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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FMNL2

Summary for FMNL2

Gene information	Gene symbol	FMNL2
	Ensembl ID	ENSG00000157827
	Entrez ID	114793
	Gene name	formin like 2
	Synonyms	FHOD2\|KIAA1902
	Gene type	protein_coding
	UniProtAcc	Q96PY5

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Dataset with differentially expressed gene: FMNL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.998995	1.18e-05
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.276061	1.48e-12

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Expression of FMNL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FMNL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FMNL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FMNL2	hsa-miR-548y	92.1527	NM_052905
FMNL2	hsa-miR-548i	92.1527	NM_052905
FMNL2	hsa-miR-548c-5p	92.1527	NM_052905
FMNL2	hsa-miR-548ar-5p	92.1527	NM_052905
FMNL2	hsa-miR-548w	92.1527	NM_052905
FMNL2	hsa-miR-548ak	92.1527	NM_052905
FMNL2	hsa-miR-3674	91.8435	NM_052905
FMNL2	hsa-miR-487b-5p	90.9506	NM_052905
FMNL2	hsa-miR-487a-5p	90.9506	NM_052905
FMNL2	hsa-miR-4311	90.4028	NM_052905
FMNL2	hsa-miR-659-3p	90.3379	NM_052905
FMNL2	hsa-miR-4639-5p	90.0387	NM_052905
FMNL2	hsa-miR-493-5p	89.4111	NM_052905
FMNL2	hsa-miR-1251-3p	88.6531	NM_052905
FMNL2	hsa-miR-3686	88.4323	NM_052905
FMNL2	hsa-miR-4261	88.304	NM_052905
FMNL2	hsa-miR-129-1-3p	88.2703	NM_052905
FMNL2	hsa-miR-129-2-3p	88.2703	NM_052905
FMNL2	hsa-miR-1225-3p	87.7378	NM_052905
FMNL2	hsa-miR-16-2-3p	86.6258	NM_052905
FMNL2	hsa-miR-195-3p	86.6258	NM_052905
FMNL2	hsa-miR-302f	86.4797	NM_052905
FMNL2	hsa-miR-6754-3p	86.0177	NM_052905
FMNL2	hsa-miR-412-3p	86.0177	NM_052905
FMNL2	hsa-miR-376a-2-5p	84.8321	NM_052905
FMNL2	hsa-miR-147b-5p	84.1303	NM_052905
FMNL2	hsa-miR-5582-5p	84.043	NM_052905
FMNL2	hsa-miR-548p	83.8206	NM_052905
FMNL2	hsa-miR-219b-3p	83.1692	NM_052905
FMNL2	hsa-miR-155-5p	82.8376	NM_052905
FMNL2	hsa-miR-8084	82.0618	NM_052905
FMNL2	hsa-miR-6500-3p	81.8791	NM_052905
FMNL2	hsa-miR-4677-5p	80.9208	NM_052905
FMNL2	hsa-miR-4736	80.7786	NM_052905
FMNL2	hsa-miR-586	80.7684	NM_052905
FMNL2	hsa-miR-4303	80.4142	NM_052905

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Motifs and transcription factors (TFs) regulating FMNL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FMNL2	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
FMNL2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
FMNL2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
FMNL2	transfac_pro__M04617	ZBTB7A (directAnnotation).
FMNL2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
FMNL2	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
FMNL2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
FMNL2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
FMNL2	transfac_pro__M07387	ZBTB7A (directAnnotation).
FMNL2	transfac_pro__M07436	WT1 (directAnnotation).
FMNL2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
FMNL2	transfac_pro__M00716	ZBTB14 (directAnnotation).
FMNL2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
FMNL2	hdpi__HIP2	UBE2K (directAnnotation).
FMNL2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
FMNL2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
FMNL2	transfac_pro__M04893	TAF1 (directAnnotation).
FMNL2	transfac_pro__M03876	ZBTB33 (directAnnotation).
FMNL2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
FMNL2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
FMNL2	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
FMNL2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
FMNL2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
FMNL2	jaspar__MA0079.5	SP1 (directAnnotation).
FMNL2	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
FMNL2	transfac_pro__M01253	CNOT3 (directAnnotation).
FMNL2	transfac_pro__M04817	ZBTB33 (directAnnotation).
FMNL2	transfac_pro__M05712	ZNF134 (directAnnotation).
FMNL2	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."