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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FRS2

Summary for FRS2

Gene information	Gene symbol	FRS2
	Ensembl ID	ENSG00000166225
	Entrez ID	10818
	Gene name	fibroblast growth factor receptor substrate 2
	Synonyms	FRS2A\|FRS2alpha\|SNT-1\|SNT1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FRS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.43575	0.00e+00

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Expression of FRS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FRS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FRS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FRS2	hsa-miR-548j-3p	92.2916	NM_001278354
FRS2	hsa-miR-548am-3p	92.2916	NM_001278354
FRS2	hsa-miR-548ah-3p	92.2916	NM_001278354
FRS2	hsa-miR-548ae-3p	92.2916	NM_001278354
FRS2	hsa-miR-548aq-3p	92.2916	NM_001278354
FRS2	hsa-miR-6835-3p	92.0531	NM_001042555
FRS2	hsa-miR-1911-5p	91.778	NM_001042555
FRS2	hsa-miR-31-3p	91.3374	NM_001278354
FRS2	hsa-miR-3121-3p	91.3266	NM_001042555
FRS2	hsa-miR-622	91.3061	NM_001042555
FRS2	hsa-miR-590-3p	91.0066	NM_001042555
FRS2	hsa-miR-6088	90.6356	NM_001042555
FRS2	hsa-miR-3680-3p	90.2666	NM_001042555
FRS2	hsa-miR-6886-3p	90.1318	NM_001042555
FRS2	hsa-miR-6760-5p	90.0953	NM_001278354
FRS2	hsa-miR-624-5p	89.1768	NM_001042555
FRS2	hsa-miR-6747-3p	89.1745	NM_001042555
FRS2	hsa-miR-580-5p	88.6636	NM_001278354
FRS2	hsa-miR-4470	88.6109	NM_001042555
FRS2	hsa-miR-4735-3p	88.4736	NM_001042555
FRS2	hsa-miR-18a-5p	88.4736	NM_001042555
FRS2	hsa-miR-18b-5p	88.4736	NM_001042555
FRS2	hsa-miR-607	88.4474	NM_001278354
FRS2	hsa-miR-4659b-5p	88.1148	NM_001042555
FRS2	hsa-miR-593-3p	87.9656	NM_001042555
FRS2	hsa-miR-335-3p	87.9585	NM_001042555
FRS2	hsa-miR-224-5p	87.9373	NM_001042555
FRS2	hsa-miR-6715a-3p	87.4665	NM_001042555
FRS2	hsa-miR-4422	87.3407	NM_001042555
FRS2	hsa-miR-4423-3p	87.0394	NM_001042555
FRS2	hsa-miR-4659a-5p	86.746	NM_001042555
FRS2	hsa-miR-539-5p	86.6977	NM_001278354
FRS2	hsa-miR-122b-5p	86.6433	NM_001278354
FRS2	hsa-miR-541-5p	86.3757	NM_001278354
FRS2	hsa-miR-4796-3p	86.2842	NM_001042555
FRS2	hsa-miR-515-5p	86.2682	NM_001278354
FRS2	hsa-miR-519e-5p	86.2682	NM_001278354
FRS2	hsa-miR-5590-5p	86.049	NM_001042555
FRS2	hsa-miR-4708-5p	86.0086	NM_001042555
FRS2	hsa-miR-9851-5p	85.3534	NM_001042555
FRS2	hsa-miR-6855-5p	85.2312	NM_001278354
FRS2	hsa-miR-340-5p	85.1966	NM_001278354
FRS2	hsa-miR-4310	84.9206	NM_001042555
FRS2	hsa-miR-548c-3p	84.8448	NM_001278354
FRS2	hsa-miR-4766-3p	84.7892	NM_001278354
FRS2	hsa-miR-4718	84.7516	NM_001278354
FRS2	hsa-miR-548o-3p	84.0996	NM_001278354
FRS2	hsa-miR-8080	83.7752	NM_001278354
FRS2	hsa-miR-5009-3p	83.7086	NM_001278354
FRS2	hsa-miR-630	83.2824	NM_001278354

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Motifs and transcription factors (TFs) regulating FRS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FRS2	metacluster_135.11	NR2C2 (directAnnotation).
FRS2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FRS2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FRS2	metacluster_7.13	ZFX (directAnnotation).
FRS2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
FRS2	cisbp__M00968	MTF2 (directAnnotation).
FRS2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
FRS2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
FRS2	cisbp__M00341	PAX6 (directAnnotation).
FRS2	metacluster_198.3	ZFP64 (directAnnotation).
FRS2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
FRS2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
FRS2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
FRS2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FRS2	cisbp__M00788	ZFY (inferredBy_Orthology).
FRS2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
FRS2	metacluster_175.1	ZNF283 (directAnnotation).
FRS2	hdpi__ZNF304	ZNF304 (directAnnotation).
FRS2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
FRS2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
FRS2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
FRS2	transfac_pro__M01199	TRIM28 (directAnnotation).
FRS2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
FRS2	metacluster_151.2	ZNF23 (directAnnotation).
FRS2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FRS2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
FRS2	transfac_pro__M03806	ZBTB7C (directAnnotation).
FRS2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."