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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FNIP1

Summary for FNIP1

Gene information	Gene symbol	FNIP1
	Ensembl ID	ENSG00000217128
	Entrez ID	96459
	Gene name	folliculin interacting protein 1
	Synonyms	KIAA1961
	Gene type	protein_coding
	UniProtAcc	Q8TF40

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Dataset with differentially expressed gene: FNIP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.52677	4.40e-40
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.33693	1.39e-12
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.339252	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.314274	0.00e+00

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Expression of FNIP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FNIP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FNIP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FNIP1	hsa-miR-4728-5p	88.6964	NM_133372
FNIP1	hsa-miR-5580-3p	88.6316	NM_001008738
FNIP1	hsa-miR-4775	88.4627	NM_001008738
FNIP1	hsa-miR-589-3p	88.1948	NM_133372
FNIP1	hsa-miR-379-3p	88.1872	NM_001008738
FNIP1	hsa-miR-411-3p	88.1872	NM_001008738
FNIP1	hsa-miR-7106-5p	87.8573	NM_133372
FNIP1	hsa-miR-579-3p	87.8237	NM_133372
FNIP1	hsa-miR-664b-3p	87.8237	NM_133372
FNIP1	hsa-miR-7157-5p	87.8116	NM_133372
FNIP1	hsa-miR-3664-3p	87.7795	NM_001008738
FNIP1	hsa-miR-7162-3p	87.7341	NM_001008738
FNIP1	hsa-miR-499a-5p	87.7223	NM_001008738
FNIP1	hsa-miR-1-5p	87.7081	NM_133372
FNIP1	hsa-miR-7152-5p	87.6875	NM_133372
FNIP1	hsa-miR-6729-3p	87.0669	NM_133372
FNIP1	hsa-miR-196a-5p	87.0009	NM_001008738
FNIP1	hsa-miR-196b-5p	87.0009	NM_001008738
FNIP1	hsa-miR-493-5p	86.9374	NM_133372
FNIP1	hsa-miR-4482-3p	86.9164	NM_133372
FNIP1	hsa-miR-137-3p	86.9077	NM_001008738
FNIP1	hsa-miR-6785-5p	86.7937	NM_133372
FNIP1	hsa-miR-5011-5p	86.6995	NM_133372
FNIP1	hsa-miR-188-5p	86.6366	NM_001008738
FNIP1	hsa-miR-6758-3p	86.2207	NM_133372
FNIP1	hsa-miR-3613-3p	85.5221	NM_133372
FNIP1	hsa-miR-655-3p	85.1577	NM_001008738
FNIP1	hsa-miR-374c-5p	85.1577	NM_001008738
FNIP1	hsa-miR-3658	84.9744	NM_133372
FNIP1	hsa-miR-208b-3p	84.8889	NM_001008738
FNIP1	hsa-miR-208a-3p	84.8889	NM_001008738
FNIP1	hsa-miR-3189-3p	84.0234	NM_133372
FNIP1	hsa-miR-1323	83.9256	NM_133372
FNIP1	hsa-miR-548o-3p	83.7394	NM_133372
FNIP1	hsa-miR-4666a-3p	83.722	NM_133372
FNIP1	hsa-miR-149-3p	83.6773	NM_133372
FNIP1	hsa-miR-6883-5p	83.6773	NM_133372
FNIP1	hsa-miR-6866-3p	82.9945	NM_001008738
FNIP1	hsa-miR-4280	82.4271	NM_001008738
FNIP1	hsa-miR-548aw	82.0263	NM_133372
FNIP1	hsa-miR-3177-5p	81.8628	NM_133372
FNIP1	hsa-miR-659-3p	81.5933	NM_001008738
FNIP1	hsa-miR-6780a-5p	81.1401	NM_133372
FNIP1	hsa-miR-3119	80.708	NM_133372
FNIP1	hsa-miR-5692c	80.4628	NM_133372
FNIP1	hsa-miR-5692b	80.4628	NM_133372
FNIP1	hsa-miR-204-5p	80.2491	NM_001008738
FNIP1	hsa-miR-211-5p	80.2491	NM_001008738

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Motifs and transcription factors (TFs) regulating FNIP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FNIP1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
FNIP1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
FNIP1	transfac_pro__M01783	SP2 (directAnnotation).
FNIP1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
FNIP1	cisbp__M00341	PAX6 (directAnnotation).
FNIP1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
FNIP1	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
FNIP1	transfac_pro__M01253	CNOT3 (directAnnotation).
FNIP1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
FNIP1	metacluster_7.13	ZFX (directAnnotation).
FNIP1	cisbp__M00968	MTF2 (directAnnotation).
FNIP1	transfac_pro__M04817	ZBTB33 (directAnnotation).
FNIP1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
FNIP1	transfac_pro__M02089	E2F3 (directAnnotation).
FNIP1	jaspar__MA0748.2	YY2 (directAnnotation).
FNIP1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
FNIP1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
FNIP1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
FNIP1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
FNIP1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FNIP1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
FNIP1	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
FNIP1	transfac_pro__M12686	ZBTB10 (directAnnotation).
FNIP1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
FNIP1	metacluster_143.14	ZNF320 (directAnnotation).
FNIP1	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
FNIP1	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
FNIP1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
FNIP1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FNIP1	kznf__ZNF141_Imbeault2017_RP_RCADE	ZNF141 (directAnnotation).
FNIP1	transfac_pro__M04617	ZBTB7A (directAnnotation).
FNIP1	transfac_pro__M01973	PLAG1 (directAnnotation).
FNIP1	metacluster_151.2	ZNF23 (directAnnotation).
FNIP1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
FNIP1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
FNIP1	metacluster_66.1	MTF1; ZNF320; ZNF320; ZNF320; ZNF782 (directAnnotation).
FNIP1	cisbp__M01864	EGR1 (inferredBy_Orthology).
FNIP1	tfdimers__MD00391	KLF4 (directAnnotation).
FNIP1	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
FNIP1	transfac_pro__M05479	ZNF580 (directAnnotation).
FNIP1	tfdimers__MD00151	CHURC1 (directAnnotation).
FNIP1	cisbp__M00139	ZNF281 (inferredBy_Orthology).
FNIP1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
FNIP1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
FNIP1	transfac_public__M00491	PATZ1 (directAnnotation).
FNIP1	jaspar__MA1122.1	TFDP1 (directAnnotation).
FNIP1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
FNIP1	metacluster_159.5	ZIC1; ZIC4; ZNF423 (directAnnotation). SP1 (inferredBy_Orthology).
FNIP1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
FNIP1	transfac_pro__M01199	TRIM28 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."