoco__CPEB1_HUMAN.H11MO.0.D	CPEB1 (directAnnotation).
KLF10	metacluster_46.5	HLF; TEF (directAnnotation).
KLF10	transfac_pro__M01297	HOXA13 (directAnnotation).
KLF10	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
KLF10	tfdimers__MD00006	FOXA1; FOXA2; FOXA3; NR3C1; PGR (directAnnotation).
KLF10	cisbp__M01815	CEBPE (inferredBy_Orthology).
KLF10	metacluster_130.2	ZNF182; ZNF22; ZNF225; ZNF225; ZNF285; ZNF362; ZNF362; ZNF384; ZNF487; ZNF512; ZNF570; ZNF613 (directAnnotation). ZNF384 (inferredBy_Orthology).
KLF10	metacluster_31.6	ZNF569 (directAnnotation). ZNF569 (inferredBy_Orthology).
KLF10	metacluster_178.10	POU2F2; POU4F1; POU4F1; POU4F2; POU4F2; POU4F3; POU4F3 (directAnnotation). CCDC160; HDX; POU1F1; POU2F1; POU2F2; POU3F1; POU3F2; POU3F3; POU3F4; POU4F1; POU4F2; POU4F3; POU5F1; POU5F1B; POU5F2; POU6F1; POU6F2 (inferredBy_Orthology).
KLF10	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
KLF10	tfdimers__MD00423	ARID3A; PAX4 (directAnnotation).
KLF10	transfac_pro__M12588	DDIT3 (directAnnotation).
KLF10	kznf__ZKSCAN2_Imbeault2017_OM_RCADE	ZKSCAN2 (directAnnotation).
KLF10	tfdimers__MD00285	PDX1; SMAD1 (directAnnotation).
KLF10	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
KLF10	tfdimers__MD00208	IRF1; LTF (directAnnotation).
KLF10	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
KLF10	metacluster_161.31	PRRX2 (directAnnotation).
KLF10	transfac_pro__M01660	GABPA (directAnnotation).
KLF10	taipale_tf_pairs__GCM1_CEBPB_MTRSGGGNNNNNNTTRCGYAAN_CAP	CEBPB; GCM1 (directAnnotation).
KLF10	hocomoco__HSFY1_HUMAN.H11MO.0.D	HSFY1; HSFY2 (directAnnotation).
KLF10	homer__ATTGCGCAAC_CEBP	CEBPB (inferredBy_Orthology).
KLF10	metacluster_46.4	CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; DBP; DBP; EP300; GATAD2A; HES2 (directAnnotation). CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; HLF; HLF (inferredBy_Orthology).
KLF10	metacluster_156.3	DBP; DBP; DBP; DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; TEF; TEF; TEF; TEF; TEF (directAnnotation). DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFILZ; NFILZ; TEF; TEF; TEF; TEF (inferredBy_Orthology).
KLF10	metacluster_156.4	NFIL3 (directAnnotation). NFIL3 (inferredBy_Orthology).
KLF10	metacluster_29.4	BCL6; BCL6; BCL6; BCL6; BCL6B; BCL6B; BCL6B; BCL6B; BCL6B (directAnnotation). BCL6; BCL6; BCL6 (inferredBy_Orthology).
KLF10	taipale_tf_pairs__GCM1_CEBPB_MTRSGGGNNNNNTTRCGYAAN_CAP	CEBPB; GCM1 (directAnnotation).
KLF10	tfdimers__MD00330	FOXP3; HSF1 (directAnnotation).
KLF10	taipale_cyt_meth__VENTX_CGATTATCG_FL_repr	VENTX (directAnnotation).
KLF10	cisbp__M01816	JUN (inferredBy_Orthology).
KLF10	transfac_public__M00040	ATF2 (directAnnotation).
KLF10	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
KLF10	kznf__CTCF_Rhee2011.2_ChIP-exo	CTCF (directAnnotation).
KLF10	metacluster_32.24	ZNF287 (directAnnotation).
KLF10	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
KLF10	jaspar__MA0502.2	NFYB (directAnnotation).
KLF10	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
KLF10	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
KLF10	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
KLF10	metacluster_170.2	up	B cells	GSE169246_PacAteTissue	post
KLF10	metacluster_163.1	up	B cells	GSE169246_PacAteTissue	post
KLF10	transfac_pro__M07461	up	B cells	GSE169246_PacAteTissue	post
KLF10	metacluster_195.2	up	B cells	GSE169246_PacAteTissue	post
KLF10	metacluster_170.2	up	Malignant cells	GSE189460	pre
KLF10	metacluster_195.2	up	Malignant cells	GSE189460	pre
KLF10	metacluster_3.3	up	Malignant cells	GSE189460	pre
KLF10	metacluster_163.1	down	Malignant cells	GSE199333	pre
KLF10	metacluster_170.2	down	Malignant cells	GSE199333	pre
KLF10	metacluster_195.2	down	Malignant cells	GSE199333	pre

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."