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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GPC6

Summary for GPC6

Gene information	Gene symbol	GPC6
	Ensembl ID	ENSG00000183098
	Entrez ID	10082
	Gene name	glypican 6
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9Y625

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Dataset with differentially expressed gene: GPC6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.533774	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.306139	0.00e+00

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Expression of GPC6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GPC6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GPC6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GPC6	hsa-miR-524-5p	91.7402	NM_005708
GPC6	hsa-miR-4728-3p	91.7087	NM_005708
GPC6	hsa-miR-6817-3p	91.6033	NM_005708
GPC6	hsa-miR-3153	91.2085	NM_005708
GPC6	hsa-miR-3129-3p	90.6762	NM_005708
GPC6	hsa-miR-5583-5p	90.6762	NM_005708
GPC6	hsa-miR-431-5p	90.6315	NM_005708
GPC6	hsa-miR-23b-5p	90.6036	NM_005708
GPC6	hsa-miR-5197-5p	90.3797	NM_005708
GPC6	hsa-miR-3973	90.1542	NM_005708
GPC6	hsa-miR-6885-3p	89.9353	NM_005708
GPC6	hsa-miR-9903	89.9041	NM_005708
GPC6	hsa-miR-4470	89.7827	NM_005708
GPC6	hsa-miR-942-5p	89.6961	NM_005708
GPC6	hsa-miR-4645-3p	89.413	NM_005708
GPC6	hsa-miR-6739-5p	89.3447	NM_005708
GPC6	hsa-miR-6733-5p	89.3447	NM_005708
GPC6	hsa-miR-1305	89.1126	NM_005708
GPC6	hsa-miR-548c-3p	88.6264	NM_005708
GPC6	hsa-miR-6728-3p	88.5561	NM_005708
GPC6	hsa-miR-887-5p	88.4699	NM_005708
GPC6	hsa-miR-6866-3p	88.4062	NM_005708
GPC6	hsa-miR-188-5p	88.4062	NM_005708
GPC6	hsa-miR-629-3p	88.347	NM_005708
GPC6	hsa-miR-124-5p	88.1712	NM_005708
GPC6	hsa-miR-517-5p	88.0281	NM_005708
GPC6	hsa-miR-3671	87.9767	NM_005708
GPC6	hsa-miR-1252-5p	87.6967	NM_005708
GPC6	hsa-miR-23a-5p	87.5849	NM_005708
GPC6	hsa-miR-1251-3p	87.5181	NM_005708
GPC6	hsa-miR-4694-3p	87.4194	NM_005708
GPC6	hsa-miR-3085-5p	87.0516	NM_005708
GPC6	hsa-miR-4328	87.0485	NM_005708
GPC6	hsa-miR-3913-5p	86.4414	NM_005708
GPC6	hsa-miR-6513-5p	86.4414	NM_005708
GPC6	hsa-miR-6080	86.2567	NM_005708
GPC6	hsa-miR-4666a-3p	86.2462	NM_005708
GPC6	hsa-miR-559	86.1741	NM_005708
GPC6	hsa-miR-548bb-3p	85.8891	NM_005708
GPC6	hsa-miR-548h-3p	85.8891	NM_005708
GPC6	hsa-miR-548z	85.8891	NM_005708
GPC6	hsa-miR-548d-3p	85.8891	NM_005708
GPC6	hsa-miR-548ac	85.8891	NM_005708
GPC6	hsa-miR-365b-3p	85.192	NM_005708
GPC6	hsa-miR-365a-3p	85.192	NM_005708
GPC6	hsa-miR-4282	85.1192	NM_005708
GPC6	hsa-miR-4424	84.8332	NM_005708
GPC6	hsa-miR-7156-5p	84.4411	NM_005708
GPC6	hsa-miR-548a-5p	84.123	NM_005708
GPC6	hsa-miR-548as-5p	84.123	NM_005708

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Motifs and transcription factors (TFs) regulating GPC6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GPC6	metacluster_7.13	ZFX (directAnnotation).
GPC6	cisbp__M01863	ZNF711 (inferredBy_Orthology).
GPC6	metacluster_151.2	ZNF23 (directAnnotation).
GPC6	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
GPC6	transfac_pro__M05479	ZNF580 (directAnnotation).
GPC6	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
GPC6	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
GPC6	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
GPC6	hdpi__ETV4	ETV4 (directAnnotation).
GPC6	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
GPC6	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
GPC6	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
GPC6	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
GPC6	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
GPC6	transfac_pro__M04950	EGR1 (directAnnotation).
GPC6	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
GPC6	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
GPC6	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
GPC6	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
GPC6	transfac_pro__M00652	NRF1 (directAnnotation).
GPC6	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
GPC6	transfac_pro__M04866	HDAC2 (directAnnotation).
GPC6	jaspar__MA1122.1	TFDP1 (directAnnotation).
GPC6	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
GPC6	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."