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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM168B

Summary for FAM168B

Gene information	Gene symbol	FAM168B
	Ensembl ID	ENSG00000152102
	Entrez ID	130074
	Gene name	family with sequence similarity 168 member B
	Synonyms	KIAA0280L\|MANI
	Gene type	protein_coding
	UniProtAcc	A1KXE4

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Dataset with differentially expressed gene: FAM168B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.439974	1.86e-28
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.315858	2.82e-26

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Expression of FAM168B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM168B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM168B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM168B	hsa-miR-520b-3p	86.8965	NM_001009993
FAM168B	hsa-miR-520a-3p	86.8965	NM_001009993
FAM168B	hsa-miR-520e-3p	86.8965	NM_001009993
FAM168B	hsa-miR-520c-3p	86.8965	NM_001009993
FAM168B	hsa-miR-373-3p	86.8965	NM_001009993
FAM168B	hsa-miR-520d-3p	86.8965	NM_001009993
FAM168B	hsa-miR-372-3p	86.8965	NM_001009993
FAM168B	hsa-miR-582-5p	85.833	NM_001009993
FAM168B	hsa-miR-5010-3p	85.7106	NM_001009993
FAM168B	hsa-miR-302d-5p	85.7074	NM_001009993
FAM168B	hsa-miR-892c-5p	85.2673	NM_001009993
FAM168B	hsa-miR-4662b	84.5558	NM_001009993
FAM168B	hsa-miR-5579-3p	84.5337	NM_001009993
FAM168B	hsa-miR-9718	84.4127	NM_001009993
FAM168B	hsa-miR-1226-3p	84.2626	NM_001009993
FAM168B	hsa-miR-12135	84.2127	NM_001009993
FAM168B	hsa-miR-548c-3p	83.7769	NM_001009993
FAM168B	hsa-miR-548x-5p	83.7428	NM_001009993
FAM168B	hsa-miR-548f-5p	83.7428	NM_001009993
FAM168B	hsa-miR-548aj-5p	83.7428	NM_001009993
FAM168B	hsa-miR-548g-5p	83.7428	NM_001009993
FAM168B	hsa-miR-607	83.3351	NM_001009993
FAM168B	hsa-miR-7-5p	83.1586	NM_001009993
FAM168B	hsa-miR-153-5p	83.0896	NM_001009993
FAM168B	hsa-miR-12136	82.9333	NM_001009993
FAM168B	hsa-miR-634	82.7392	NM_001009993
FAM168B	hsa-miR-3622b-5p	82.4907	NM_001009993
FAM168B	hsa-miR-655-3p	82.277	NM_001009993
FAM168B	hsa-miR-374c-5p	82.277	NM_001009993
FAM168B	hsa-miR-892b	82.0251	NM_001009993
FAM168B	hsa-miR-548aw	81.9022	NM_001009993
FAM168B	hsa-miR-628-5p	81.1471	NM_001009993
FAM168B	hsa-miR-4778-3p	80.8566	NM_001009993
FAM168B	hsa-miR-224-5p	80.8351	NM_001009993

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Motifs and transcription factors (TFs) regulating FAM168B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM168B	metacluster_135.11	NR2C2 (directAnnotation).
FAM168B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FAM168B	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FAM168B	metacluster_7.13	ZFX (directAnnotation).
FAM168B	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
FAM168B	cisbp__M00968	MTF2 (directAnnotation).
FAM168B	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
FAM168B	metacluster_160.20	JUND; PRDM15 (directAnnotation).
FAM168B	cisbp__M00341	PAX6 (directAnnotation).
FAM168B	metacluster_198.3	ZFP64 (directAnnotation).
FAM168B	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
FAM168B	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
FAM168B	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
FAM168B	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FAM168B	cisbp__M00788	ZFY (inferredBy_Orthology).
FAM168B	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
FAM168B	metacluster_175.1	ZNF283 (directAnnotation).
FAM168B	hdpi__ZNF304	ZNF304 (directAnnotation).
FAM168B	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
FAM168B	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
FAM168B	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
FAM168B	transfac_pro__M01199	TRIM28 (directAnnotation).
FAM168B	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
FAM168B	metacluster_151.2	ZNF23 (directAnnotation).
FAM168B	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FAM168B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
FAM168B	transfac_pro__M03806	ZBTB7C (directAnnotation).
FAM168B	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FAM168B	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
FAM168B	transfac_pro__M01253	CNOT3 (directAnnotation).
FAM168B	metacluster_134.7	FOXD2; FOXG1; FOXI1; FOXJ2; FOXJ2; FOXJ3; FOXJ3; FOXK1; FOXK1; FOXK2; FOXO4; FOXO6; FOXP2 (directAnnotation). FOXC1; FOXO1; FOXO6 (inferredBy_Orthology).
FAM168B	transfac_pro__M04817	ZBTB33 (directAnnotation).
FAM168B	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
FAM168B	transfac_pro__M05712	ZNF134 (directAnnotation).
FAM168B	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."