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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GNB4

Summary for GNB4

Gene information	Gene symbol	GNB4
	Ensembl ID	ENSG00000114450
	Entrez ID	59345
	Gene name	G protein subunit beta 4
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9HAV0

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Dataset with differentially expressed gene: GNB4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.363151	5.69e-05
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.380185	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.253054	1.62e-11

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Expression of GNB4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GNB4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GNB4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GNB4	hsa-miR-4478	86.389	NM_021629
GNB4	hsa-miR-6760-3p	86.3415	NM_021629
GNB4	hsa-miR-3059-5p	86.3345	NM_021629
GNB4	hsa-miR-4503	86.2176	NM_021629
GNB4	hsa-miR-300	86.1648	NM_021629
GNB4	hsa-miR-381-3p	86.1648	NM_021629
GNB4	hsa-miR-548c-3p	85.4623	NM_021629
GNB4	hsa-miR-3925-3p	85.4525	NM_021629
GNB4	hsa-miR-5100	84.8486	NM_021629
GNB4	hsa-miR-6765-3p	84.6311	NM_021629
GNB4	hsa-miR-3622b-3p	84.6311	NM_021629
GNB4	hsa-miR-3622a-3p	84.6311	NM_021629
GNB4	hsa-miR-1208	84.2259	NM_021629
GNB4	hsa-miR-125b-2-3p	83.765	NM_021629
GNB4	hsa-miR-1299	82.7312	NM_021629
GNB4	hsa-miR-29c-3p	82.5427	NM_021629
GNB4	hsa-miR-29b-3p	82.5427	NM_021629
GNB4	hsa-miR-29a-3p	82.5427	NM_021629
GNB4	hsa-miR-6888-5p	82.3421	NM_021629
GNB4	hsa-miR-877-5p	81.9641	NM_021629
GNB4	hsa-miR-7702	81.3839	NM_021629
GNB4	hsa-miR-548e-5p	81.2129	NM_021629
GNB4	hsa-miR-4269	80.8859	NM_021629
GNB4	hsa-miR-6715b-5p	80.8859	NM_021629
GNB4	hsa-miR-4775	80.7902	NM_021629
GNB4	hsa-miR-3074-3p	80.4871	NM_021629

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Motifs and transcription factors (TFs) regulating GNB4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GNB4	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
GNB4	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
GNB4	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
GNB4	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
GNB4	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
GNB4	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
GNB4	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
GNB4	metacluster_81.7	CREB1 (directAnnotation).
GNB4	transfac_pro__M01298	MECP2 (directAnnotation).
GNB4	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
GNB4	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
GNB4	transfac_pro__M02089	E2F3 (directAnnotation).
GNB4	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
GNB4	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
GNB4	transfac_pro__M04817	ZBTB33 (directAnnotation).
GNB4	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
GNB4	tfdimers__MD00483	ZBTB14 (directAnnotation).
GNB4	cisbp__M07938	E2F1 (directAnnotation).
GNB4	cisbp__M00968	MTF2 (directAnnotation).
GNB4	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
GNB4	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
GNB4	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
GNB4	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
GNB4	jaspar__MA1122.1	TFDP1 (directAnnotation).
GNB4	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
GNB4	transfac_pro__M05605	GATA6 (inferredBy_Orthology).
GNB4	metacluster_62.3	HSF5 (directAnnotation).
GNB4	transfac_pro__M05985	ZNF394 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."