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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: JARID2

Summary for JARID2

Gene information	Gene symbol	JARID2
	Ensembl ID	ENSG00000008083
	Entrez ID	3720
	Gene name	jumonji and AT-rich interaction domain containing 2
	Synonyms	JMJ
	Gene type	protein_coding
	UniProtAcc	Q92833

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Dataset with differentially expressed gene: JARID2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.653792	8.34e-43
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.409273	1.13e-39
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.298036	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.337677	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.332535	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-1.18761	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.275095	1.00e-36
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.254851	0.00e+00

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Expression of JARID2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to JARID2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating JARID2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
JARID2	hsa-miR-6838-5p	90.0384	NM_001267040
JARID2	hsa-miR-15b-5p	90.0384	NM_001267040
JARID2	hsa-miR-195-5p	90.0384	NM_001267040
JARID2	hsa-miR-15a-5p	90.0384	NM_001267040
JARID2	hsa-miR-16-5p	89.5621	NM_001267040
JARID2	hsa-miR-4262	89.4399	NM_001267040
JARID2	hsa-miR-6080	89.384	NM_001267040
JARID2	hsa-miR-5011-5p	89.3645	NM_004973
JARID2	hsa-miR-4514	88.7713	NM_001267040
JARID2	hsa-miR-10524-5p	87.935	NM_001267040
JARID2	hsa-miR-5006-3p	87.7382	NM_001267040
JARID2	hsa-miR-4755-5p	87.7382	NM_001267040
JARID2	hsa-miR-6865-3p	87.3846	NM_004973
JARID2	hsa-miR-26a-5p	86.9681	NM_001267040
JARID2	hsa-miR-26b-5p	86.9681	NM_001267040
JARID2	hsa-miR-12129	86.919	NM_001267040
JARID2	hsa-miR-188-5p	86.7535	NM_001267040
JARID2	hsa-miR-6866-3p	86.7535	NM_001267040
JARID2	hsa-miR-8485	86.7506	NM_001267040
JARID2	hsa-miR-181d-5p	86.7284	NM_001267040
JARID2	hsa-miR-181b-5p	86.7284	NM_001267040
JARID2	hsa-miR-181c-5p	86.7284	NM_001267040
JARID2	hsa-miR-181a-5p	86.7284	NM_001267040
JARID2	hsa-miR-7844-5p	86.3396	NM_001267040
JARID2	hsa-miR-548t-3p	85.9573	NM_004973
JARID2	hsa-miR-548ap-3p	85.9573	NM_004973
JARID2	hsa-miR-548aa	85.9573	NM_004973
JARID2	hsa-miR-559	85.8409	NM_004973
JARID2	hsa-miR-935	85.7112	NM_004973
JARID2	hsa-miR-4269	85.5939	NM_001267040
JARID2	hsa-miR-6715b-5p	85.5939	NM_001267040
JARID2	hsa-miR-548ae-5p	85.374	NM_004973
JARID2	hsa-miR-548aq-5p	85.374	NM_004973
JARID2	hsa-miR-548h-5p	85.374	NM_004973
JARID2	hsa-miR-548j-5p	85.374	NM_004973
JARID2	hsa-miR-548c-5p	85.374	NM_004973
JARID2	hsa-miR-548bb-5p	85.374	NM_004973
JARID2	hsa-miR-548a-5p	85.374	NM_004973
JARID2	hsa-miR-548ar-5p	85.374	NM_004973
JARID2	hsa-miR-548b-5p	85.374	NM_004973
JARID2	hsa-miR-548ad-5p	85.374	NM_004973
JARID2	hsa-miR-548as-5p	85.374	NM_004973
JARID2	hsa-miR-548w	85.374	NM_004973
JARID2	hsa-miR-548ak	85.374	NM_004973
JARID2	hsa-miR-548d-5p	85.374	NM_004973
JARID2	hsa-miR-548i	85.374	NM_004973
JARID2	hsa-miR-548ay-5p	85.374	NM_004973
JARID2	hsa-miR-548o-5p	85.374	NM_004973
JARID2	hsa-miR-548ap-5p	85.374	NM_004973
JARID2	hsa-miR-548am-5p	85.374	NM_004973

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Motifs and transcription factors (TFs) regulating JARID2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
JARID2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
JARID2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
JARID2	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
JARID2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
JARID2	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
JARID2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
JARID2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
JARID2	metacluster_3.14	WT1; WT1 (directAnnotation).
JARID2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
JARID2	cisbp__M07938	E2F1 (directAnnotation).
JARID2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
JARID2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
JARID2	transfac_pro__M04950	EGR1 (directAnnotation).
JARID2	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
JARID2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
JARID2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
JARID2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
JARID2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
JARID2	transfac_pro__M00652	NRF1 (directAnnotation).
JARID2	transfac_pro__M04866	HDAC2 (directAnnotation).
JARID2	jaspar__MA1122.1	TFDP1 (directAnnotation).
JARID2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
JARID2	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
JARID2	cisbp__M01815	CEBPE (inferredBy_Orthology).
JARID2	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
JARID2	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
JARID2	jaspar__MA1125.1	ZNF384 (directAnnotation).
JARID2	kznf__CTCF_Rhee2011.2_ChIP-exo	CTCF (directAnnotation).
JARID2	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
JARID2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
JARID2	transfac_pro__M01253	CNOT3 (directAnnotation).
JARID2	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
JARID2	transfac_pro__M02089	E2F3 (directAnnotation).
JARID2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
JARID2	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
JARID2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
JARID2	transfac_pro__M04916	TAF1 (directAnnotation).
JARID2	transfac_pro__M12697	ZNF142 (directAnnotation).
JARID2	metacluster_111.5	E4F1; E4F1 (directAnnotation).
JARID2	transfac_pro__M06408	ZSCAN30 (directAnnotation).
JARID2	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
JARID2	cisbp__M00788	ZFY (inferredBy_Orthology).
JARID2	metacluster_7.13	ZFX (directAnnotation).
JARID2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
JARID2	hdpi__HIP2	UBE2K (directAnnotation).
JARID2	transfac_pro__M02913	SP140 (inferredBy_Orthology).
JARID2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
JARID2	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
JARID2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
JARID2	transfac_pro__M02898	SMAD3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."