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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KBTBD8

Summary for KBTBD8

Gene information	Gene symbol	KBTBD8
	Ensembl ID	ENSG00000163376
	Entrez ID	84541
	Gene name	kelch repeat and BTB domain containing 8
	Synonyms	KIAA1842\|TA-KRP
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KBTBD8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.296254	3.81e-16

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Expression of KBTBD8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KBTBD8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KBTBD8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KBTBD8	hsa-miR-4782-3p	88.2342	NM_032505
KBTBD8	hsa-miR-6766-3p	88.2342	NM_032505
KBTBD8	hsa-miR-4671-3p	87.9765	NM_032505
KBTBD8	hsa-miR-550b-2-5p	87.8882	NM_032505
KBTBD8	hsa-miR-26b-5p	87.8831	NM_032505
KBTBD8	hsa-miR-26a-5p	87.8831	NM_032505
KBTBD8	hsa-miR-519b-3p	87.6921	NM_032505
KBTBD8	hsa-miR-519a-3p	87.6921	NM_032505
KBTBD8	hsa-miR-519c-3p	87.6921	NM_032505
KBTBD8	hsa-miR-3124-3p	87.6381	NM_032505
KBTBD8	hsa-miR-4789-5p	87.6152	NM_032505
KBTBD8	hsa-miR-4465	87.5629	NM_032505
KBTBD8	hsa-miR-3152-3p	87.2786	NM_032505
KBTBD8	hsa-miR-4452	86.8122	NM_032505
KBTBD8	hsa-miR-4504	86.7238	NM_032505
KBTBD8	hsa-miR-153-3p	85.6916	NM_032505
KBTBD8	hsa-miR-302e	85.5444	NM_032505
KBTBD8	hsa-miR-548av-3p	84.8617	NM_032505
KBTBD8	hsa-miR-203a-3p	84.6343	NM_032505
KBTBD8	hsa-miR-6124	84.0459	NM_032505
KBTBD8	hsa-miR-337-3p	83.8905	NM_032505
KBTBD8	hsa-miR-3688-3p	83.7519	NM_032505
KBTBD8	hsa-miR-539-3p	83.7107	NM_032505
KBTBD8	hsa-miR-485-3p	83.7107	NM_032505
KBTBD8	hsa-miR-3662	83.5395	NM_032505
KBTBD8	hsa-miR-548g-3p	82.1346	NM_032505
KBTBD8	hsa-miR-33a-3p	82.0982	NM_032505
KBTBD8	hsa-miR-9985	81.1012	NM_032505
KBTBD8	hsa-miR-27b-3p	81.1012	NM_032505
KBTBD8	hsa-miR-27a-3p	81.1012	NM_032505
KBTBD8	hsa-miR-8075	80.8708	NM_032505
KBTBD8	hsa-miR-5579-3p	80.7725	NM_032505
KBTBD8	hsa-miR-6856-3p	80.4894	NM_032505
KBTBD8	hsa-miR-2115-3p	80.4491	NM_032505
KBTBD8	hsa-miR-3927-5p	80.002	NM_032505

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Motifs and transcription factors (TFs) regulating KBTBD8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KBTBD8	metacluster_22.18	BACH2 (inferredBy_Orthology).
KBTBD8	metacluster_22.37	BACH1 (directAnnotation).
KBTBD8	metacluster_22.36	BACH2 (directAnnotation).
KBTBD8	metacluster_22.34	BACH2 (directAnnotation).
KBTBD8	metacluster_22.20	MAFG (directAnnotation).
KBTBD8	metacluster_22.35	MAFK (directAnnotation).
KBTBD8	metacluster_22.16	BACH2 (directAnnotation).
KBTBD8	metacluster_22.13	MAFK (inferredBy_Orthology).
KBTBD8	metacluster_22.33	MAFK (inferredBy_Orthology).
KBTBD8	metacluster_22.32	NFE2L2 (directAnnotation).
KBTBD8	metacluster_22.39	NFE2L2 (directAnnotation).
KBTBD8	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
KBTBD8	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
KBTBD8	metacluster_22.17	NFE2 (directAnnotation).
KBTBD8	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."