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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM199X

Summary for FAM199X

Gene information	Gene symbol	FAM199X
	Ensembl ID	ENSG00000123575
	Entrez ID	139231
	Gene name	family with sequence similarity 199, X-linked
	Synonyms	CXorf39
	Gene type	protein_coding
	UniProtAcc	Q6PEV8

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Dataset with differentially expressed gene: FAM199X

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.575285	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.381089	4.24e-20

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Expression of FAM199X in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM199X

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM199X

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM199X	hsa-miR-570-3p	90.7449	NM_207318
FAM199X	hsa-miR-3123	90.695	NM_207318
FAM199X	hsa-miR-519e-5p	90.0326	NM_207318
FAM199X	hsa-miR-517-5p	89.8446	NM_207318
FAM199X	hsa-miR-1277-5p	89.8089	NM_207318
FAM199X	hsa-miR-4642	89.7987	NM_207318
FAM199X	hsa-miR-199b-3p	89.1302	NM_207318
FAM199X	hsa-miR-3129-5p	89.1302	NM_207318
FAM199X	hsa-miR-199a-3p	89.1302	NM_207318
FAM199X	hsa-miR-646	88.8458	NM_207318
FAM199X	hsa-miR-888-3p	88.7222	NM_207318
FAM199X	hsa-miR-5590-3p	88.4688	NM_207318
FAM199X	hsa-miR-12124	87.6708	NM_207318
FAM199X	hsa-miR-3662	87.5163	NM_207318
FAM199X	hsa-miR-20a-5p	87.4003	NM_207318
FAM199X	hsa-miR-1252-3p	87.2832	NM_207318
FAM199X	hsa-miR-7110-3p	87.214	NM_207318
FAM199X	hsa-miR-30c-2-3p	87.2103	NM_207318
FAM199X	hsa-miR-6788-5p	87.2103	NM_207318
FAM199X	hsa-miR-30c-1-3p	87.2103	NM_207318
FAM199X	hsa-miR-4659b-3p	87.055	NM_207318
FAM199X	hsa-miR-4659a-3p	87.055	NM_207318
FAM199X	hsa-miR-548at-5p	86.7913	NM_207318
FAM199X	hsa-miR-384	86.5061	NM_207318
FAM199X	hsa-miR-499b-5p	86.3782	NM_207318
FAM199X	hsa-miR-6766-3p	86.3751	NM_207318
FAM199X	hsa-miR-4782-3p	86.3751	NM_207318
FAM199X	hsa-miR-219a-5p	86.3751	NM_207318
FAM199X	hsa-miR-93-5p	86.3699	NM_207318
FAM199X	hsa-miR-17-5p	86.3699	NM_207318
FAM199X	hsa-miR-519d-3p	86.3699	NM_207318
FAM199X	hsa-miR-20b-5p	86.3699	NM_207318
FAM199X	hsa-miR-526b-3p	86.3699	NM_207318
FAM199X	hsa-miR-106b-5p	86.3699	NM_207318
FAM199X	hsa-miR-106a-5p	86.3699	NM_207318
FAM199X	hsa-miR-4731-3p	86.2437	NM_207318
FAM199X	hsa-miR-12113	85.9445	NM_207318
FAM199X	hsa-miR-4699-5p	85.3651	NM_207318
FAM199X	hsa-miR-155-5p	85.2053	NM_207318
FAM199X	hsa-miR-4539	85.0884	NM_207318
FAM199X	hsa-miR-1305	84.9431	NM_207318
FAM199X	hsa-miR-4794	84.8332	NM_207318
FAM199X	hsa-miR-1303	84.7394	NM_207318
FAM199X	hsa-miR-4469	84.5165	NM_207318
FAM199X	hsa-miR-4801	84.514	NM_207318
FAM199X	hsa-miR-126-5p	84.5006	NM_207318
FAM199X	hsa-miR-664a-5p	84.287	NM_207318
FAM199X	hsa-miR-9902	83.8911	NM_207318
FAM199X	hsa-miR-656-3p	83.5369	NM_207318
FAM199X	hsa-miR-30c-5p	83.4947	NM_207318

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Motifs and transcription factors (TFs) regulating FAM199X

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM199X	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
FAM199X	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
FAM199X	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
FAM199X	swissregulon__hs__ETV6	ETV6 (directAnnotation).
FAM199X	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
FAM199X	transfac_pro__M04826	EP300 (directAnnotation).
FAM199X	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
FAM199X	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
FAM199X	hdpi__ETV4	ETV4 (directAnnotation).
FAM199X	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
FAM199X	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
FAM199X	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
FAM199X	jaspar__MA0748.2	YY2 (directAnnotation).
FAM199X	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
FAM199X	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
FAM199X	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
FAM199X	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
FAM199X	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
FAM199X	hdpi__ELF2	ELF2 (directAnnotation).
FAM199X	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
FAM199X	swissregulon__hs__ELK1	ELK1 (directAnnotation).
FAM199X	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
FAM199X	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
FAM199X	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
FAM199X	metacluster_81.7	CREB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."