Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FXR1

Summary for FXR1

Gene information	Gene symbol	FXR1
	Ensembl ID	ENSG00000114416
	Entrez ID	8087
	Gene name	FMR1 autosomal homolog 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: FXR1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.296762	4.60e-18
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.501912	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.251256	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.415404	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.412561	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.683952	4.19e-04
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.435726	4.67e-21

Top

Expression of FXR1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to FXR1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating FXR1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FXR1	hsa-miR-942-5p	86.5865	NM_001013438
FXR1	hsa-miR-137-3p	86.4389	NM_001013438
FXR1	hsa-miR-182-5p	86.3307	NM_005087
FXR1	hsa-miR-155-5p	86.2341	NM_005087
FXR1	hsa-miR-1278	85.9097	NM_005087
FXR1	hsa-miR-3682-3p	85.696	NM_005087
FXR1	hsa-miR-5580-3p	85.6468	NM_005087
FXR1	hsa-miR-4721	85.0615	NM_005087
FXR1	hsa-miR-125a-3p	85.0323	NM_005087
FXR1	hsa-miR-4769-3p	84.6786	NM_005087
FXR1	hsa-miR-6817-5p	84.6786	NM_005087
FXR1	hsa-miR-4276	84.5728	NM_001013438
FXR1	hsa-miR-363-3p	84.5495	NM_001013438
FXR1	hsa-miR-25-3p	84.5495	NM_001013438
FXR1	hsa-miR-367-3p	84.5495	NM_001013438
FXR1	hsa-miR-4511	84.5022	NM_005087
FXR1	hsa-miR-4452	84.3463	NM_001013438
FXR1	hsa-miR-618	84.1486	NM_005087
FXR1	hsa-miR-4307	84.0612	NM_005087
FXR1	hsa-miR-151a-3p	84.0322	NM_005087
FXR1	hsa-miR-570-3p	83.9498	NM_005087
FXR1	hsa-miR-9983-3p	83.3718	NM_001013438
FXR1	hsa-miR-337-3p	83.3655	NM_001013438
FXR1	hsa-miR-651-3p	82.6197	NM_005087
FXR1	hsa-miR-186-5p	81.8212	NM_005087
FXR1	hsa-miR-3185	81.5424	NM_005087
FXR1	hsa-miR-3148	80.8027	NM_005087
FXR1	hsa-miR-4715-3p	80.7426	NM_005087
FXR1	hsa-miR-6864-3p	80.4985	NM_005087
FXR1	hsa-miR-3672	80.4985	NM_005087
FXR1	hsa-miR-129-5p	80.2545	NM_001013438
FXR1	hsa-miR-6785-3p	80.1745	NM_001013438
FXR1	hsa-miR-5011-5p	80.0666	NM_005087

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating FXR1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FXR1	transfac_pro__M07436	WT1 (directAnnotation).
FXR1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
FXR1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
FXR1	transfac_pro__M02089	E2F3 (directAnnotation).
FXR1	transfac_pro__M01122	ZNF219 (directAnnotation).
FXR1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
FXR1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
FXR1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
FXR1	transfac_pro__M08819	KLF2 (directAnnotation).
FXR1	transfac_pro__M01175	ZBTB7B (directAnnotation).
FXR1	cisbp__M00249	WT1 (directAnnotation).
FXR1	transfac_pro__M01118	WT1 (directAnnotation).
FXR1	swissregulon__hs__KLF6	KLF6 (directAnnotation).
FXR1	transfac_pro__M01303	SP1 (directAnnotation).
FXR1	transfac_pro__M04595	SALL2 (directAnnotation).
FXR1	transfac_pro__M00716	ZBTB14 (directAnnotation).
FXR1	metacluster_133.2	CPSF4; CPSF4; E2F4; FOXO3; KLF13; KLF15; KLF17; KLF5; MAZ; MAZ; MAZ; MZF1; PATZ1; PATZ1; PATZ1; PATZ1; PLAG1; PRDM9; SP4; VEZF1; WT1; ZBTB17; ZBTB7A; ZBTB7A; ZBTB7B; ZNF148; ZNF148; ZNF148; ZNF148; ZNF180; ZNF180; ZNF202; ZNF219; ZNF219; ZNF263; ZNF263; ZNF28; ZNF281; ZNF281; ZNF281; ZNF281; ZNF281; ZNF383; ZNF398; ZNF398; ZNF444; ZNF444; ZNF467; ZNF543; ZNF543; ZNF641; ZNF692; ZNF737; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF880; ZNF880 (directAnnotation). MAZ; PLAG1; PLAGL1; SP1; SP5; SP5; ZBTB17; ZNF281; ZNF281; ZNF281; ZNF641; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
FXR1	transfac_pro__M07397	ZNF148 (directAnnotation).
FXR1	transfac_pro__M00807	EGR1; EGR2; EGR3 (directAnnotation).
FXR1	transfac_pro__M01104	OVOL2 (directAnnotation).
FXR1	transfac_pro__M06520	ZNF721 (directAnnotation).
FXR1	transfac_pro__M00986	CHURC1 (directAnnotation).
FXR1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FXR1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FXR1	metacluster_7.13	ZFX (directAnnotation).
FXR1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
FXR1	cisbp__M00968	MTF2 (directAnnotation).
FXR1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
FXR1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
FXR1	cisbp__M00341	PAX6 (directAnnotation).
FXR1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
FXR1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FXR1	cisbp__M00788	ZFY (inferredBy_Orthology).
FXR1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
FXR1	metacluster_175.1	ZNF283 (directAnnotation).
FXR1	hdpi__ZNF304	ZNF304 (directAnnotation).
FXR1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
FXR1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
FXR1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
FXR1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
FXR1	metacluster_151.2	ZNF23 (directAnnotation).
FXR1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FXR1	transfac_pro__M03806	ZBTB7C (directAnnotation).
FXR1	hdpi__TP73	TP73 (directAnnotation).
FXR1	transfac_pro__M04826	EP300 (directAnnotation).
FXR1	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
FXR1	transfac_pro__M04794	TAF1 (directAnnotation).
FXR1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
FXR1	jaspar__MA0748.2	YY2 (directAnnotation).
FXR1	metacluster_182.10	ZFX (directAnnotation).

Page: 1 2 3

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."