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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GCC2

Summary for GCC2

Gene information	Gene symbol	GCC2
	Ensembl ID	ENSG00000135968
	Entrez ID	9648
	Gene name	GRIP and coiled-coil domain containing 2
	Synonyms	GCC185\|KIAA0336
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: GCC2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.381775	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.280506	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.27803	5.78e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.253718	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.294636	1.28e-28
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD8+ T cells	-0.308583	3.23e-07
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.370932	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.334642	1.05e-11

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Expression of GCC2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GCC2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GCC2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GCC2	hsa-miR-181b-5p	87.1994	NM_181453
GCC2	hsa-miR-181a-5p	87.1994	NM_181453
GCC2	hsa-miR-548aj-5p	86.5531	NM_181453
GCC2	hsa-miR-548f-5p	86.5531	NM_181453
GCC2	hsa-miR-548g-5p	86.5531	NM_181453
GCC2	hsa-miR-548x-5p	86.5531	NM_181453
GCC2	hsa-miR-4291	86.2614	NM_181453
GCC2	hsa-miR-195-5p	85.1465	NM_181453
GCC2	hsa-miR-15a-5p	85.1465	NM_181453
GCC2	hsa-miR-6838-5p	85.1465	NM_181453
GCC2	hsa-miR-16-5p	85.1465	NM_181453
GCC2	hsa-miR-15b-5p	85.1465	NM_181453
GCC2	hsa-miR-26b-3p	84.6694	NM_181453
GCC2	hsa-miR-3682-5p	84.5377	NM_181453
GCC2	hsa-miR-603	84.4067	NM_181453
GCC2	hsa-let-7f-2-3p	84.3789	NM_181453
GCC2	hsa-miR-1185-2-3p	84.3789	NM_181453
GCC2	hsa-miR-1185-1-3p	84.3789	NM_181453
GCC2	hsa-miR-5590-3p	84.2379	NM_181453
GCC2	hsa-miR-142-5p	84.2379	NM_181453
GCC2	hsa-miR-3681-3p	84.0439	NM_181453
GCC2	hsa-miR-22-5p	83.7586	NM_181453
GCC2	hsa-miR-520a-5p	82.6518	NM_181453
GCC2	hsa-miR-525-5p	82.6518	NM_181453
GCC2	hsa-miR-494-3p	82.3736	NM_181453
GCC2	hsa-miR-7111-3p	82.1443	NM_181453
GCC2	hsa-miR-532-5p	81.7436	NM_181453
GCC2	hsa-miR-5680	81.0324	NM_181453
GCC2	hsa-miR-424-5p	80.9989	NM_181453
GCC2	hsa-miR-497-5p	80.9989	NM_181453
GCC2	hsa-miR-1468-3p	80.8553	NM_181453

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Motifs and transcription factors (TFs) regulating GCC2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GCC2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
GCC2	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
GCC2	hdpi__ETV4	ETV4 (directAnnotation).
GCC2	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
GCC2	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
GCC2	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
GCC2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
GCC2	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
GCC2	transfac_pro__M06448	ZNF808 (directAnnotation).
GCC2	transfac_pro__M06042	ZNF208 (directAnnotation).
GCC2	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
GCC2	taipale_tf_pairs__ETV5_DLX2_RSCGGAANNNNNYAATTA_CAP	DLX2; ETV5 (directAnnotation).
GCC2	swissregulon__hs__ETV6	ETV6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."