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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KDM5A

Summary for KDM5A

Gene information	Gene symbol	KDM5A
	Ensembl ID	ENSG00000073614
	Entrez ID	5927
	Gene name	lysine demethylase 5A
	Synonyms	JARID1A\|RBBP2
	Gene type	protein_coding
	UniProtAcc	P29375

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Dataset with differentially expressed gene: KDM5A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.330402	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.290187	5.58e-34
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.507498	0.00e+00

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Expression of KDM5A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KDM5A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KDM5A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KDM5A	hsa-miR-199b-3p	85.1858	NM_001042603
KDM5A	hsa-miR-409-5p	85.1353	NM_001042603
KDM5A	hsa-miR-4761-3p	84.6936	NM_001042603
KDM5A	hsa-miR-4502	84.3494	NM_001042603
KDM5A	hsa-miR-1246	84.1797	NM_001042603
KDM5A	hsa-miR-138-5p	83.7964	NM_001042603
KDM5A	hsa-miR-5692a	83.7184	NM_001042603
KDM5A	hsa-miR-3167	83.6265	NM_001042603
KDM5A	hsa-miR-3919	83.273	NM_001042603
KDM5A	hsa-miR-224-5p	83.0082	NM_001042603
KDM5A	hsa-miR-543	82.7968	NM_001042603
KDM5A	hsa-miR-671-5p	82.7539	NM_001042603
KDM5A	hsa-miR-101-3p	82.444	NM_001042603
KDM5A	hsa-miR-3681-5p	82.3619	NM_001042603
KDM5A	hsa-miR-6849-5p	82.3067	NM_001042603
KDM5A	hsa-miR-3065-3p	82.0327	NM_001042603
KDM5A	hsa-miR-3129-5p	81.9656	NM_001042603
KDM5A	hsa-miR-4755-5p	81.8021	NM_001042603
KDM5A	hsa-miR-5006-3p	81.8021	NM_001042603
KDM5A	hsa-miR-3190-3p	81.2532	NM_001042603
KDM5A	hsa-miR-6770-5p	81.1266	NM_001042603
KDM5A	hsa-miR-6882-5p	81.0566	NM_001042603

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Motifs and transcription factors (TFs) regulating KDM5A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KDM5A	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
KDM5A	hdpi__ETV4	ETV4 (directAnnotation).
KDM5A	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
KDM5A	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
KDM5A	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
KDM5A	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
KDM5A	tfdimers__MD00391	KLF4 (directAnnotation).
KDM5A	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
KDM5A	tfdimers__MD00441	OVOL2; RELA (directAnnotation).
KDM5A	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."