Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: JADE1

Summary for JADE1

Gene information	Gene symbol	JADE1
	Ensembl ID	ENSG00000077684
	Entrez ID	79960
	Gene name	jade family PHD finger 1
	Synonyms	JADE-1\|PHF17
	Gene type	protein_coding
	UniProtAcc	Q6IE81

Top

Dataset with differentially expressed gene: JADE1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.411193	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.294317	0.00e+00

Top

Expression of JADE1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to JADE1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating JADE1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
JADE1	hsa-miR-580-5p	88.5047	NM_001287439
JADE1	hsa-miR-1910-5p	88.1868	NM_001287437
JADE1	hsa-miR-4671-3p	88.0728	NM_001287437
JADE1	hsa-miR-1305	88.0542	NM_001287439
JADE1	hsa-miR-451b	88.0135	NM_001287437
JADE1	hsa-miR-6882-3p	87.8663	NM_001287439
JADE1	hsa-miR-1229-3p	87.722	NM_001287437
JADE1	hsa-miR-153-5p	87.7199	NM_001287439
JADE1	hsa-miR-7-5p	87.6579	NM_001287437
JADE1	hsa-miR-3182	87.5025	NM_001287441
JADE1	hsa-miR-155-5p	87.4189	NM_001287439
JADE1	hsa-miR-335-3p	87.0869	NM_001287441
JADE1	hsa-miR-4776-3p	86.7833	NM_001287437
JADE1	hsa-miR-4427	86.7282	NM_001287439
JADE1	hsa-miR-548as-3p	86.5168	NM_001287439
JADE1	hsa-miR-6079	86.4733	NM_001287439
JADE1	hsa-miR-4522	86.4379	NM_001287439
JADE1	hsa-miR-219b-3p	86.2166	NM_001287439
JADE1	hsa-miR-3171	86.1115	NM_001287439
JADE1	hsa-miR-568	86.0028	NM_001287437
JADE1	hsa-miR-122b-5p	85.9845	NM_001287437
JADE1	hsa-miR-890	85.8709	NM_001287439
JADE1	hsa-miR-10393-5p	85.813	NM_001287437
JADE1	hsa-miR-500a-3p	85.6795	NM_001287437
JADE1	hsa-miR-3188	85.5102	NM_001287439
JADE1	hsa-miR-4673	85.3865	NM_001287439
JADE1	hsa-miR-32-3p	85.275	NM_001287437
JADE1	hsa-miR-548an	85.192	NM_001287437
JADE1	hsa-miR-4741	85.1002	NM_001287437
JADE1	hsa-miR-4675	85.1002	NM_001287437
JADE1	hsa-miR-1915-5p	85.0298	NM_001287437
JADE1	hsa-miR-3177-5p	84.9645	NM_001287441
JADE1	hsa-miR-7977	84.6716	NM_001287439
JADE1	hsa-miR-153-3p	84.6614	NM_001287437
JADE1	hsa-miR-3137	84.6452	NM_001287441
JADE1	hsa-miR-509-3p	84.4212	NM_001287441
JADE1	hsa-miR-3124-3p	84.2752	NM_001287437
JADE1	hsa-miR-6885-3p	83.8875	NM_001287437
JADE1	hsa-miR-3163	83.7506	NM_001287439
JADE1	hsa-miR-3910	83.6248	NM_001287437
JADE1	hsa-miR-4645-5p	83.4457	NM_001287439
JADE1	hsa-miR-502-3p	83.3248	NM_001287437
JADE1	hsa-miR-501-3p	83.3248	NM_001287437
JADE1	hsa-miR-218-5p	83.2517	NM_001287437
JADE1	hsa-miR-19a-3p	83.0638	NM_001287437
JADE1	hsa-miR-19b-3p	83.0638	NM_001287437
JADE1	hsa-miR-7159-3p	83.0512	NM_001287437
JADE1	hsa-miR-499a-5p	82.9831	NM_001287437
JADE1	hsa-miR-6796-5p	82.6246	NM_001287439
JADE1	hsa-miR-581	81.9879	NM_001287439

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating JADE1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
JADE1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
JADE1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
JADE1	transfac_pro__M07397	ZNF148 (directAnnotation).
JADE1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
JADE1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
JADE1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
JADE1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
JADE1	metacluster_7.13	ZFX (directAnnotation).
JADE1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
JADE1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
JADE1	transfac_pro__M01175	ZBTB7B (directAnnotation).
JADE1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
JADE1	tfdimers__MD00151	CHURC1 (directAnnotation).
JADE1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
JADE1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
JADE1	transfac_pro__M01303	SP1 (directAnnotation).
JADE1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
JADE1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
JADE1	transfac_pro__M02090	E2F4 (directAnnotation).
JADE1	transfac_pro__M01714	KLF15 (directAnnotation).
JADE1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
JADE1	jaspar__MA1122.1	TFDP1 (directAnnotation).
JADE1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
JADE1	transfac_pro__M02089	E2F3 (directAnnotation).
JADE1	transfac_pro__M12604	ZNF444 (directAnnotation).
JADE1	metacluster_3.14	WT1; WT1 (directAnnotation).
JADE1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
JADE1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
JADE1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
JADE1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
JADE1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
JADE1	cisbp__M07938	E2F1 (directAnnotation).
JADE1	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
JADE1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
JADE1	transfac_pro__M07436	WT1 (directAnnotation).
JADE1	transfac_pro__M02281	SP1 (directAnnotation).
JADE1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
JADE1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
JADE1	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
JADE1	transfac_pro__M02898	SMAD3 (directAnnotation).
JADE1	transfac_public__M00491	PATZ1 (directAnnotation).
JADE1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
JADE1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
JADE1	jaspar__MA0748.2	YY2 (directAnnotation).
JADE1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
JADE1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
JADE1	cisbp__M00788	ZFY (inferredBy_Orthology).
JADE1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
JADE1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
JADE1	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."