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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: KCNMA1

Summary for KCNMA1

Gene information	Gene symbol	KCNMA1
	Ensembl ID	ENSG00000156113
	Entrez ID	3778
	Gene name	potassium calcium-activated channel subfamily M alpha 1
	Synonyms	KCa1.1\|mSLO1\|SLO
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KCNMA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.829908	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.97658	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.392068	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.736769	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.530441	5.21e-30
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.707008	1.07e-34
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.379471	3.32e-08
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.516497	1.74e-17
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.900239	0.00e+00

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Expression of KCNMA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KCNMA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KCNMA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KCNMA1	hsa-miR-323a-5p	85.1297	NM_001322837
KCNMA1	hsa-miR-8061	84.923	NM_001322838
KCNMA1	hsa-miR-670-3p	84.8159	NM_001014797
KCNMA1	hsa-miR-3136-3p	84.5012	NM_001322838
KCNMA1	hsa-miR-676-5p	83.7406	NM_001322838
KCNMA1	hsa-miR-5197-3p	83.6665	NM_001014797
KCNMA1	hsa-miR-5683	83.2877	NM_001014797
KCNMA1	hsa-miR-7155-3p	83.1051	NM_001322838
KCNMA1	hsa-miR-6716-5p	83.0253	NM_001014797
KCNMA1	hsa-miR-8089	83.0181	NM_001322837
KCNMA1	hsa-miR-4700-5p	83.0181	NM_001322837
KCNMA1	hsa-miR-4667-5p	83.0181	NM_001322837
KCNMA1	hsa-miR-3529-3p	82.5344	NM_001322837
KCNMA1	hsa-miR-543	82.4052	NM_001014797
KCNMA1	hsa-miR-4639-3p	82.2637	NM_001322838
KCNMA1	hsa-miR-7152-5p	82.1579	NM_001014797
KCNMA1	hsa-miR-218-1-3p	81.9361	NM_001322838
KCNMA1	hsa-let-7c-3p	81.5792	NM_001322838
KCNMA1	hsa-miR-3121-5p	81.5769	NM_001322837
KCNMA1	hsa-miR-5706	81.2434	NM_001322838
KCNMA1	hsa-miR-4782-5p	81.2434	NM_001322838
KCNMA1	hsa-miR-6501-3p	81.0427	NM_001014797
KCNMA1	hsa-miR-153-5p	80.6609	NM_001014797
KCNMA1	hsa-miR-4314	80.6322	NM_001322838
KCNMA1	hsa-miR-4735-5p	80.4643	NM_001322837
KCNMA1	hsa-miR-627-3p	80.1769	NM_001014797

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Motifs and transcription factors (TFs) regulating KCNMA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KCNMA1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
KCNMA1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
KCNMA1	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
KCNMA1	cisbp__M00808	MYPOP (inferredBy_Orthology).
KCNMA1	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
KCNMA1	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
KCNMA1	jaspar__MA1957.1	ELK1 (directAnnotation).
KCNMA1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
KCNMA1	transfac_pro__M07397	ZNF148 (directAnnotation).
KCNMA1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
KCNMA1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
KCNMA1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
KCNMA1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
KCNMA1	transfac_pro__M01175	ZBTB7B (directAnnotation).
KCNMA1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
KCNMA1	tfdimers__MD00151	CHURC1 (directAnnotation).
KCNMA1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
KCNMA1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
KCNMA1	transfac_pro__M01303	SP1 (directAnnotation).
KCNMA1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
KCNMA1	transfac_pro__M02089	E2F3 (directAnnotation).
KCNMA1	metacluster_3.14	WT1; WT1 (directAnnotation).
KCNMA1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
KCNMA1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
KCNMA1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
KCNMA1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
KCNMA1	cisbp__M07938	E2F1 (directAnnotation).
KCNMA1	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
KCNMA1	transfac_pro__M07436	WT1 (directAnnotation).
KCNMA1	transfac_pro__M02281	SP1 (directAnnotation).
KCNMA1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
KCNMA1	transfac_pro__M02898	SMAD3 (directAnnotation).
KCNMA1	transfac_public__M00491	PATZ1 (directAnnotation).
KCNMA1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
KCNMA1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
KCNMA1	jaspar__MA0748.2	YY2 (directAnnotation).
KCNMA1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
KCNMA1	swissregulon__hs__ELK1	ELK1 (directAnnotation).
KCNMA1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
KCNMA1	metacluster_81.7	CREB1 (directAnnotation).
KCNMA1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
KCNMA1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
KCNMA1	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
KCNMA1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
KCNMA1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
KCNMA1	transfac_pro__M04817	ZBTB33 (directAnnotation).
KCNMA1	metacluster_143.13	ZBTB7A (directAnnotation).
KCNMA1	tfdimers__MD00483	ZBTB14 (directAnnotation).
KCNMA1	cisbp__M00968	MTF2 (directAnnotation).
KCNMA1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
KCNMA1	"Bendroflumethiazide"	DB00436	small molecule
KCNMA1	"Chlorzoxazone"	DB00356	small molecule
KCNMA1	"Dequalinium"	DB04209	small molecule
KCNMA1	"Diazoxide"	DB01119	small molecule
KCNMA1	"Halothane"	DB01159	small molecule
KCNMA1	"Hydrochlorothiazide"	DB00999	small molecule
KCNMA1	"Hydroflumethiazide"	DB00774	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."