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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FLRT3

Summary for FLRT3

Gene information	Gene symbol	FLRT3
	Ensembl ID	ENSG00000125848
	Entrez ID	23767
	Gene name	fibronectin leucine rich transmembrane protein 3
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9NZU0

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Dataset with differentially expressed gene: FLRT3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	4.83662	3.76e-05
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.272735	1.77e-09
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.706307	0.00e+00

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Expression of FLRT3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FLRT3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
FLRT3	Malignant cells	CPI-SS08BFFB96E	FLRT3_ADGRL2	FLRT3	ADGRL2	False	Malignant cells	Endothelial cells	GSE207422_Tor	post	resistant

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FLRT3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FLRT3	hsa-miR-6853-3p	91.2322	NM_198391
FLRT3	hsa-miR-542-3p	91.0103	NM_198391
FLRT3	hsa-miR-3191-5p	90.7724	NM_198391
FLRT3	hsa-miR-199a-5p	89.5186	NM_013281
FLRT3	hsa-miR-199b-5p	89.5186	NM_013281
FLRT3	hsa-miR-4645-3p	89.3417	NM_198391
FLRT3	hsa-miR-550b-3p	89.3302	NM_198391
FLRT3	hsa-miR-8076	89.2143	NM_198391
FLRT3	hsa-miR-3973	89.0494	NM_198391
FLRT3	hsa-miR-144-3p	89.0448	NM_013281
FLRT3	hsa-miR-369-3p	88.977	NM_013281
FLRT3	hsa-miR-8084	88.949	NM_198391
FLRT3	hsa-miR-5010-3p	88.2638	NM_198391
FLRT3	hsa-miR-124-5p	88.1133	NM_198391
FLRT3	hsa-miR-1914-5p	87.9963	NM_013281
FLRT3	hsa-miR-450b-5p	87.3958	NM_013281
FLRT3	hsa-miR-2116-5p	86.8961	NM_198391
FLRT3	hsa-miR-5195-3p	86.4819	NM_013281
FLRT3	hsa-miR-145-5p	86.4819	NM_013281
FLRT3	hsa-miR-19b-2-5p	86.3527	NM_013281
FLRT3	hsa-miR-19a-5p	86.3527	NM_013281
FLRT3	hsa-miR-19b-1-5p	86.3527	NM_013281
FLRT3	hsa-miR-124-3p	86.2821	NM_013281
FLRT3	hsa-miR-506-3p	86.2821	NM_013281
FLRT3	hsa-miR-6735-3p	85.7044	NM_013281
FLRT3	hsa-miR-12136	85.6	NM_013281
FLRT3	hsa-miR-224-3p	85.0466	NM_198391
FLRT3	hsa-miR-522-3p	85.0466	NM_198391
FLRT3	hsa-miR-3680-3p	84.7701	NM_013281
FLRT3	hsa-miR-507	84.7701	NM_013281
FLRT3	hsa-miR-548n	84.4067	NM_198391
FLRT3	hsa-miR-148a-5p	83.6279	NM_198391
FLRT3	hsa-miR-4804-3p	83.5298	NM_198391
FLRT3	hsa-miR-218-5p	83.4746	NM_013281
FLRT3	hsa-miR-3926	82.2446	NM_013281
FLRT3	hsa-miR-320a-3p	82.025	NM_013281
FLRT3	hsa-miR-320d	82.025	NM_013281
FLRT3	hsa-miR-320c	82.025	NM_013281
FLRT3	hsa-miR-4429	82.025	NM_013281
FLRT3	hsa-miR-320b	82.025	NM_013281
FLRT3	hsa-miR-548t-5p	81.3288	NM_198391
FLRT3	hsa-miR-548az-5p	81.3288	NM_198391
FLRT3	hsa-miR-6502-3p	80.9927	NM_013281
FLRT3	hsa-miR-1825	80.9304	NM_013281
FLRT3	hsa-miR-9985	80.8296	NM_198391
FLRT3	hsa-miR-27b-3p	80.8296	NM_198391
FLRT3	hsa-miR-27a-3p	80.8296	NM_198391
FLRT3	hsa-miR-12123	80.7405	NM_013281
FLRT3	hsa-miR-29b-2-5p	80.5854	NM_013281
FLRT3	hsa-miR-5582-5p	80.5443	NM_013281

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Motifs and transcription factors (TFs) regulating FLRT3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."