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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: IRS1

Summary for IRS1

Gene information	Gene symbol	IRS1
	Ensembl ID	ENSG00000169047
	Entrez ID	3667
	Gene name	insulin receptor substrate 1
	Synonyms	HIRS-1
	Gene type	protein_coding
	UniProtAcc	P35568

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Dataset with differentially expressed gene: IRS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.502875	0.00e+00

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Expression of IRS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IRS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
IRS1	Epigenetic Alteration of DNA, RNA or Protein
IRS1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating IRS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IRS1	hsa-miR-4729	85.7655	NM_005544
IRS1	hsa-miR-4328	85.6379	NM_005544
IRS1	hsa-miR-3928-3p	85.2794	NM_005544
IRS1	hsa-miR-183-5p	85.1565	NM_005544
IRS1	hsa-miR-3613-3p	85.0754	NM_005544
IRS1	hsa-miR-1245b-3p	85.0663	NM_005544
IRS1	hsa-miR-1323	84.9391	NM_005544
IRS1	hsa-miR-6124	84.9136	NM_005544
IRS1	hsa-miR-12120	84.773	NM_005544
IRS1	hsa-miR-1200	84.6568	NM_005544
IRS1	hsa-miR-4666a-3p	84.0296	NM_005544
IRS1	hsa-miR-550a-3p	83.9964	NM_005544
IRS1	hsa-miR-4680-3p	83.7657	NM_005544
IRS1	hsa-miR-7152-5p	83.6287	NM_005544
IRS1	hsa-miR-7162-3p	82.2783	NM_005544
IRS1	hsa-miR-548o-3p	81.9027	NM_005544
IRS1	hsa-miR-302b-5p	81.1386	NM_005544
IRS1	hsa-miR-302d-5p	81.1386	NM_005544
IRS1	hsa-miR-3133	80.8773	NM_005544
IRS1	hsa-miR-6759-3p	80.7799	NM_005544
IRS1	hsa-miR-2115-5p	80.5747	NM_005544
IRS1	hsa-miR-32-3p	80.5306	NM_005544
IRS1	hsa-miR-7856-5p	80.3474	NM_005544
IRS1	hsa-miR-559	80.1043	NM_005544

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Motifs and transcription factors (TFs) regulating IRS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IRS1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
IRS1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
IRS1	hdpi__TP73	TP73 (directAnnotation).
IRS1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
IRS1	cisbp__M02645	ETS1 (directAnnotation).
IRS1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
IRS1	transfac_pro__M06305	ZNF583 (inferredBy_Orthology).
IRS1	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
IRS1	hdpi__ETV4	ETV4 (directAnnotation).
IRS1	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
IRS1	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
IRS1	taipale_tf_pairs__MYBL1_EOMES_NNSYGNCNAACNNNNNNCACRCNN_CAP_repr	EOMES; MYBL1 (directAnnotation).
IRS1	taipale_tf_pairs__POU2F1_ETV1_NCCGGATATGCAN_CAP_repr	ETV1; POU2F1 (directAnnotation).
IRS1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
IRS1	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
IRS1	"[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID"	DB08513	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."