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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: HDAC9

Summary for HDAC9

Gene information	Gene symbol	HDAC9
	Ensembl ID	ENSG00000048052
	Entrez ID	9734
	Gene name	histone deacetylase 9
	Synonyms	HD7\|HDAC\|HDAC7B\|KIAA0744\|MITR
	Gene type	protein_coding
	UniProtAcc	Q9UKV0

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Dataset with differentially expressed gene: HDAC9

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.45658	6.27e-03

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Expression of HDAC9 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HDAC9

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HDAC9

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HDAC9	hsa-miR-499a-5p	89.1386	NM_178425
HDAC9	hsa-miR-6529-5p	88.8494	NM_001321869
HDAC9	hsa-miR-3119	88.5403	NM_001321877
HDAC9	hsa-miR-1277-5p	87.9287	NM_178425
HDAC9	hsa-miR-12122	87.802	NM_001321869
HDAC9	hsa-miR-4477b	87.722	NM_178425
HDAC9	hsa-miR-5009-5p	87.4209	NM_178425
HDAC9	hsa-miR-548ao-5p	87.391	NM_001321869
HDAC9	hsa-miR-548ax	87.391	NM_001321869
HDAC9	hsa-miR-4786-5p	87.3588	NM_178425
HDAC9	hsa-miR-372-5p	87.1414	NM_001321869
HDAC9	hsa-miR-580-3p	87.002	NM_178425
HDAC9	hsa-miR-6077	86.9611	NM_001321869
HDAC9	hsa-miR-500b-3p	86.9034	NM_001321877
HDAC9	hsa-miR-8081	86.8334	NM_001321877
HDAC9	hsa-miR-7161-5p	86.5278	NM_001321876
HDAC9	hsa-miR-3942-3p	86.5097	NM_178425
HDAC9	hsa-miR-3976	86.4858	NM_001321869
HDAC9	hsa-miR-548u	86.1462	NM_001321876
HDAC9	hsa-miR-494-3p	85.9278	NM_001321869
HDAC9	hsa-miR-4326	85.8417	NM_001321876
HDAC9	hsa-miR-9983-3p	85.766	NM_001321869
HDAC9	hsa-miR-29b-1-5p	85.6631	NM_178425
HDAC9	hsa-miR-6730-5p	85.4792	NM_178425
HDAC9	hsa-miR-3125	85.4252	NM_178425
HDAC9	hsa-miR-4261	85.0671	NM_178425
HDAC9	hsa-miR-559	85.0042	NM_001321869
HDAC9	hsa-miR-664b-3p	84.9249	NM_001321877
HDAC9	hsa-miR-579-3p	84.9249	NM_001321877
HDAC9	hsa-miR-548au-5p	84.7512	NM_001321869
HDAC9	hsa-miR-548ae-5p	84.7512	NM_001321869
HDAC9	hsa-miR-548j-5p	84.7512	NM_001321869
HDAC9	hsa-miR-548i	84.7512	NM_001321869
HDAC9	hsa-miR-548o-5p	84.7512	NM_001321869
HDAC9	hsa-miR-548ab	84.7512	NM_001321869
HDAC9	hsa-miR-548aq-5p	84.7512	NM_001321869
HDAC9	hsa-miR-548w	84.7512	NM_001321869
HDAC9	hsa-miR-548am-5p	84.7512	NM_001321869
HDAC9	hsa-miR-548ak	84.7512	NM_001321869
HDAC9	hsa-miR-548ad-5p	84.7512	NM_001321869
HDAC9	hsa-miR-548ay-5p	84.7512	NM_001321869
HDAC9	hsa-miR-548bb-5p	84.7512	NM_001321869
HDAC9	hsa-miR-548b-5p	84.7512	NM_001321869
HDAC9	hsa-miR-548y	84.7512	NM_001321869
HDAC9	hsa-miR-548a-5p	84.7512	NM_001321869
HDAC9	hsa-miR-548ap-5p	84.7512	NM_001321869
HDAC9	hsa-miR-548d-5p	84.7512	NM_001321869
HDAC9	hsa-miR-548c-5p	84.7512	NM_001321869
HDAC9	hsa-miR-548as-5p	84.7512	NM_001321869
HDAC9	hsa-miR-548h-5p	84.7512	NM_001321869

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Motifs and transcription factors (TFs) regulating HDAC9

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HDAC9	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
HDAC9	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
HDAC9	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
HDAC9	transfac_pro__M04617	ZBTB7A (directAnnotation).
HDAC9	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
HDAC9	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
HDAC9	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
HDAC9	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
HDAC9	transfac_pro__M07387	ZBTB7A (directAnnotation).
HDAC9	transfac_pro__M07436	WT1 (directAnnotation).
HDAC9	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
HDAC9	transfac_pro__M00716	ZBTB14 (directAnnotation).
HDAC9	swissregulon__hs__CHD1	CHD1 (directAnnotation).
HDAC9	hdpi__HIP2	UBE2K (directAnnotation).
HDAC9	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
HDAC9	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
HDAC9	transfac_pro__M04893	TAF1 (directAnnotation).
HDAC9	transfac_pro__M03876	ZBTB33 (directAnnotation).
HDAC9	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
HDAC9	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
HDAC9	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
HDAC9	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
HDAC9	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
HDAC9	"Valproic acid"	DB00313	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."