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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FERMT2

Summary for FERMT2

Gene information	Gene symbol	FERMT2
	Ensembl ID	ENSG00000073712
	Entrez ID	10979
	Gene name	FERM domain containing kindlin 2
	Synonyms	KIND2\|mig-2\|PLEKHC1\|UNC112B
	Gene type	protein_coding
	UniProtAcc	Q96AC1

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Dataset with differentially expressed gene: FERMT2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.409118	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.261748	2.79e-06

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Expression of FERMT2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FERMT2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FERMT2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FERMT2	hsa-miR-561-3p	87.4907	NM_001134999
FERMT2	hsa-miR-153-3p	87.4402	NM_001134999
FERMT2	hsa-miR-338-5p	87.3281	NM_001134999
FERMT2	hsa-miR-5094	86.2176	NM_001134999
FERMT2	hsa-miR-200b-3p	85.9828	NM_001134999
FERMT2	hsa-miR-429	85.9828	NM_001134999
FERMT2	hsa-miR-200c-3p	85.9828	NM_001134999
FERMT2	hsa-miR-3121-3p	85.7994	NM_001134999
FERMT2	hsa-miR-6792-5p	85.4212	NM_001134999
FERMT2	hsa-miR-32-3p	85.2609	NM_001134999
FERMT2	hsa-miR-7153-3p	84.9522	NM_001134999
FERMT2	hsa-miR-506-3p	84.8316	NM_001134999
FERMT2	hsa-miR-124-3p	84.8316	NM_001134999
FERMT2	hsa-miR-6885-3p	84.3901	NM_001134999
FERMT2	hsa-miR-548x-3p	84.3776	NM_001134999
FERMT2	hsa-miR-548aj-3p	84.3776	NM_001134999
FERMT2	hsa-miR-6131	84.3764	NM_001134999
FERMT2	hsa-miR-133a-5p	84.3764	NM_001134999
FERMT2	hsa-miR-323a-3p	84.0785	NM_001134999
FERMT2	hsa-miR-548g-3p	83.8225	NM_001134999
FERMT2	hsa-miR-4673	83.6582	NM_001134999
FERMT2	hsa-miR-323b-3p	83.2909	NM_001134999
FERMT2	hsa-miR-3714	83.2514	NM_001134999
FERMT2	hsa-miR-548ae-3p	83.2329	NM_001134999
FERMT2	hsa-miR-548aq-3p	83.2329	NM_001134999
FERMT2	hsa-miR-4503	83.1161	NM_001134999
FERMT2	hsa-miR-4650-5p	83.0196	NM_001134999
FERMT2	hsa-miR-4645-5p	82.962	NM_001134999
FERMT2	hsa-miR-144-5p	82.824	NM_001134999
FERMT2	hsa-miR-4282	82.3494	NM_001134999
FERMT2	hsa-miR-8080	81.7629	NM_001134999
FERMT2	hsa-miR-548an	81.6732	NM_001134999
FERMT2	hsa-miR-4276	81.2719	NM_001134999
FERMT2	hsa-let-7c-3p	81.1806	NM_001134999
FERMT2	hsa-miR-3682-5p	81.1193	NM_001134999
FERMT2	hsa-miR-548am-3p	80.7241	NM_001134999
FERMT2	hsa-miR-548j-3p	80.7241	NM_001134999
FERMT2	hsa-miR-548ah-3p	80.7241	NM_001134999
FERMT2	hsa-miR-6868-3p	80.3635	NM_001134999

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Motifs and transcription factors (TFs) regulating FERMT2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FERMT2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
FERMT2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
FERMT2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
FERMT2	transfac_pro__M04866	HDAC2 (directAnnotation).
FERMT2	jaspar__MA1122.1	TFDP1 (directAnnotation).
FERMT2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
FERMT2	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
FERMT2	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
FERMT2	taipale_tf_pairs__ETV5_HOXA13_NNCGGAWGTNRTWAA_CAP	ETV5; HOXA13 (directAnnotation).
FERMT2	transfac_pro__M04748	GABPA (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."