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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: KAT2B

Summary for KAT2B

Gene information	Gene symbol	KAT2B
	Ensembl ID	ENSG00000114166
	Entrez ID	8850
	Gene name	lysine acetyltransferase 2B
	Synonyms	GCN5\|GCN5L\|P/CAF\|PCAF
	Gene type	protein_coding
	UniProtAcc	Q92831

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Dataset with differentially expressed gene: KAT2B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.902578	6.89e-03
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.319455	0.00e+00

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Expression of KAT2B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KAT2B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KAT2B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KAT2B	hsa-miR-126-5p	90.3932	NM_003884
KAT2B	hsa-miR-367-3p	90.3635	NM_003884
KAT2B	hsa-miR-25-3p	90.3635	NM_003884
KAT2B	hsa-miR-363-3p	90.3635	NM_003884
KAT2B	hsa-miR-6835-3p	89.8337	NM_003884
KAT2B	hsa-miR-205-5p	89.7332	NM_003884
KAT2B	hsa-miR-9-3p	89.6703	NM_003884
KAT2B	hsa-miR-3160-5p	89.133	NM_003884
KAT2B	hsa-miR-4495	88.5017	NM_003884
KAT2B	hsa-miR-3121-3p	88.2477	NM_003884
KAT2B	hsa-miR-885-5p	87.8322	NM_003884
KAT2B	hsa-miR-4460	87.6101	NM_003884
KAT2B	hsa-miR-7159-3p	87.5697	NM_003884
KAT2B	hsa-miR-335-3p	87.3555	NM_003884
KAT2B	hsa-miR-5696	87.0551	NM_003884
KAT2B	hsa-miR-4423-3p	87.0149	NM_003884
KAT2B	hsa-miR-10399-5p	86.6395	NM_003884
KAT2B	hsa-miR-6504-3p	86.6395	NM_003884
KAT2B	hsa-miR-548t-3p	86.4236	NM_003884
KAT2B	hsa-miR-548ap-3p	86.4236	NM_003884
KAT2B	hsa-miR-548aa	86.4236	NM_003884
KAT2B	hsa-miR-7852-3p	86.3143	NM_003884
KAT2B	hsa-miR-587	86.2274	NM_003884
KAT2B	hsa-miR-5582-5p	86.1018	NM_003884
KAT2B	hsa-miR-758-5p	86.0014	NM_003884
KAT2B	hsa-miR-29a-5p	85.8191	NM_003884
KAT2B	hsa-miR-6718-5p	85.1126	NM_003884
KAT2B	hsa-miR-203b-5p	85.1126	NM_003884
KAT2B	hsa-miR-656-3p	84.7948	NM_003884
KAT2B	hsa-miR-4766-5p	84.3503	NM_003884
KAT2B	hsa-miR-330-3p	83.7035	NM_003884
KAT2B	hsa-miR-497-3p	82.8578	NM_003884
KAT2B	hsa-miR-147b-5p	82.8108	NM_003884
KAT2B	hsa-miR-6832-5p	82.6923	NM_003884
KAT2B	hsa-miR-670-3p	82.1484	NM_003884
KAT2B	hsa-miR-1304-5p	81.6862	NM_003884
KAT2B	hsa-miR-4729	81.6564	NM_003884
KAT2B	hsa-miR-4302	81.6125	NM_003884
KAT2B	hsa-miR-4712-5p	81.5707	NM_003884
KAT2B	hsa-miR-770-5p	81.5707	NM_003884
KAT2B	hsa-miR-4261	81.1333	NM_003884
KAT2B	hsa-miR-3915	80.9075	NM_003884
KAT2B	hsa-miR-27b-3p	80.8567	NM_003884
KAT2B	hsa-miR-27a-3p	80.8567	NM_003884
KAT2B	hsa-miR-9985	80.8567	NM_003884
KAT2B	hsa-miR-5688	80.4677	NM_003884

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Motifs and transcription factors (TFs) regulating KAT2B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KAT2B	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
KAT2B	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
KAT2B	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
KAT2B	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
KAT2B	transfac_pro__M04617	ZBTB7A (directAnnotation).
KAT2B	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
KAT2B	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
KAT2B	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
KAT2B	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
KAT2B	transfac_pro__M07387	ZBTB7A (directAnnotation).
KAT2B	transfac_pro__M07436	WT1 (directAnnotation).
KAT2B	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
KAT2B	transfac_pro__M00716	ZBTB14 (directAnnotation).
KAT2B	swissregulon__hs__CHD1	CHD1 (directAnnotation).
KAT2B	hdpi__HIP2	UBE2K (directAnnotation).
KAT2B	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
KAT2B	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
KAT2B	transfac_pro__M04893	TAF1 (directAnnotation).
KAT2B	transfac_pro__M03876	ZBTB33 (directAnnotation).
KAT2B	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
KAT2B	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
KAT2B	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
KAT2B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
KAT2B	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
KAT2B	hdpi__TP73	TP73 (directAnnotation).
KAT2B	transfac_pro__M04826	EP300 (directAnnotation).
KAT2B	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
KAT2B	hdpi__ETV4	ETV4 (directAnnotation).
KAT2B	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
KAT2B	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
KAT2B	jaspar__MA0748.2	YY2 (directAnnotation).
KAT2B	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
KAT2B	"(3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE"	DB08186	small molecule
KAT2B	"Coenzyme A"	DB01992	small molecule
KAT2B	"N-(3-AMINOPROPYL)-2-NITROBENZENAMINE"	DB08291	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."