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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FOXJ3

Summary for FOXJ3

Gene information	Gene symbol	FOXJ3
	Ensembl ID	ENSG00000198815
	Entrez ID	22887
	Gene name	forkhead box J3
	Synonyms	KIAA1041
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FOXJ3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.355782	2.87e-26

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Expression of FOXJ3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FOXJ3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FOXJ3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FOXJ3	hsa-miR-4782-3p	88.8015	NM_001198850
FOXJ3	hsa-miR-219a-5p	88.8015	NM_001198850
FOXJ3	hsa-let-7c-3p	88.1546	NM_001198850
FOXJ3	hsa-let-7a-2-3p	88.1546	NM_001198850
FOXJ3	hsa-let-7g-3p	88.1546	NM_001198850
FOXJ3	hsa-miR-548av-3p	88.1384	NM_001198850
FOXJ3	hsa-miR-4277	87.6113	NM_001198850
FOXJ3	hsa-miR-3942-5p	87.4761	NM_001198850
FOXJ3	hsa-miR-4703-5p	87.1766	NM_001198850
FOXJ3	hsa-miR-4796-3p	86.5695	NM_001198850
FOXJ3	hsa-miR-466	86.3642	NM_001198850
FOXJ3	hsa-miR-1468-3p	86.3027	NM_001198850
FOXJ3	hsa-miR-29a-5p	86.054	NM_001198850
FOXJ3	hsa-miR-3685	85.7002	NM_001198850
FOXJ3	hsa-miR-4536-3p	85.6778	NM_001198850
FOXJ3	hsa-miR-3128	85.146	NM_001198850
FOXJ3	hsa-miR-517b-3p	83.613	NM_001198850
FOXJ3	hsa-miR-517c-3p	83.613	NM_001198850
FOXJ3	hsa-miR-517a-3p	83.613	NM_001198850
FOXJ3	hsa-miR-10397-5p	83.5307	NM_001198850
FOXJ3	hsa-miR-4803	83.4701	NM_001198850
FOXJ3	hsa-miR-6505-5p	83.3428	NM_001198850
FOXJ3	hsa-miR-431-5p	82.8011	NM_001198850
FOXJ3	hsa-miR-9902	82.7223	NM_001198850
FOXJ3	hsa-miR-5697	82.6788	NM_001198850
FOXJ3	hsa-miR-545-5p	82.2831	NM_001198850
FOXJ3	hsa-miR-4799-3p	82.0602	NM_001198850
FOXJ3	hsa-miR-5588-5p	82.0602	NM_001198850
FOXJ3	hsa-miR-4720-5p	82.0602	NM_001198850
FOXJ3	hsa-miR-4698	81.4035	NM_001198850
FOXJ3	hsa-miR-1183	81.0823	NM_001198850
FOXJ3	hsa-miR-935	81.0047	NM_001198850
FOXJ3	hsa-miR-2276-5p	80.8114	NM_001198850
FOXJ3	hsa-miR-95-5p	80.7654	NM_001198850
FOXJ3	hsa-miR-1207-5p	80.6062	NM_001198850
FOXJ3	hsa-miR-548aj-3p	80.5324	NM_001198850
FOXJ3	hsa-miR-548x-3p	80.5324	NM_001198850
FOXJ3	hsa-miR-664a-3p	80.2449	NM_001198850
FOXJ3	hsa-miR-498-5p	80.0956	NM_001198850

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Motifs and transcription factors (TFs) regulating FOXJ3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FOXJ3	metacluster_135.11	NR2C2 (directAnnotation).
FOXJ3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FOXJ3	tfdimers__MD00038	TFAP2C (directAnnotation).
FOXJ3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FOXJ3	metacluster_7.13	ZFX (directAnnotation).
FOXJ3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
FOXJ3	cisbp__M00968	MTF2 (directAnnotation).
FOXJ3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
FOXJ3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
FOXJ3	cisbp__M00341	PAX6 (directAnnotation).
FOXJ3	metacluster_198.3	ZFP64 (directAnnotation).
FOXJ3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
FOXJ3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
FOXJ3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
FOXJ3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FOXJ3	cisbp__M00788	ZFY (inferredBy_Orthology).
FOXJ3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
FOXJ3	metacluster_175.1	ZNF283 (directAnnotation).
FOXJ3	hdpi__ZNF304	ZNF304 (directAnnotation).
FOXJ3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
FOXJ3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
FOXJ3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
FOXJ3	transfac_pro__M01199	TRIM28 (directAnnotation).
FOXJ3	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
FOXJ3	metacluster_151.2	ZNF23 (directAnnotation).
FOXJ3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FOXJ3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
FOXJ3	transfac_pro__M03806	ZBTB7C (directAnnotation).
FOXJ3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."