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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FRMD4B

Summary for FRMD4B

Gene information	Gene symbol	FRMD4B
	Ensembl ID	ENSG00000114541
	Entrez ID	23150
	Gene name	FERM domain containing 4B
	Synonyms	GRSP1\|KIAA1013
	Gene type	protein_coding
	UniProtAcc	Q9Y2L6

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Dataset with differentially expressed gene: FRMD4B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.273489	6.57e-09
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.352956	4.45e-34
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.973406	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.01574	2.73e-33

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Expression of FRMD4B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FRMD4B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FRMD4B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FRMD4B	hsa-miR-196a-5p	84.7252	NM_015123
FRMD4B	hsa-miR-95-5p	84.7091	NM_015123
FRMD4B	hsa-miR-12136	84.4439	NM_015123
FRMD4B	hsa-miR-335-3p	84.3312	NM_015123
FRMD4B	hsa-miR-192-5p	83.6456	NM_015123
FRMD4B	hsa-miR-215-5p	83.6456	NM_015123
FRMD4B	hsa-miR-5691	83.6412	NM_015123
FRMD4B	hsa-miR-5196-3p	82.9562	NM_015123
FRMD4B	hsa-miR-12115	82.8545	NM_015123
FRMD4B	hsa-miR-186-5p	82.6292	NM_015123
FRMD4B	hsa-miR-6796-5p	82.5424	NM_015123
FRMD4B	hsa-miR-429	82.0042	NM_015123
FRMD4B	hsa-miR-4517	81.4764	NM_015123
FRMD4B	hsa-miR-7-1-3p	80.6432	NM_015123
FRMD4B	hsa-miR-7-2-3p	80.6432	NM_015123
FRMD4B	hsa-miR-515-5p	80.3005	NM_015123
FRMD4B	hsa-miR-519e-5p	80.3005	NM_015123
FRMD4B	hsa-miR-3663-3p	80.059	NM_015123

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Motifs and transcription factors (TFs) regulating FRMD4B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FRMD4B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FRMD4B	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
FRMD4B	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
FRMD4B	cisbp__M00968	MTF2 (directAnnotation).
FRMD4B	metacluster_135.11	NR2C2 (directAnnotation).
FRMD4B	metacluster_160.20	JUND; PRDM15 (directAnnotation).
FRMD4B	metacluster_198.3	ZFP64 (directAnnotation).
FRMD4B	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FRMD4B	metacluster_175.1	ZNF283 (directAnnotation).
FRMD4B	transfac_pro__M01861	ATF1 (directAnnotation).
FRMD4B	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
FRMD4B	metacluster_111.5	E4F1; E4F1 (directAnnotation).
FRMD4B	transfac_pro__M04817	ZBTB33 (directAnnotation).
FRMD4B	transfac_pro__M05402	BCL6B (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."