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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM91A1

Summary for FAM91A1

Gene information	Gene symbol	FAM91A1
	Ensembl ID	ENSG00000176853
	Entrez ID	157769
	Gene name	family with sequence similarity 91 member A1
	Synonyms	FLJ23790
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FAM91A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.268632	3.02e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.33382	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.447158	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.351076	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.29234	0.00e+00

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Expression of FAM91A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM91A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM91A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM91A1	hsa-miR-6818-3p	86.3267	NM_001317917
FAM91A1	hsa-miR-4719	86.0259	NM_001317917
FAM91A1	hsa-miR-497-5p	85.8037	NM_001317917
FAM91A1	hsa-miR-424-5p	85.8037	NM_001317917
FAM91A1	hsa-miR-6838-5p	85.6398	NM_001317917
FAM91A1	hsa-miR-545-3p	85.4108	NM_001317917
FAM91A1	hsa-miR-12120	85.2409	NM_001317917
FAM91A1	hsa-miR-206	85.1398	NM_001317917
FAM91A1	hsa-miR-613	85.1398	NM_001317917
FAM91A1	hsa-miR-1-3p	85.1398	NM_001317917
FAM91A1	hsa-miR-1227-3p	84.72	NM_001317917
FAM91A1	hsa-miR-495-3p	84.635	NM_001317917
FAM91A1	hsa-miR-195-3p	84.6134	NM_001317917
FAM91A1	hsa-miR-16-2-3p	84.6134	NM_001317917
FAM91A1	hsa-miR-551b-5p	83.8343	NM_001317917
FAM91A1	hsa-miR-3143	83.5328	NM_001317917
FAM91A1	hsa-miR-6762-3p	82.9763	NM_001317917
FAM91A1	hsa-miR-4744	82.844	NM_001317917
FAM91A1	hsa-miR-4668-3p	82.8295	NM_001317917
FAM91A1	hsa-miR-4731-3p	82.6364	NM_001317917
FAM91A1	hsa-miR-3910	81.9473	NM_001317917
FAM91A1	hsa-miR-4761-5p	81.0835	NM_001317917
FAM91A1	hsa-miR-4282	80.949	NM_001317918

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Motifs and transcription factors (TFs) regulating FAM91A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM91A1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
FAM91A1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
FAM91A1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FAM91A1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
FAM91A1	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
FAM91A1	transfac_pro__M12686	ZBTB10 (directAnnotation).
FAM91A1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
FAM91A1	metacluster_143.14	ZNF320 (directAnnotation).
FAM91A1	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
FAM91A1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
FAM91A1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
FAM91A1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FAM91A1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
FAM91A1	transfac_pro__M04617	ZBTB7A (directAnnotation).
FAM91A1	transfac_pro__M01973	PLAG1 (directAnnotation).
FAM91A1	metacluster_151.2	ZNF23 (directAnnotation).
FAM91A1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
FAM91A1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
FAM91A1	cisbp__M01864	EGR1 (inferredBy_Orthology).
FAM91A1	tfdimers__MD00391	KLF4 (directAnnotation).
FAM91A1	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
FAM91A1	transfac_pro__M05479	ZNF580 (directAnnotation).
FAM91A1	tfdimers__MD00151	CHURC1 (directAnnotation).
FAM91A1	transfac_pro__M04817	ZBTB33 (directAnnotation).
FAM91A1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
FAM91A1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
FAM91A1	jaspar__MA1122.1	TFDP1 (directAnnotation).
FAM91A1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
FAM91A1	transfac_pro__M01253	CNOT3 (directAnnotation).
FAM91A1	metacluster_159.5	ZIC1; ZIC4; ZNF423 (directAnnotation). SP1 (inferredBy_Orthology).
FAM91A1	cisbp__M00968	MTF2 (directAnnotation).
FAM91A1	tfdimers__MD00038	TFAP2C (directAnnotation).
FAM91A1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
FAM91A1	transfac_pro__M01199	TRIM28 (directAnnotation).
FAM91A1	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
FAM91A1	metacluster_3.14	WT1; WT1 (directAnnotation).
FAM91A1	transfac_pro__M12697	ZNF142 (directAnnotation).
FAM91A1	metacluster_84.2	RARA (directAnnotation).
FAM91A1	transfac_pro__M07387	ZBTB7A (directAnnotation).
FAM91A1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
FAM91A1	transfac_pro__M04893	TAF1 (directAnnotation).
FAM91A1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
FAM91A1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
FAM91A1	kznf__EGR2_Barrera2016.3_PBM	EGR2 (directAnnotation).
FAM91A1	metacluster_23.8	GLIS1; GLIS1; GLIS1; GLIS2; GLIS2; GLIS2; GLIS2 (directAnnotation). GLIS2; GLIS3; ZXDA; ZXDB; ZXDC (inferredBy_Orthology).
FAM91A1	transfac_pro__M00986	CHURC1 (directAnnotation).
FAM91A1	metacluster_182.2	GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (directAnnotation). GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (inferredBy_Orthology).
FAM91A1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FAM91A1	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
FAM91A1	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."