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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: IPMK

Summary for IPMK

Gene information	Gene symbol	IPMK
	Ensembl ID	ENSG00000151151
	Entrez ID	253430
	Gene name	inositol polyphosphate multikinase
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q8NFU5

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Dataset with differentially expressed gene: IPMK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.342071	0.00e+00

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Expression of IPMK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IPMK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating IPMK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IPMK	hsa-miR-544b	88.9005	NM_152230
IPMK	hsa-miR-5692b	88.5392	NM_152230
IPMK	hsa-miR-5692c	88.5392	NM_152230
IPMK	hsa-miR-548c-3p	88.0319	NM_152230
IPMK	hsa-miR-374c-5p	87.9322	NM_152230
IPMK	hsa-miR-655-3p	87.9322	NM_152230
IPMK	hsa-miR-5692a	87.7524	NM_152230
IPMK	hsa-miR-8080	87.7322	NM_152230
IPMK	hsa-miR-616-5p	86.7259	NM_152230
IPMK	hsa-miR-371b-5p	86.7259	NM_152230
IPMK	hsa-miR-373-5p	86.7259	NM_152230
IPMK	hsa-miR-670-5p	86.4207	NM_152230
IPMK	hsa-miR-4263	86.2999	NM_152230
IPMK	hsa-miR-513a-5p	85.8373	NM_152230
IPMK	hsa-miR-376a-2-5p	84.9836	NM_152230
IPMK	hsa-miR-3138	84.9796	NM_152230
IPMK	hsa-miR-376c-3p	84.7903	NM_152230
IPMK	hsa-miR-4438	84.7234	NM_152230
IPMK	hsa-miR-548aj-3p	84.7109	NM_152230
IPMK	hsa-miR-548x-3p	84.7109	NM_152230
IPMK	hsa-miR-7-1-3p	84.6321	NM_152230
IPMK	hsa-miR-7-2-3p	84.6321	NM_152230
IPMK	hsa-let-7f-1-3p	84.5139	NM_152230
IPMK	hsa-let-7b-3p	84.5139	NM_152230
IPMK	hsa-miR-98-3p	84.5139	NM_152230
IPMK	hsa-let-7a-3p	84.5139	NM_152230
IPMK	hsa-miR-664a-3p	84.3708	NM_152230
IPMK	hsa-miR-548ah-3p	83.8993	NM_152230
IPMK	hsa-miR-548ae-3p	83.8993	NM_152230
IPMK	hsa-miR-548j-3p	83.8993	NM_152230
IPMK	hsa-miR-548aq-3p	83.8993	NM_152230
IPMK	hsa-miR-548am-3p	83.8993	NM_152230
IPMK	hsa-miR-4804-3p	83.6146	NM_152230
IPMK	hsa-miR-1303	83.2087	NM_152230
IPMK	hsa-miR-12136	83.1975	NM_152230
IPMK	hsa-miR-1297	82.8927	NM_152230
IPMK	hsa-miR-610	82.8686	NM_152230
IPMK	hsa-miR-1298-5p	82.6643	NM_152230
IPMK	hsa-miR-1912-5p	82.5035	NM_152230
IPMK	hsa-miR-6871-3p	82.0044	NM_152230
IPMK	hsa-miR-142-3p	81.9708	NM_152230
IPMK	hsa-miR-4799-5p	81.8005	NM_152230
IPMK	hsa-miR-587	81.663	NM_152230
IPMK	hsa-miR-6875-3p	81.5586	NM_152230
IPMK	hsa-miR-6807-5p	81.5411	NM_152230
IPMK	hsa-miR-345-3p	81.29	NM_152230
IPMK	hsa-miR-577	81.2281	NM_152230
IPMK	hsa-miR-4495	81.2279	NM_152230
IPMK	hsa-miR-770-5p	80.9455	NM_152230
IPMK	hsa-miR-4712-5p	80.9455	NM_152230

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Motifs and transcription factors (TFs) regulating IPMK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IPMK	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
IPMK	metacluster_160.20	JUND; PRDM15 (directAnnotation).
IPMK	metacluster_154.2	PAX1; PAX2; PAX2; PAX2; PAX2; PAX4; PAX4; PAX4; PAX4; PAX4; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX8; PAX8; PAX9 (directAnnotation). PAX1; PAX1; PAX1; PAX5; PAX6; PAX6 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."