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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EPC1

Summary for EPC1

Gene information	Gene symbol	EPC1
	Ensembl ID	ENSG00000120616
	Entrez ID	80314
	Gene name	enhancer of polycomb homolog 1
	Synonyms	Epl1
	Gene type	protein_coding
	UniProtAcc	Q9H2F5

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Dataset with differentially expressed gene: EPC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.424679	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.256557	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.255265	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.732346	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	CD8+ T cells	0.255677	1.18e-43
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.653667	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.615784	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-1.10699	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.389559	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-1.05269	0.00e+00
GSE152469	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	NA	Malignant cells	0.309994	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.364623	0.00e+00

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Expression of EPC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EPC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EPC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EPC1	hsa-miR-4533	87.8739	NM_001282391
EPC1	hsa-miR-516b-5p	87.1637	NM_001272004
EPC1	hsa-miR-505-3p	87.0529	NM_001272004
EPC1	hsa-miR-330-3p	86.8108	NM_001272004
EPC1	hsa-miR-6871-3p	86.3902	NM_001272004
EPC1	hsa-miR-1244	86.1112	NM_001272004
EPC1	hsa-miR-15a-5p	85.4923	NM_001272004
EPC1	hsa-miR-16-5p	85.4923	NM_001272004
EPC1	hsa-miR-195-5p	85.4923	NM_001272004
EPC1	hsa-miR-548f-3p	85.4292	NM_001272004
EPC1	hsa-miR-548az-3p	85.4292	NM_001272004
EPC1	hsa-miR-548e-3p	85.4292	NM_001272004
EPC1	hsa-miR-548ar-3p	85.4292	NM_001272004
EPC1	hsa-miR-548bc	85.4292	NM_001272004
EPC1	hsa-miR-548a-3p	85.4292	NM_001272004
EPC1	hsa-miR-532-5p	85.113	NM_001272004
EPC1	hsa-miR-577	84.982	NM_001282391
EPC1	hsa-miR-3682-3p	84.6785	NM_001272004
EPC1	hsa-miR-4531	84.4061	NM_001272004
EPC1	hsa-miR-503-3p	84.162	NM_001282391
EPC1	hsa-miR-365b-3p	84.0161	NM_001282391
EPC1	hsa-miR-365a-3p	84.0161	NM_001282391
EPC1	hsa-miR-15b-5p	83.2942	NM_001272004
EPC1	hsa-miR-424-5p	83.2942	NM_001272004
EPC1	hsa-miR-6838-5p	83.2942	NM_001272004
EPC1	hsa-miR-497-5p	83.2942	NM_001272004
EPC1	hsa-miR-512-3p	83.0801	NM_001272004
EPC1	hsa-miR-5010-3p	83.0773	NM_001282391
EPC1	hsa-miR-203a-5p	83.0742	NM_001272004
EPC1	hsa-miR-3686	82.2295	NM_001282391
EPC1	hsa-miR-7112-3p	81.9512	NM_001282391
EPC1	hsa-miR-22-3p	81.5349	NM_001272004
EPC1	hsa-miR-3190-3p	81.2456	NM_001282391
EPC1	hsa-miR-381-3p	80.5865	NM_001282391
EPC1	hsa-miR-300	80.5865	NM_001282391
EPC1	hsa-miR-624-5p	80.5182	NM_001272004
EPC1	hsa-miR-873-5p	80.4542	NM_001272004
EPC1	hsa-miR-5197-3p	80.073	NM_001272004

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Motifs and transcription factors (TFs) regulating EPC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EPC1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
EPC1	transfac_pro__M05768	ZNF544 (directAnnotation).
EPC1	transfac_pro__M02843	BBX (inferredBy_Orthology).
EPC1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
EPC1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
EPC1	transfac_pro__M07397	ZNF148 (directAnnotation).
EPC1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
EPC1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
EPC1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
EPC1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
EPC1	metacluster_7.13	ZFX (directAnnotation).
EPC1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
EPC1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
EPC1	transfac_pro__M01175	ZBTB7B (directAnnotation).
EPC1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
EPC1	tfdimers__MD00151	CHURC1 (directAnnotation).
EPC1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
EPC1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
EPC1	transfac_pro__M01303	SP1 (directAnnotation).
EPC1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
EPC1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
EPC1	transfac_pro__M02090	E2F4 (directAnnotation).
EPC1	transfac_pro__M01714	KLF15 (directAnnotation).
EPC1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
EPC1	jaspar__MA1122.1	TFDP1 (directAnnotation).
EPC1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
EPC1	transfac_pro__M02089	E2F3 (directAnnotation).
EPC1	metacluster_3.14	WT1; WT1 (directAnnotation).
EPC1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
EPC1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
EPC1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
EPC1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
EPC1	cisbp__M07938	E2F1 (directAnnotation).
EPC1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
EPC1	transfac_pro__M07436	WT1 (directAnnotation).
EPC1	transfac_pro__M02281	SP1 (directAnnotation).
EPC1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
EPC1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
EPC1	transfac_pro__M02898	SMAD3 (directAnnotation).
EPC1	transfac_public__M00491	PATZ1 (directAnnotation).
EPC1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
EPC1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
EPC1	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
EPC1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
EPC1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
EPC1	transfac_pro__M05905	ZNF649 (directAnnotation).
EPC1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
EPC1	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
EPC1	hocomoco__SOX9_HUMAN.H11MO.1.B	SOX9 (directAnnotation).
EPC1	metacluster_168.3	NR4A1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."