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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: KCNN3

Summary for KCNN3

Gene information	Gene symbol	KCNN3
	Ensembl ID	ENSG00000143603
	Entrez ID	3782
	Gene name	potassium calcium-activated channel subfamily N member 3
	Synonyms	hSK3\|KCa2.3\|SKCA3
	Gene type	protein_coding
	UniProtAcc	Q9UGI6

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Dataset with differentially expressed gene: KCNN3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	3.88218	2.94e-03
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.261703	0.00e+00

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Expression of KCNN3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KCNN3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KCNN3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KCNN3	hsa-miR-3681-3p	84.4353	NM_001204087
KCNN3	hsa-miR-203b-5p	84.3706	NM_001204087
KCNN3	hsa-miR-6718-5p	84.3706	NM_001204087
KCNN3	hsa-miR-3667-5p	84.2674	NM_170782
KCNN3	hsa-miR-548p	84.2355	NM_170782
KCNN3	hsa-miR-132-3p	84.0178	NM_001204087
KCNN3	hsa-miR-212-3p	84.0178	NM_001204087
KCNN3	hsa-miR-101-3p	83.9788	NM_001204087
KCNN3	hsa-miR-4794	83.8392	NM_001204087
KCNN3	hsa-miR-548ao-3p	83.8362	NM_170782
KCNN3	hsa-miR-4768-3p	83.7965	NM_170782
KCNN3	hsa-miR-1277-5p	83.7645	NM_001204087
KCNN3	hsa-miR-4531	83.6365	NM_170782
KCNN3	hsa-miR-498-5p	83.6153	NM_001204087
KCNN3	hsa-miR-143-3p	83.5304	NM_170782
KCNN3	hsa-miR-590-3p	83.4333	NM_170782
KCNN3	hsa-miR-4777-5p	83.2076	NM_170782
KCNN3	hsa-miR-3126-3p	82.9035	NM_001204087
KCNN3	hsa-miR-4457	82.6498	NM_170782
KCNN3	hsa-miR-6835-3p	82.4758	NM_001204087
KCNN3	hsa-miR-4753-3p	82.2371	NM_001204087
KCNN3	hsa-miR-297	82.177	NM_170782
KCNN3	hsa-miR-27b-3p	82.1738	NM_001204087
KCNN3	hsa-miR-9985	82.1738	NM_001204087
KCNN3	hsa-miR-27a-3p	82.1738	NM_001204087
KCNN3	hsa-miR-8485	82.0894	NM_001204087
KCNN3	hsa-miR-4762-3p	82.0604	NM_001204087
KCNN3	hsa-miR-516b-5p	82.0165	NM_170782
KCNN3	hsa-miR-4770	81.6881	NM_170782
KCNN3	hsa-miR-7151-3p	81.3209	NM_170782
KCNN3	hsa-miR-571	81.1942	NM_170782
KCNN3	hsa-miR-4713-3p	81.0912	NM_001204087
KCNN3	hsa-miR-219a-1-3p	80.9805	NM_170782
KCNN3	hsa-miR-877-3p	80.9041	NM_001204087
KCNN3	hsa-miR-3123	80.5986	NM_170782
KCNN3	hsa-miR-4698	80.424	NM_001204087

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Motifs and transcription factors (TFs) regulating KCNN3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KCNN3	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
KCNN3	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
KCNN3	transfac_pro__M05440	NKX2-3 (directAnnotation).
KCNN3	transfac_pro__M06292	ZNF766 (directAnnotation).
KCNN3	metacluster_161.27	LHX4 (directAnnotation).
KCNN3	tfdimers__MD00602	MYB; STAT6 (directAnnotation).
KCNN3	metacluster_56.4	HSF1; HSF2; HSF2; HSF4 (directAnnotation).
KCNN3	metacluster_161.26	ALX4 (directAnnotation).
KCNN3	metacluster_56.5	HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
KCNN3	metacluster_161.31	PRRX2 (directAnnotation).
KCNN3	metacluster_141.2	E2F2; E2F3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
KCNN3	"Dequalinium"	DB04209	small molecule
KCNN3	"Rimtuzalcap"	DB16733	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."