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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: EGLN1

Summary for EGLN1

Gene information	Gene symbol	EGLN1
	Ensembl ID	ENSG00000135766
	Entrez ID	54583
	Gene name	egl-9 family hypoxia inducible factor 1
	Synonyms	C1orf12\|HIFPH2\|PHD2\|SM-20\|ZMYND6
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: EGLN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.266746	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.293933	2.84e-15
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.423782	1.81e-31
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.06517	0.00e+00

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Expression of EGLN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EGLN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EGLN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EGLN1	hsa-miR-24-2-5p	82.3295	NM_022051
EGLN1	hsa-miR-4716-5p	82.2899	NM_022051
EGLN1	hsa-miR-633	82.2642	NM_022051
EGLN1	hsa-miR-12136	82.2277	NM_022051
EGLN1	hsa-miR-4301	81.8599	NM_022051
EGLN1	hsa-miR-3646	81.7594	NM_022051
EGLN1	hsa-miR-4799-3p	81.5976	NM_022051
EGLN1	hsa-miR-4720-5p	81.5976	NM_022051
EGLN1	hsa-miR-5588-5p	81.5976	NM_022051
EGLN1	hsa-miR-4307	81.125	NM_022051
EGLN1	hsa-miR-6832-5p	80.8279	NM_022051
EGLN1	hsa-miR-8084	80.7795	NM_022051
EGLN1	hsa-miR-6868-5p	80.728	NM_022051
EGLN1	hsa-miR-3182	80.6071	NM_022051
EGLN1	hsa-miR-576-3p	80.3879	NM_022051
EGLN1	hsa-miR-129-2-3p	80.3761	NM_022051
EGLN1	hsa-miR-129-1-3p	80.3761	NM_022051

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Motifs and transcription factors (TFs) regulating EGLN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EGLN1	dbtfbs__ZNF121_HEK293_ENCSR224QDY_merged_N3	ZNF121 (directAnnotation).
EGLN1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
EGLN1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
EGLN1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
EGLN1	metacluster_7.13	ZFX (directAnnotation).
EGLN1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
EGLN1	cisbp__M00968	MTF2 (directAnnotation).
EGLN1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
EGLN1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
EGLN1	metacluster_198.3	ZFP64 (directAnnotation).
EGLN1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
EGLN1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
EGLN1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
EGLN1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
EGLN1	cisbp__M00788	ZFY (inferredBy_Orthology).
EGLN1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
EGLN1	metacluster_175.1	ZNF283 (directAnnotation).
EGLN1	hdpi__ZNF304	ZNF304 (directAnnotation).
EGLN1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
EGLN1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
EGLN1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
EGLN1	transfac_pro__M01199	TRIM28 (directAnnotation).
EGLN1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
EGLN1	metacluster_151.2	ZNF23 (directAnnotation).
EGLN1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
EGLN1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
EGLN1	transfac_pro__M03806	ZBTB7C (directAnnotation).
EGLN1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
EGLN1	jaspar__MA1954.1	FOXO1 (directAnnotation).
EGLN1	jaspar__MA1946.1	FOXI1 (directAnnotation).
EGLN1	jaspar__MA1955.1	FOXO1 (directAnnotation).
EGLN1	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
EGLN1	transfac_pro__M04886	ETS1 (directAnnotation).
EGLN1	transfac_pro__M04913	ZBTB7A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
EGLN1	"Ascorbic acid"	DB00126	small molecule
EGLN1	"Daprodustat"	DB11682	small molecule
EGLN1	"Ferrous ascorbate"	DB14490	small molecule
EGLN1	"Ferrous fumarate"	DB14491	small molecule
EGLN1	"Ferrous gluconate"	DB14488	small molecule
EGLN1	"Ferrous glycine sulfate"	DB14501	small molecule
EGLN1	"Ferrous succinate"	DB14489	small molecule
EGLN1	"FG-2216"	DB08687	small molecule
EGLN1	"Iron"	DB01592	small molecule
EGLN1	"N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE"	DB07112	small molecule
EGLN1	"Roxadustat"	DB04847	small molecule
EGLN1	"Vadadustat"	DB12255	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."