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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: F3

Summary for F3

Gene information	Gene symbol	F3
	Ensembl ID	ENSG00000117525
	Entrez ID	2152
	Gene name	coagulation factor III, tissue factor
	Synonyms	CD142\|TF
	Gene type	protein_coding
	UniProtAcc	P13726

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Dataset with differentially expressed gene: F3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.36175	2.67e-03
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.79759	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.275249	7.32e-08
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.271641	2.50e-05
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.542538	1.06e-22

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Expression of F3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to F3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating F3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
F3	hsa-miR-6827-3p	80.1698	NM_001993

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Motifs and transcription factors (TFs) regulating F3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
F3	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
F3	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
F3	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
F3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
F3	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
F3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
F3	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
F3	transfac_pro__M04866	HDAC2 (directAnnotation).
F3	jaspar__MA1122.1	TFDP1 (directAnnotation).
F3	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
F3	metacluster_135.11	NR2C2 (directAnnotation).
F3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
F3	tfdimers__MD00038	TFAP2C (directAnnotation).
F3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
F3	metacluster_7.13	ZFX (directAnnotation).
F3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
F3	cisbp__M00968	MTF2 (directAnnotation).
F3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
F3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
F3	cisbp__M00341	PAX6 (directAnnotation).
F3	metacluster_198.3	ZFP64 (directAnnotation).
F3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
F3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
F3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
F3	cisbp__M00788	ZFY (inferredBy_Orthology).
F3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
F3	metacluster_175.1	ZNF283 (directAnnotation).
F3	hdpi__ZNF304	ZNF304 (directAnnotation).
F3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
F3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
F3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
F3	transfac_pro__M01199	TRIM28 (directAnnotation).
F3	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
F3	metacluster_151.2	ZNF23 (directAnnotation).
F3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
F3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
F3	transfac_pro__M03806	ZBTB7C (directAnnotation).
F3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
F3	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
F3	metacluster_22.25	NFE2L2 (directAnnotation).
F3	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
F3	tfdimers__MD00339	HMGA1; HMGA2; TFAP2C (directAnnotation).
F3	metacluster_22.29	NFE2 (directAnnotation).
F3	metacluster_22.32	NFE2L2 (directAnnotation).
F3	metacluster_22.17	NFE2 (directAnnotation).
F3	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
F3	metacluster_22.37	BACH1 (directAnnotation).
F3	metacluster_22.11	NFE2 (directAnnotation).
F3	metacluster_22.16	BACH2 (directAnnotation).
F3	metacluster_22.39	NFE2L2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
F3	"2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE"	DB07207	small molecule
F3	"Coagulation factor VII human"	DB13150	biotech
F3	"Coagulation factor VIIa Recombinant Human"	DB00036	biotech
F3	"rNAPc2"	DB06552	biotech
F3	"Tisotumab vedotin"	DB16732	biotech
F3	"[2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA"	DB07247	small molecule
F3	"[5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid"	DB08232	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."