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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ELAVL1

Summary for ELAVL1

Gene information	Gene symbol	ELAVL1
	Ensembl ID	ENSG00000066044
	Entrez ID	1994
	Gene name	ELAV like RNA binding protein 1
	Synonyms	Hua\|HUR\|MelG
	Gene type	protein_coding
	UniProtAcc	Q15717

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Dataset with differentially expressed gene: ELAVL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.325135	4.46e-19
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.288347	6.60e-09
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.410296	1.61e-24
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.354937	2.67e-14
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.479627	0.00e+00

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Expression of ELAVL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ELAVL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ELAVL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ELAVL1	hsa-miR-6837-3p	91.2235	NM_001419
ELAVL1	hsa-miR-518c-5p	90.9332	NM_001419
ELAVL1	hsa-miR-4769-5p	90.6692	NM_001419
ELAVL1	hsa-miR-493-5p	90.6047	NM_001419
ELAVL1	hsa-miR-3148	90.5203	NM_001419
ELAVL1	hsa-miR-3662	90.3807	NM_001419
ELAVL1	hsa-miR-548au-3p	90.3167	NM_001419
ELAVL1	hsa-miR-3121-3p	89.8272	NM_001419
ELAVL1	hsa-miR-4666a-5p	89.059	NM_001419
ELAVL1	hsa-miR-4698	88.9968	NM_001419
ELAVL1	hsa-miR-556-3p	88.7912	NM_001419
ELAVL1	hsa-miR-3159	88.6574	NM_001419
ELAVL1	hsa-miR-330-3p	88.409	NM_001419
ELAVL1	hsa-let-7a-2-3p	88.2118	NM_001419
ELAVL1	hsa-let-7g-3p	88.2118	NM_001419
ELAVL1	hsa-miR-4520-2-3p	87.574	NM_001419
ELAVL1	hsa-miR-3714	87.4133	NM_001419
ELAVL1	hsa-miR-10527-5p	87.3592	NM_001419
ELAVL1	hsa-miR-31-5p	87.3292	NM_001419
ELAVL1	hsa-miR-3163	87.196	NM_001419
ELAVL1	hsa-miR-449c-5p	86.8344	NM_001419
ELAVL1	hsa-miR-2682-5p	86.8344	NM_001419
ELAVL1	hsa-miR-34b-5p	86.8344	NM_001419
ELAVL1	hsa-miR-6778-5p	86.6889	NM_001419
ELAVL1	hsa-miR-6128	86.653	NM_001419
ELAVL1	hsa-miR-133b	86.3688	NM_001419
ELAVL1	hsa-miR-133a-3p	86.3688	NM_001419
ELAVL1	hsa-miR-6835-3p	86.1295	NM_001419
ELAVL1	hsa-miR-10398-5p	85.8746	NM_001419
ELAVL1	hsa-miR-6731-3p	85.1286	NM_001419
ELAVL1	hsa-miR-4728-5p	85.0337	NM_001419
ELAVL1	hsa-miR-6785-5p	85.0337	NM_001419
ELAVL1	hsa-miR-33a-3p	84.8953	NM_001419
ELAVL1	hsa-miR-513b-5p	84.7219	NM_001419
ELAVL1	hsa-miR-149-3p	82.6808	NM_001419
ELAVL1	hsa-miR-6883-5p	82.6808	NM_001419
ELAVL1	hsa-miR-5688	82.3828	NM_001419
ELAVL1	hsa-miR-1468-3p	82.2733	NM_001419
ELAVL1	hsa-miR-3138	82.0676	NM_001419
ELAVL1	hsa-miR-5696	81.9614	NM_001419
ELAVL1	hsa-miR-3646	81.857	NM_001419
ELAVL1	hsa-miR-1233-5p	81.7844	NM_001419
ELAVL1	hsa-miR-4520-3p	81.7475	NM_001419
ELAVL1	hsa-miR-4729	81.3996	NM_001419
ELAVL1	hsa-miR-514a-5p	81.2786	NM_001419
ELAVL1	hsa-miR-3658	81.069	NM_001419
ELAVL1	hsa-miR-522-3p	80.539	NM_001419
ELAVL1	hsa-miR-224-3p	80.539	NM_001419
ELAVL1	hsa-miR-6794-3p	80.4331	NM_001419
ELAVL1	hsa-miR-4704-5p	80.4176	NM_001419

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Motifs and transcription factors (TFs) regulating ELAVL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ELAVL1	metacluster_7.13	ZFX (directAnnotation).
ELAVL1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
ELAVL1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ELAVL1	metacluster_151.2	ZNF23 (directAnnotation).
ELAVL1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ELAVL1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
ELAVL1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ELAVL1	metacluster_182.10	ZFX (directAnnotation).
ELAVL1	hdpi__ETV4	ETV4 (directAnnotation).
ELAVL1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ELAVL1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ELAVL1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
ELAVL1	transfac_pro__M04826	EP300 (directAnnotation).
ELAVL1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ELAVL1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
ELAVL1	metacluster_81.7	CREB1 (directAnnotation).
ELAVL1	hdpi__ELF2	ELF2 (directAnnotation).
ELAVL1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
ELAVL1	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
ELAVL1	dbtfbs__ZNF121_HEK293_ENCSR224QDY_merged_N3	ZNF121 (directAnnotation).
ELAVL1	jaspar__MA0502.2	NFYB (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."