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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GOPC

Summary for GOPC

Gene information	Gene symbol	GOPC
	Ensembl ID	ENSG00000047932
	Entrez ID	57120
	Gene name	golgi associated PDZ and coiled-coil motif containing
	Synonyms	CAL\|dJ94G16.2\|FIG\|GOPC1\|PIST
	Gene type	protein_coding
	UniProtAcc	Q9HD26

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Dataset with differentially expressed gene: GOPC

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.306585	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.297873	1.01e-20
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.31928	0.00e+00

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Expression of GOPC in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GOPC

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GOPC

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GOPC	hsa-miR-1277-5p	87.4612	NM_001017408
GOPC	hsa-miR-4429	87.4449	NM_020399
GOPC	hsa-miR-320d	87.4449	NM_020399
GOPC	hsa-miR-320b	87.4449	NM_020399
GOPC	hsa-miR-320a-3p	87.4449	NM_020399
GOPC	hsa-miR-320c	87.4449	NM_020399
GOPC	hsa-miR-3124-3p	87.4352	NM_020399
GOPC	hsa-miR-491-3p	87.3847	NM_020399
GOPC	hsa-miR-551b-5p	87.2791	NM_001017408
GOPC	hsa-miR-548p	87.1688	NM_020399
GOPC	hsa-miR-9902	86.4072	NM_020399
GOPC	hsa-miR-4786-3p	85.7667	NM_001017408
GOPC	hsa-miR-211-3p	85.7251	NM_020399
GOPC	hsa-miR-4463	85.2852	NM_020399
GOPC	hsa-miR-10524-5p	85.1677	NM_020399
GOPC	hsa-miR-576-5p	84.5234	NM_001017408
GOPC	hsa-miR-4263	84.5234	NM_001017408
GOPC	hsa-miR-570-3p	84.1062	NM_020399
GOPC	hsa-miR-4261	83.024	NM_020399
GOPC	hsa-miR-5699-5p	82.6591	NM_020399
GOPC	hsa-miR-935	82.4923	NM_020399
GOPC	hsa-miR-1910-5p	82.2538	NM_020399
GOPC	hsa-miR-4698	82.0448	NM_020399
GOPC	hsa-miR-33a-3p	81.843	NM_020399
GOPC	hsa-miR-12127	81.8177	NM_020399
GOPC	hsa-miR-651-3p	81.3759	NM_001017408
GOPC	hsa-miR-1231	81.1483	NM_020399
GOPC	hsa-miR-6830-5p	80.9251	NM_001017408
GOPC	hsa-miR-335-5p	80.6114	NM_001017408
GOPC	hsa-miR-3133	80.3759	NM_001017408
GOPC	hsa-miR-4643	80.1298	NM_001017408

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Motifs and transcription factors (TFs) regulating GOPC

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GOPC	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
GOPC	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
GOPC	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
GOPC	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
GOPC	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
GOPC	cisbp__M07938	E2F1 (directAnnotation).
GOPC	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
GOPC	transfac_pro__M04748	GABPA (directAnnotation).
GOPC	hdpi__TP73	TP73 (directAnnotation).
GOPC	jaspar__MA0776.1	MYBL1 (directAnnotation).
GOPC	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
GOPC	transfac_pro__M04950	EGR1 (directAnnotation).
GOPC	transfac_pro__M00652	NRF1 (directAnnotation).
GOPC	metacluster_55.5	ZNF541 (directAnnotation).
GOPC	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
GOPC	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
GOPC	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
GOPC	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
GOPC	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."