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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GPATCH2L

Summary for GPATCH2L

Gene information	Gene symbol	GPATCH2L
	Ensembl ID	ENSG00000089916
	Entrez ID	55668
	Gene name	G-patch domain containing 2 like
	Synonyms	C14orf118\|FLJ10033\|FLJ20689
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: GPATCH2L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.324739	4.60e-33

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Expression of GPATCH2L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GPATCH2L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GPATCH2L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GPATCH2L	hsa-miR-3662	90.3721	NM_017926
GPATCH2L	hsa-miR-629-5p	90.2671	NM_001322030
GPATCH2L	hsa-miR-4434	90.1985	NM_001322030
GPATCH2L	hsa-miR-5703	90.1985	NM_001322030
GPATCH2L	hsa-miR-4516	89.9982	NM_001322030
GPATCH2L	hsa-miR-544a	89.84	NM_017926
GPATCH2L	hsa-miR-4775	89.8239	NM_001322030
GPATCH2L	hsa-miR-12131	89.4503	NM_001322030
GPATCH2L	hsa-miR-942-3p	89.2473	NM_001322030
GPATCH2L	hsa-miR-6765-3p	89.0288	NM_001322029
GPATCH2L	hsa-miR-15a-3p	88.9674	NM_001322031
GPATCH2L	hsa-miR-4645-5p	88.863	NM_001322027
GPATCH2L	hsa-miR-589-3p	88.7088	NM_017926
GPATCH2L	hsa-miR-4496	88.5485	NM_017926
GPATCH2L	hsa-miR-8054	88.4693	NM_001322026
GPATCH2L	hsa-miR-548k	88.4693	NM_001322026
GPATCH2L	hsa-miR-548av-5p	88.4693	NM_001322026
GPATCH2L	hsa-miR-4768-5p	88.42	NM_017926
GPATCH2L	hsa-miR-1178-5p	88.3528	NM_001322027
GPATCH2L	hsa-miR-3133	88.0588	NM_001322031
GPATCH2L	hsa-miR-3613-3p	87.6131	NM_001322027
GPATCH2L	hsa-miR-892b	87.4762	NM_001322031
GPATCH2L	hsa-miR-4530	87.1778	NM_017926
GPATCH2L	hsa-miR-1275	87.1344	NM_001322031
GPATCH2L	hsa-miR-188-5p	87.091	NM_001322027
GPATCH2L	hsa-miR-6866-3p	87.091	NM_001322027
GPATCH2L	hsa-miR-589-5p	87.0892	NM_017926
GPATCH2L	hsa-miR-676-5p	87.0326	NM_017926
GPATCH2L	hsa-miR-95-5p	86.9959	NM_001322027
GPATCH2L	hsa-miR-6759-3p	86.9807	NM_017926
GPATCH2L	hsa-miR-455-3p	86.9277	NM_017926
GPATCH2L	hsa-miR-140-3p	86.8435	NM_001322031
GPATCH2L	hsa-miR-5582-3p	86.6757	NM_001322030
GPATCH2L	hsa-miR-508-5p	86.4178	NM_001322031
GPATCH2L	hsa-miR-874-5p	86.3974	NM_017926
GPATCH2L	hsa-miR-6768-5p	86.3806	NM_017926
GPATCH2L	hsa-miR-4723-3p	86.1949	NM_001322032
GPATCH2L	hsa-miR-3183	86.1949	NM_001322032
GPATCH2L	hsa-miR-6769b-3p	86.1949	NM_001322032
GPATCH2L	hsa-miR-582-3p	86.0293	NM_017926
GPATCH2L	hsa-miR-5699-5p	85.9942	NM_017926
GPATCH2L	hsa-miR-642b-5p	85.6757	NM_001322031
GPATCH2L	hsa-miR-1283	85.5987	NM_001322026
GPATCH2L	hsa-miR-873-5p	85.5102	NM_017926
GPATCH2L	hsa-miR-6876-5p	85.4211	NM_001322027
GPATCH2L	hsa-miR-4476	85.4211	NM_001322027
GPATCH2L	hsa-miR-6840-3p	85.3406	NM_001322027
GPATCH2L	hsa-miR-410-3p	85.3111	NM_001322031
GPATCH2L	hsa-miR-196b-5p	85.2456	NM_001322031
GPATCH2L	hsa-miR-196a-5p	85.2456	NM_001322031

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Motifs and transcription factors (TFs) regulating GPATCH2L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GPATCH2L	metacluster_7.13	ZFX (directAnnotation).
GPATCH2L	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
GPATCH2L	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
GPATCH2L	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
GPATCH2L	cisbp__M00788	ZFY (inferredBy_Orthology).
GPATCH2L	metacluster_175.1	ZNF283 (directAnnotation).
GPATCH2L	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
GPATCH2L	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
GPATCH2L	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
GPATCH2L	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
GPATCH2L	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."