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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ITPRIPL2

Summary for ITPRIPL2

Gene information	Gene symbol	ITPRIPL2
	Ensembl ID	ENSG00000205730
	Entrez ID	162073
	Gene name	ITPRIP like 2
	Synonyms	FLJ22994\|LOC162073\|MGC126798\|MGC126800
	Gene type	protein_coding
	UniProtAcc	Q3MIP1

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Dataset with differentially expressed gene: ITPRIPL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.285718	3.96e-20
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.458531	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.401403	6.65e-37

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Expression of ITPRIPL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ITPRIPL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ITPRIPL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ITPRIPL2	hsa-miR-1180-5p	87.2162	NM_001034841
ITPRIPL2	hsa-miR-3121-3p	86.8995	NM_001034841
ITPRIPL2	hsa-miR-4666a-5p	86.8479	NM_001034841
ITPRIPL2	hsa-miR-19b-1-5p	86.6158	NM_001034841
ITPRIPL2	hsa-miR-19a-5p	86.6158	NM_001034841
ITPRIPL2	hsa-miR-19b-2-5p	86.6158	NM_001034841
ITPRIPL2	hsa-miR-1468-3p	85.7693	NM_001034841
ITPRIPL2	hsa-miR-6843-3p	85.6366	NM_001034841
ITPRIPL2	hsa-miR-6848-3p	85.6366	NM_001034841
ITPRIPL2	hsa-miR-302e	84.693	NM_001034841
ITPRIPL2	hsa-miR-520h	84.3137	NM_001034841
ITPRIPL2	hsa-miR-520g-3p	84.3137	NM_001034841
ITPRIPL2	hsa-miR-4724-5p	83.6068	NM_001034841
ITPRIPL2	hsa-miR-493-5p	83.2735	NM_001034841
ITPRIPL2	hsa-miR-141-3p	82.6874	NM_001034841
ITPRIPL2	hsa-miR-200a-3p	82.6874	NM_001034841
ITPRIPL2	hsa-miR-216b-5p	82.0626	NM_001034841
ITPRIPL2	hsa-miR-6769a-3p	81.8051	NM_001034841
ITPRIPL2	hsa-miR-4796-3p	81.6261	NM_001034841
ITPRIPL2	hsa-miR-3180-5p	81.5986	NM_001034841
ITPRIPL2	hsa-miR-32-3p	81.3613	NM_001034841
ITPRIPL2	hsa-miR-5685	81.2946	NM_001034841
ITPRIPL2	hsa-miR-4690-3p	81.2946	NM_001034841
ITPRIPL2	hsa-miR-766-3p	80.9885	NM_001034841
ITPRIPL2	hsa-miR-302a-3p	80.64	NM_001034841
ITPRIPL2	hsa-miR-520a-3p	80.64	NM_001034841
ITPRIPL2	hsa-miR-302b-3p	80.64	NM_001034841
ITPRIPL2	hsa-miR-302d-3p	80.64	NM_001034841
ITPRIPL2	hsa-miR-520d-3p	80.64	NM_001034841
ITPRIPL2	hsa-miR-373-3p	80.64	NM_001034841
ITPRIPL2	hsa-miR-520e-3p	80.64	NM_001034841
ITPRIPL2	hsa-miR-520b-3p	80.64	NM_001034841
ITPRIPL2	hsa-miR-372-3p	80.64	NM_001034841
ITPRIPL2	hsa-miR-520c-3p	80.64	NM_001034841
ITPRIPL2	hsa-miR-302c-3p	80.64	NM_001034841
ITPRIPL2	hsa-miR-765	80.6321	NM_001034841
ITPRIPL2	hsa-miR-3680-3p	80.2068	NM_001034841

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Motifs and transcription factors (TFs) regulating ITPRIPL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ITPRIPL2	transfac_pro__M06213	ZNF267 (directAnnotation).
ITPRIPL2	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
ITPRIPL2	metacluster_52.11	ZNF184 (directAnnotation).
ITPRIPL2	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
ITPRIPL2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ITPRIPL2	metacluster_7.13	ZFX (directAnnotation).
ITPRIPL2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ITPRIPL2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ITPRIPL2	cisbp__M00341	PAX6 (directAnnotation).
ITPRIPL2	metacluster_198.3	ZFP64 (directAnnotation).
ITPRIPL2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ITPRIPL2	cisbp__M00788	ZFY (inferredBy_Orthology).
ITPRIPL2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ITPRIPL2	transfac_pro__M01199	TRIM28 (directAnnotation).
ITPRIPL2	metacluster_151.2	ZNF23 (directAnnotation).
ITPRIPL2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ITPRIPL2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."