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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EDIL3

Summary for EDIL3

Gene information	Gene symbol	EDIL3
	Ensembl ID	ENSG00000164176
	Entrez ID	10085
	Gene name	EGF like repeats and discoidin domains 3
	Synonyms	DEL1
	Gene type	protein_coding
	UniProtAcc	O43854

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Dataset with differentially expressed gene: EDIL3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.42202	8.01e-11
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.62069	0.00e+00

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Expression of EDIL3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EDIL3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EDIL3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EDIL3	hsa-miR-4496	91.6652	NM_001278642
EDIL3	hsa-miR-103a-3p	91.4542	NM_001278642
EDIL3	hsa-miR-107	91.4542	NM_001278642
EDIL3	hsa-miR-361-5p	91.4047	NM_005711
EDIL3	hsa-miR-3662	91.2766	NM_005711
EDIL3	hsa-miR-506-5p	91.2291	NM_005711
EDIL3	hsa-miR-190a-3p	91.1412	NM_001278642
EDIL3	hsa-miR-137-3p	90.8765	NM_001278642
EDIL3	hsa-miR-590-3p	90.0834	NM_005711
EDIL3	hsa-miR-5692a	89.9591	NM_005711
EDIL3	hsa-miR-496	89.8052	NM_005711
EDIL3	hsa-miR-425-5p	89.7136	NM_001278642
EDIL3	hsa-miR-548p	89.5752	NM_001278642
EDIL3	hsa-miR-24-1-5p	89.5645	NM_001278642
EDIL3	hsa-miR-24-2-5p	89.5645	NM_001278642
EDIL3	hsa-miR-520d-5p	89.5376	NM_005711
EDIL3	hsa-miR-524-5p	89.5376	NM_005711
EDIL3	hsa-miR-651-3p	89.4091	NM_001278642
EDIL3	hsa-miR-381-3p	89.0498	NM_005711
EDIL3	hsa-miR-300	89.0498	NM_005711
EDIL3	hsa-miR-376c-3p	88.1858	NM_005711
EDIL3	hsa-miR-466	87.7975	NM_001278642
EDIL3	hsa-miR-3646	87.1461	NM_005711
EDIL3	hsa-miR-338-5p	86.8523	NM_005711
EDIL3	hsa-miR-1252-3p	86.6581	NM_001278642
EDIL3	hsa-miR-340-5p	86.4489	NM_005711
EDIL3	hsa-miR-4753-3p	86.2325	NM_001278642
EDIL3	hsa-miR-3685	86.0839	NM_001278642
EDIL3	hsa-miR-2115-3p	85.9417	NM_005711
EDIL3	hsa-miR-4760-3p	85.9369	NM_005711
EDIL3	hsa-miR-6505-5p	85.5814	NM_005711
EDIL3	hsa-miR-155-3p	84.9567	NM_001278642
EDIL3	hsa-miR-6809-3p	84.7531	NM_001278642
EDIL3	hsa-miR-607	84.4885	NM_001278642
EDIL3	hsa-miR-1277-5p	84.3849	NM_005711
EDIL3	hsa-miR-5680	83.4024	NM_005711
EDIL3	hsa-miR-4712-3p	83.1854	NM_005711
EDIL3	hsa-miR-3935	83.0141	NM_005711
EDIL3	hsa-miR-4699-5p	83.0109	NM_005711
EDIL3	hsa-miR-3941	82.946	NM_001278642
EDIL3	hsa-miR-548d-3p	82.6668	NM_005711
EDIL3	hsa-miR-216b-3p	82.3997	NM_005711
EDIL3	hsa-miR-4645-3p	82.1029	NM_005711
EDIL3	hsa-miR-6739-3p	81.8993	NM_005711
EDIL3	hsa-miR-1270	81.5038	NM_001278642
EDIL3	hsa-miR-620	81.5038	NM_001278642
EDIL3	hsa-miR-3612	81.4424	NM_001278642
EDIL3	hsa-miR-650	81.4424	NM_001278642
EDIL3	hsa-miR-513a-5p	81.2057	NM_005711
EDIL3	hsa-miR-4311	81.1388	NM_001278642

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Motifs and transcription factors (TFs) regulating EDIL3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EDIL3	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
EDIL3	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
EDIL3	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
EDIL3	transfac_pro__M04950	EGR1 (directAnnotation).
EDIL3	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
EDIL3	transfac_pro__M04826	EP300 (directAnnotation).
EDIL3	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
EDIL3	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
EDIL3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
EDIL3	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
EDIL3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
EDIL3	transfac_pro__M00652	NRF1 (directAnnotation).
EDIL3	hdpi__ETV4	ETV4 (directAnnotation).
EDIL3	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
EDIL3	transfac_pro__M04866	HDAC2 (directAnnotation).
EDIL3	jaspar__MA1122.1	TFDP1 (directAnnotation).
EDIL3	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
EDIL3	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
EDIL3	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
EDIL3	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
EDIL3	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
EDIL3	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
EDIL3	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
EDIL3	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
EDIL3	transfac_pro__M04617	ZBTB7A (directAnnotation).
EDIL3	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
EDIL3	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
EDIL3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
EDIL3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
EDIL3	transfac_pro__M07387	ZBTB7A (directAnnotation).
EDIL3	transfac_pro__M07436	WT1 (directAnnotation).
EDIL3	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
EDIL3	transfac_pro__M00716	ZBTB14 (directAnnotation).
EDIL3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
EDIL3	hdpi__HIP2	UBE2K (directAnnotation).
EDIL3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
EDIL3	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
EDIL3	transfac_pro__M04893	TAF1 (directAnnotation).
EDIL3	transfac_pro__M03876	ZBTB33 (directAnnotation).
EDIL3	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
EDIL3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
EDIL3	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
EDIL3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
EDIL3	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."