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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FBXO33

Summary for FBXO33

Gene information	Gene symbol	FBXO33
	Ensembl ID	ENSG00000165355
	Entrez ID	254170
	Gene name	F-box protein 33
	Synonyms	Fbx33
	Gene type	protein_coding
	UniProtAcc	Q7Z6M2

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Dataset with differentially expressed gene: FBXO33

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.303406	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.281772	5.61e-44
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.353762	0.00e+00

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Expression of FBXO33 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FBXO33

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FBXO33

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FBXO33	hsa-miR-140-3p	89.0566	NM_203301
FBXO33	hsa-miR-186-5p	89.0104	NM_203301
FBXO33	hsa-miR-98-3p	88.4428	NM_203301
FBXO33	hsa-let-7a-3p	88.4428	NM_203301
FBXO33	hsa-let-7f-1-3p	88.4428	NM_203301
FBXO33	hsa-let-7b-3p	88.4428	NM_203301
FBXO33	hsa-miR-92a-2-5p	88.4164	NM_203301
FBXO33	hsa-miR-4426	87.6979	NM_203301
FBXO33	hsa-miR-367-5p	87.6848	NM_203301
FBXO33	hsa-miR-12136	87.6797	NM_203301
FBXO33	hsa-miR-2113	87.5844	NM_203301
FBXO33	hsa-miR-4330	86.6425	NM_203301
FBXO33	hsa-miR-3119	86.316	NM_203301
FBXO33	hsa-miR-3143	86.152	NM_203301
FBXO33	hsa-miR-4662b	85.9076	NM_203301
FBXO33	hsa-miR-6730-3p	85.75	NM_203301
FBXO33	hsa-miR-1284	85.6598	NM_203301
FBXO33	hsa-miR-4433a-3p	85.6027	NM_203301
FBXO33	hsa-miR-3660	85.6	NM_203301
FBXO33	hsa-miR-4789-5p	85.4125	NM_203301
FBXO33	hsa-miR-493-5p	85.1726	NM_203301
FBXO33	hsa-miR-190a-3p	85.0201	NM_203301
FBXO33	hsa-miR-3159	84.9107	NM_203301
FBXO33	hsa-miR-4262	84.5548	NM_203301
FBXO33	hsa-miR-646	84.1783	NM_203301
FBXO33	hsa-miR-4647	84.1414	NM_203301
FBXO33	hsa-miR-6868-5p	83.821	NM_203301
FBXO33	hsa-miR-95-5p	83.4941	NM_203301
FBXO33	hsa-miR-450a-1-3p	83.4549	NM_203301
FBXO33	hsa-miR-6844	83.3746	NM_203301
FBXO33	hsa-miR-155-5p	83.3324	NM_203301
FBXO33	hsa-miR-377-3p	83.2547	NM_203301
FBXO33	hsa-miR-579-3p	83.2428	NM_203301
FBXO33	hsa-miR-664b-3p	83.2428	NM_203301
FBXO33	hsa-miR-4803	82.8418	NM_203301
FBXO33	hsa-miR-2052	82.4901	NM_203301
FBXO33	hsa-miR-9-3p	82.436	NM_203301
FBXO33	hsa-miR-3171	81.9257	NM_203301
FBXO33	hsa-miR-92a-3p	81.7539	NM_203301
FBXO33	hsa-miR-3124-3p	80.8022	NM_203301
FBXO33	hsa-miR-4526	80.7624	NM_203301
FBXO33	hsa-miR-205-5p	80.6753	NM_203301
FBXO33	hsa-miR-548ay-3p	80.609	NM_203301
FBXO33	hsa-miR-548at-3p	80.609	NM_203301
FBXO33	hsa-miR-1207-3p	80.367	NM_203301
FBXO33	hsa-miR-22-5p	80.2702	NM_203301
FBXO33	hsa-miR-548at-5p	80.1799	NM_203301
FBXO33	hsa-miR-3714	80.1075	NM_203301
FBXO33	hsa-miR-181c-5p	80.1054	NM_203301
FBXO33	hsa-miR-181b-5p	80.1054	NM_203301

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Motifs and transcription factors (TFs) regulating FBXO33

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FBXO33	transfac_pro__M02913	SP140 (inferredBy_Orthology).
FBXO33	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
FBXO33	jaspar__MA0748.2	YY2 (directAnnotation).
FBXO33	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
FBXO33	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
FBXO33	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
FBXO33	cisbp__M00788	ZFY (inferredBy_Orthology).
FBXO33	transfac_pro__M00430	E2F1 (directAnnotation).
FBXO33	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
FBXO33	transfac_pro__M04893	TAF1 (directAnnotation).
FBXO33	transfac_pro__M01199	TRIM28 (directAnnotation).
FBXO33	hdpi__TP73	TP73 (directAnnotation).
FBXO33	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
FBXO33	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
FBXO33	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
FBXO33	hdpi__HIP2	UBE2K (directAnnotation).
FBXO33	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
FBXO33	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
FBXO33	metacluster_191.5	SPDEF (inferredBy_Orthology).
FBXO33	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
FBXO33	transfac_pro__M00938	E2F1 (directAnnotation).
FBXO33	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
FBXO33	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
FBXO33	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
FBXO33	hdpi__RARA	RARA (directAnnotation).
FBXO33	hdpi__ELF2	ELF2 (directAnnotation).
FBXO33	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
FBXO33	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
FBXO33	cisbp__M00968	MTF2 (directAnnotation).
FBXO33	transfac_pro__M02898	SMAD3 (directAnnotation).
FBXO33	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FBXO33	hdpi__HTATIP2	HTATIP2 (directAnnotation).
FBXO33	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
FBXO33	transfac_pro__M07310	SP5 (directAnnotation).
FBXO33	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
FBXO33	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
FBXO33	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
FBXO33	hdpi__ZNF304	ZNF304 (directAnnotation).
FBXO33	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
FBXO33	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FBXO33	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
FBXO33	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FBXO33	transfac_pro__M01861	ATF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."